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Carcinoma of the Stomach

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Abstract

Carcinoma of the stomach was the leading cause of cancer death at the beginning of the century, but presently in the United States, ranks sixth among cancer deaths and third among malignant tumors of the gastrointestinal tract. The yearly death toll is approximately 14,000 (i. e., half the mortality of 1948).1 The incidence of the disease has declined steadily over the last decades as reflected by the change in the age-adjusted death rates. The death rate in the United States was 10 men and 5 women per 100,000 population in 1965 as opposed to 6.8 and 3.2 in 1976.2 For 1984, however, the comparable figures are higher as 8 per 100,000 men and 4 per 100,000 women died of gastric cancer.3 The estimated number of new cases has also increased slightly, and was reported as 23,000 in 1979, 23,900 in 1981, 24,000 in 1982, and 24,600 in 1987.3

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References

  1. American Cancer Society: Cancer Facts and Figures, 1983. New York: American Cancer Society, 1983.

    Google Scholar 

  2. Segi M: Age-adjusted death rates for cancer for selected sites (A-classification) in 40 countries in 1976, Nagoya: Segi Institute of Cancer Epidemiology, 1981.

    Google Scholar 

  3. Silverberg E: Cancer statistics 1987. CA 1987; 37: 2–19.

    Google Scholar 

  4. Møller Jensen O: Trends in the incidence of stomach cancer in the five Nordic countries; in Magnus K (ed): Trends in Cancer Incidence. Washington: Hemisphere Publishing, 1982: 127–142.

    Google Scholar 

  5. Waterhouse J, Muir C, Shanmugaratnam K, et al (eds): Cancer Incidence in Five Continents. Vol. IV (IARC Scientific Publications No. 42). Lyon: International Agency for Research on Cancer, 1982.

    Google Scholar 

  6. Naraynsingh V: Gastric carcinoma in the West Indies: a Trinidad study. Cancer 1985; 56: 2117–2119.

    PubMed  CAS  Google Scholar 

  7. Kawai K, Kizu M, Miyaoka T: Epidemiology and pathogenesis of gastric cancer. Front Gastrointest Res 1980; 6: 71–86.

    PubMed  CAS  Google Scholar 

  8. Faivre J, Justrabo E, Hillon P, et al: Gastric carcinoma in Cote d’Or (France). A population-based study. Gastroenterology 1985; 88: 1874–1979.

    PubMed  CAS  Google Scholar 

  9. Young JL, Percy CL, Asire AJ: Surveillance, Epidemiology and End Results. Incidence and Mortality Data, 1973–1977. National Cancer Institute Monograph No. 57. Washington DC: U.S. Government Printing Office, 1981.

    Google Scholar 

  10. Blass RS, Miller TA, Copeland EM: Carcinoma of the stomach in the young adult. Surg Gynecol Obstet 1980; 150: 883–886.

    Google Scholar 

  11. Hansen RM, Hanson GA: Gastric carcinoma in young people. Am J Gastroenterol 1980; 1974: 497–503.

    Google Scholar 

  12. Chen P-C, Wu C-S, Chang-Chien C-S, et al: Gastric carcinoma in young adults. J Formo- san Med Assoc 1981; 80: 625–629.

    CAS  Google Scholar 

  13. Mahour GH, Isaacs H, Chang L: Primary malignant tumors of the stomach in children. J Pediatr Surg 1980; 15: 603–608.

    PubMed  CAS  Google Scholar 

  14. Correa P: Clinical implications of recent developments in gastric cancer pathology and epidemiology. Semin Oncol 1985; 12: 2–10.

    PubMed  CAS  Google Scholar 

  15. Haenszel WM: Cancer mortality and incidence among the foreign born in the United States. J Natl Cancer Inst 1961; 26: 37–132.

    PubMed  CAS  Google Scholar 

  16. Munoz N, Connelly R: Time trends of intestinal and diffuse type of gastric cancer in the United States. Int J Cancer 1971; 8: 158–164.

    PubMed  CAS  Google Scholar 

  17. Grabiec J, Owen D: Carcinoma of the stomach in young persons. Cancer 1985;56:388– 396.

    Google Scholar 

  18. Mecklin J-P, Nordling S, Saario I: Carcinoma of the stomach and its heredity in young patients. Scand J Gastroenterol 1988; 23: 307–311.

    PubMed  CAS  Google Scholar 

  19. Woolf CM, Gardner EJ: Carcinoma of gastrointestinal tract in Utah family. J Hered 1950; 41: 273–276.

    PubMed  CAS  Google Scholar 

  20. Jackson CE, Brownlee RW, Schuman BM, et al: Observations on gastric cancer in San Marino. Cancer 1980; 45: 599–602.

    PubMed  CAS  Google Scholar 

  21. Cruze K, Clarke JS, El Farra S: Familial aspects of gastric adenocarcinoma. Am J Dig Dis 1961; 6: 7–10.

    PubMed  CAS  Google Scholar 

  22. Xu G-W: Gastric cancer in China: A review. J R Soc Med 1981; 74: 210–212.

    PubMed  CAS  Google Scholar 

  23. Lehtola J: Familial behaviour of gastric car-cinoma. Ann Clin Res 1981; 13: 144–148.

    PubMed  CAS  Google Scholar 

  24. Coffey RJ, Knight CD, van Heerden JA, et al: Gastric adenocarcinoma complicating Gardner’s syndrome in a North American woman. Gastroenterology 1985; 88: 1263–1266.

    PubMed  Google Scholar 

  25. Halbert RE: Peutz-Jeghers syndrome with metastasizing gastric adenocarcinoma. Re-port of a case. Arch Pathol Lab Med 1982; 106: 517–520.

    PubMed  CAS  Google Scholar 

  26. Correa P, Sasano N, Stemmermann GN, Hanszel W: Pathology of gastric carcinoma in Japanese populations: Comparison between Miyagi prefecture, Japan, and Hawaii. J Natl Cancer Inst 1973; 51: 1449–1459.

    PubMed  CAS  Google Scholar 

  27. Ihamoki T, Sipponen P: Familial characteristics of gastric carcinoma. Ann Clin Res 1981; 13: 149–150.

    Google Scholar 

  28. Varis K: Family behaviour of chronic gastri-tis. Ann Clin Res 1981; 13: 125–129.

    Google Scholar 

  29. Furukawa H, Iwanaga T, Koyama H, et al: Effect of sex hormones on the experimental induction of cancer in rat stomach-a preliminary study. Digestion 1982; 23: 151–155.

    PubMed  CAS  Google Scholar 

  30. Cwern M, Garcia RL, Davidson MI, et al: Simultaneous occurrence of gastric carcinoma in identical twins. Am J Gastroenterol 1981; 75: 41–47.

    PubMed  CAS  Google Scholar 

  31. Ellis A, Hughes S, McConnell RB: Gastric neoplasms and pepsinogen phenotypes. Br J Cancer 1982; 46: 289–290.

    PubMed  CAS  Google Scholar 

  32. Sugimura T, Kawachi T: Experimental stomach cancer. Methods Cancer Res 1973; 7: 245–308.

    CAS  Google Scholar 

  33. Wieman TJ, Max MH, Voyles CR, et al: Diversion of duodenal contents. Its effect on the production of experimental gastric cancer. Arch Surg 1980; 115: 959–961.

    PubMed  CAS  Google Scholar 

  34. Morgan RW, Ward JM, Hartmen PE: Aroclor 1254-induced intestinal metaplasia and adenocarcinoma in the glandular stomach of F344 rats. Cancer Res 1981; 41: 5052–5059.

    PubMed  CAS  Google Scholar 

  35. Tahara E, Shimamoto F, Toniyama K, et al: Enhanced effect of gastrin on rat stomach carcinogenesis induced by N-methyl-N-nitro- N-nitrosoguanidine. Cancer Res 1982; 42: 1781–1787.

    PubMed  CAS  Google Scholar 

  36. Takahashi M, Shirai T, Fukushima S, etal: Ulcer formation and associated tumor pro-duction in multiple sites within the stomach and duodenum of rats treated with N-methyl- N-nitro-N-nitrosoguanidine. J Natl Cancer Inst 1981; 67: 473–477.

    PubMed  CAS  Google Scholar 

  37. Tsiftsis D, Jass JR, Filipe MI, et al: Altered patterns of mucin secretion in precancerous lesions induced in the glandular part of the rat stomach by the carcinogen N-methyl-N- nitro-N-nitrosoguanidine. Invest Cell Pathol 1980; 3: 399–408.

    PubMed  CAS  Google Scholar 

  38. Deveney CW, Freeman H, Way LW: Experimental gastric carcinogenesis in the rat. Effects of hypergastrinemia and acid secre-tion. Am J Surg 1980; 139: 49–54.

    PubMed  CAS  Google Scholar 

  39. Kuratsuhe M, Yoshimura T, Matsuzaka J, et al: Epidemiologic study on yosho, a poisoning caused by ingestion of rice oil contaminated with a commercial brand of polychlorinated biphenyls. Environ Health Perspect 1972; 1: 119–128.

    Google Scholar 

  40. Armijo R, Coulson AH: Epidemiology of stomach cancer in Chile-the role of nitrogen fertilizers. Int J Epidemiol 1975; 4: 301–309.

    Google Scholar 

  41. Armijo R, Orellana M, Medina E, et al: Epidemiology of gastric cancer in Chile: I-case control study. Int J Epidemiol 1981; 10: 53–62.

    PubMed  CAS  Google Scholar 

  42. Correa P, Cuello C, Gordillo G, et al: The gastric microenvironment in populations at high risk to stomach cancer. Natl Cancer Inst Monogr 1979; 53: 167–170.

    PubMed  Google Scholar 

  43. Drasar BS, Hill MJ: Metabolism of nitrogen compounds, in Human Intestinal Flora. London: Academic Press, 1974: 72–102.

    Google Scholar 

  44. Reed PI, Haines K, Smith PLR, etal: Gastric juice N-nitrosamines in health and gastro- duodenal disease. Lancet 1981; Sept 12: 550–553.

    Google Scholar 

  45. Schmahl D, Habs M: Carcinogenicity of N- nitroso compounds. Oncology 1980;37:237– 242.

    Google Scholar 

  46. Stockbrugger RW, Cotton PB, Eugenider N, et al: Intragastric nitrites, nitrosamines, and bacterial overgrowth during cimetadine treatment. Gut 1982; 23: 1048–1054.

    PubMed  CAS  Google Scholar 

  47. Brimblecombe RW, Duncan WAM, Duran GJ, et al: Characterization and development of cimetadine as a histamine H2-receptor antagonist. Gastroenterology 1978; 74: 339–347.

    PubMed  CAS  Google Scholar 

  48. Crean GP, Leslie GB, Roe FJC: Cimetadine and gastric cancer: Negative studies in dogs. Lancet 1979; Oct 13: 797–798.

    Google Scholar 

  49. Reed PI, Haines K, Walters CL, etal: Cimeta¬dine, nitrosation and carcinogenicity. Lancet 1981; Dec 5: 1281–1282.

    Google Scholar 

  50. Enterline PE: Mortality rates among coal miners. Am J Pub Health 1964; 54: 758–768.

    PubMed  CAS  Google Scholar 

  51. Ames R: Gastric cancer in coal miners: Some hypotheses for investigation. J Soc Occup Med 1982; 32: 73–81.

    PubMed  CAS  Google Scholar 

  52. Weinberg GB, Kuller LH, Stehr PA: A case- control study of stomach cancer in a coal mining region of Pennsylvania. Cancer 1985; 56: 703–713.

    PubMed  CAS  Google Scholar 

  53. Meyer MB, Luk GD, Sotelo JM, et al: Hypo-thesis: The role of the lung in stomach carcinogenesis. Am Rev Respir Dis 1980; 121: 887–892.

    PubMed  CAS  Google Scholar 

  54. Berg J: Diet, in Fraumeni J (ed): Persons at High Risk of Cancer. New York: Academic Press, 1975: 201–224.

    Google Scholar 

  55. Correa P, Cuello C, Fajardo LF, et al: Diet and gastric cancer: Nutrition survey in a high risk area. J Natl Cancer Inst 1983; 70: 673–678.

    PubMed  CAS  Google Scholar 

  56. Armijo R, Gonzales A, Orellana M, et al: Epidemiology of gastric cancer in Chile: II- nitrate exposures and stomach cancer frequency. Int J Epidemiol 1981; 10: 57–62.

    PubMed  CAS  Google Scholar 

  57. Joossens JV, Geboers J: Nutrition and gastric cancer. Nutr Cancer 1981; 2: 250–261.

    PubMed  CAS  Google Scholar 

  58. Whelton PK, Goldblatt P: An investigation of the relationship between stomach cancer and cerebrovascular disease. Am J Epidemiol 1982; 115: 418–427.

    PubMed  CAS  Google Scholar 

  59. Zemla B: A possible association between quality of drinking water and stomach cancer incidence among native and immigrant populations of a selected industrial city. Neoplasma 1980; 27: 55–61.

    PubMed  CAS  Google Scholar 

  60. Hoey J, Montvernay C, Lambert R: Wine and tobacco: Risk factors for gastric cancer in France. Am J Epidemiol 1981; 113: 668–673.

    PubMed  CAS  Google Scholar 

  61. Botha JL, Irwig LM, Stebel PM: Excess mor-tality from stomach cancer, lung cancer, and asbestosis and/or mesothelioma in crocidolite mining districts in South Africa. Am J Epidemiol 1986; 123: 30–40.

    PubMed  CAS  Google Scholar 

  62. Morgan RW, Foliart DE, Wong O: Asbestos and gastrointestinal cancer. West J Med 1985; 143: 60–65.

    PubMed  CAS  Google Scholar 

  63. Kraus AS, Levin ML, Gerhardt PR: A study of occupational associations with gastric cancer. Am J Pub Health 1957; 47: 961–970.

    PubMed  CAS  Google Scholar 

  64. Järvholm B, Lillienberg L, Axelson O: The risk of digestive cancer in workers using synthetic abrasive products. J Occup Med 1982; 24: 562–563.

    PubMed  Google Scholar 

  65. LeShan L: You Can Fight for Your Life: Emotional Factors in the Causation of Cancer. New York: M Evans, 1977.

    Google Scholar 

  66. Lehrer S: Life change and gastric cancer. Psychosom Med 1980; 42: 499–502.

    PubMed  CAS  Google Scholar 

  67. Kohn HI, Fry RJM: Radiation carcinogenesis. N Engl J Med 1984; 310: 504–510.

    PubMed  CAS  Google Scholar 

  68. Wakabayashi T, Kato H, Ikeda T, et al: Studies of the mortality of A-bomb survivors. Report 7. Part III. Incidence of cancer in 1959–1978, based on the Tumor Registry, Nagasaki. Radiat Res 1983; 93: 112–146.

    PubMed  CAS  Google Scholar 

  69. Scott RK, Holman WP, Sinckh ES: X-ray irradiation and conservative surgery with chronic duodenal ulcer. J Fac Radiol (London) 1953; 5: 42–47.

    Google Scholar 

  70. Brown WMC, Doll R: Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis. Br Med J 1965; 2: 1327–1332.

    PubMed  CAS  Google Scholar 

  71. Sellin J, Levin B, Reckard C, et al: Gastric adenocarcinoma following gastric lymphoma. Cancer 1980; 45: 996–1000.

    PubMed  CAS  Google Scholar 

  72. Brumback RA, Gerber JE, Hicks DG, et al: Adenocarcinoma of the stomach following irradiation and chemotherapy for lymphoma in young patients. Cancer 1984; 54: 994–998.

    PubMed  CAS  Google Scholar 

  73. Ménétrier P: Des polyadenomes gastriques et de leurs rapport avec le cancer de l’estomac. Arch Physiol Norm Pathol 1888; 1: 32–55.

    Google Scholar 

  74. Morson BC, Sobin LH, Grundmann E, et al: Precancerous conditions and epithelial dysplasia in the stomach. J Clin Pathol 1980; 33: 711–721.

    PubMed  CAS  Google Scholar 

  75. Nagayo T: Dysplasia of the gastric mucosa and its relation to the precancerous state. Gann 1981; 72: 813–823.

    PubMed  CAS  Google Scholar 

  76. Ming S-C, Bajtai A, Correa P, et al: Gastric dysplasia. Significance and pathologic cri-teria. Cancer 1984; 54: 1794–1801.

    PubMed  CAS  Google Scholar 

  77. Tosi P, Luzi P, Baak JPA, et al: Gastric dys-plasia: A stereological and morphometrical assessment. J Pathol 1987; 152: 83–94.

    PubMed  CAS  Google Scholar 

  78. Correa P, Cuello C, Dugue E, et al: Gastric cancer in Columbia. III. Natural history of precursor lesions. J Natl Cancer Inst 1976; 57: 1027–1035.

    PubMed  CAS  Google Scholar 

  79. Oehlert W, Keller P, Henke M, et al: Gastric mucosal dysplasia: What is its clinical significance? Front Gastrointest Res 1979; 4: 173–182.

    PubMed  CAS  Google Scholar 

  80. Hattori T: Histological and autoradiographic study on development of group III lesion (dysplasia grade III) in the stomach. Pathol Res Pract 1985; 180: 36–44.

    PubMed  CAS  Google Scholar 

  81. Jass JR, Filipe MI: The mucin profiles of normal gastric mucosa, intestinal metaplasia and its variants, and gastric carcinoma. Histochem J 1981; 13: 931–939.

    PubMed  CAS  Google Scholar 

  82. Iida F, Kusama J: Gastric carcinoma and intestinal metaplasia. Significances of types of intestinal metaplasia upon development of gastric carcinoma. Cancer 1982; 50: 2854–2858.

    PubMed  CAS  Google Scholar 

  83. Lei D-N, Yu J-Y: Types of mucosal metaplasia in relation to the histogenesis of gastric carcinoma. Arch Pathol Lab Med 1984; 108: 220–224.

    PubMed  CAS  Google Scholar 

  84. Skinner JM, Whitehead R: Tumor markers in carcinoma and premalignant states of the stomach in humans. Eur J Cancer Clin Oncol 1982; 18: 227–235.

    PubMed  CAS  Google Scholar 

  85. Higgins PJ, Correa P, Cuello C, et al: Fetal antigens in the precursor stages of gastric cancer. Oncology 1984; 41: 73–76.

    PubMed  CAS  Google Scholar 

  86. Stranignoni D, Coola R: Distribution of tumor-associated antigens in gastric lesions as detected by two monoclonal antibodies on tissue sections. Cancer Detect Prev 1985; 8: 193–206.

    Google Scholar 

  87. Kapadia A, Feizi T, Jewell D, et al: Immuno- cytochemical studies of blood group A H I, and i antigens in gastric mucosae of infants with normal gastric histology and of patients with gastric carcinoma and chronic benign peptic ulceration. J Clin Pathol 1981; 34: 320–337.

    PubMed  CAS  Google Scholar 

  88. Isaacson P: Immunoperoxidase study of the secretory immunoglobulin system and lysozyme in normal and diseased gastric mucosa. Gut 1982; 23: 578–588.

    PubMed  CAS  Google Scholar 

  89. Nagayo T: Histological diagnosis of biopsied gastric mucosae with special reference to that of borderline lesions. Gann 1971; 11: 245–256.

    Google Scholar 

  90. Grundmann E, Schlake W: Histology of possible precancerous stages in stomach, in Her- farth CH, Schlag P (eds): Gastric Cancer. Berlin: Springer-Verlag, 1979: 72–82.

    Google Scholar 

  91. Ming S-C: Dysplasia of gastric epithelium. Front Gastrointest Res 1979; 4: 164–172.

    PubMed  CAS  Google Scholar 

  92. Cuello C, Correa P, Zarama G, et al: Histo- pathology of gastric dysplasia: Correlations with gastric juice chemistry. Am J Surg Pathol 1979; 3: 491–500.

    PubMed  CAS  Google Scholar 

  93. Kunze E, Schauer A, Eder M, Seefeldt C: Early sequential lesions during development of experimental gastric cancer with a special reference to dysplasia. J Cancer Res Clin Oncol 1979; 95: 247–264.

    PubMed  CAS  Google Scholar 

  94. Farini R, Farinati F, Leandro G, et al: Gastric epithelial dysplasia in relapsing and non- relapsing gastric ulcer. Am J Gastroenterol 1982; 77: 844–853.

    PubMed  CAS  Google Scholar 

  95. Meister H, Holubarsch CH, Haferkamp O, et al: Gastritis, intestinal metaplasia, and dysplasia versus benign ulcer in stomach and duodenum and gastric carcinoma. A Histo- topographical study. Pathol Res Pract 1979; 164: 259–269.

    PubMed  CAS  Google Scholar 

  96. Newsletter of the Gastrointestinal Pathology Club 1985;3(2):20–27.

    Google Scholar 

  97. Jarvis LR, Whitehead R: Morphometric analysis of gastric dysplasia. J Pathol 1985; 147: 133–138.

    PubMed  CAS  Google Scholar 

  98. Nishizawa M, Okada T: Magnified observations of ulcerated borderline lesions (adenoma) of the stomach based on dissecting microscopy and magnifying fiberoptic endoscopy. Endoscopy 1981; 13: 234–237.

    PubMed  CAS  Google Scholar 

  99. Hirono M, Shimura K, Nagami K, et al: Macroscopic demonstration of atypical epithelial lesion of the stomach by the leucine amino- peptidase-alkaline phosphatase double staining method. Gann 1981; 72: 331–332.

    PubMed  CAS  Google Scholar 

  100. Rubio CA, Hirota T, Habashi T: Atypical mitoses in elevated dysplasias of the stomach. Pathol Res Pract 1985; 180: 372–376.

    PubMed  CAS  Google Scholar 

  101. Rubio CA, Kato Y, Sugano H: The intra- mucosal cysts of the stomach in Japanese subjects having focal (elevated) dysplasia. Gann 1983; 74: 391–397.

    PubMed  CAS  Google Scholar 

  102. Riemann JF, Schmidt H, Hermanek P: On the ultrastructure of the gastric “borderline lesion.” J Cancer Res Clin Oncol 1983; 105: 285–291.

    Google Scholar 

  103. Sipponen P: Intestinal metaplasia and gastric carcinoma. Ann Clin Res 1981; 13: 139–143.

    PubMed  CAS  Google Scholar 

  104. Bramesar KCR, Sanders DSA, Hopwood D: Limited value of type III intestinal metaplasia in predicting risk of gastric carcinoma. J Clin Pathol 1987; 40: 1287–1290.

    Google Scholar 

  105. Turani H, Lurie B, Chaimoff C, et al: The diagnostic significance of sulfated acid mucin content in gastric intestinal metaplasia with early gastric cancer. Am J Gastroenterol 1986; 81: 343–345.

    PubMed  CAS  Google Scholar 

  106. Huang C-B, Xu J, Huang J-F, et al: Sulphomucin colonic type intestinal metaplasia and carcinoma of the stomach. Cancer 1986; 57: 1370–1375.

    PubMed  CAS  Google Scholar 

  107. Matsukura N, Suzuki K, Kawachi T, et al: Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation of complete and incomplete types of intestinal metaplasia to minute gastric carcinomas. J Natl Cancer Inst 1980; 65: 231–236.

    PubMed  CAS  Google Scholar 

  108. Wurster K, Rapp W: Histological and immunohistological studies on gastric mucosa. I. The presence of CEA in dysplastic surface epithelium. Pathol Res Pract 1979; 164: 270–281.

    PubMed  CAS  Google Scholar 

  109. Feizi T: Blood group antigens and gastric cancer. Med Biol 1982; 60: 7–11.

    PubMed  CAS  Google Scholar 

  110. Weiss H, Wildner GP, Gütz H-J, et al: DNA distribution patterns of preneoplastic cells and their interpretation. Stomach and cervix uteri. Oncology 1981; 38: 210–218.

    PubMed  CAS  Google Scholar 

  111. Weidner N, Smith J, LaVanway JM: Peptic ulceration with marked epithelial atypia following hepatic arterial infusion chemo-therapy. Am J Surg Pathol 1983; 7: 261–268.

    PubMed  CAS  Google Scholar 

  112. Jewell LD, Fields AL, Murray CJW, et al: Erosive gastroduodenitis with marked epithelial atypia following hepatic arterial infusion chemotherapy. Am J Gastroenterol 1985; 80: 421–424.

    PubMed  CAS  Google Scholar 

  113. Bogomoletz WV: Early gastric cancer. Am J Surg Pathol 1984; 8: 381–391.

    PubMed  CAS  Google Scholar 

  114. Fernando SSE, Nakamura K: Japanese technique of early gastric cancer diagnosis. Am J Gastroenterol 1986; 81: 757–764.

    PubMed  CAS  Google Scholar 

  115. Murakami T: Early cancer of the stomach. World J Surg 1979; 3: 685–692.

    PubMed  CAS  Google Scholar 

  116. Morrissey JF: Mass screening for gastric cancer. Gastrointest Endosc 1982; 28: 112–113.

    PubMed  CAS  Google Scholar 

  117. Stout AP: Tumors of the stomach, in Atlas of Tumor Pathology, Section VI, Fascicle 21. Washington DC: Armed Forces Institute of Pathology, 1953.

    Google Scholar 

  118. Cancer statistics 1983. CA 1983; 33: 9–25.

    Google Scholar 

  119. Sowa M, Ohkita H, Nitta M, et al: Evaluation of clinicopathological analysis of the early gastric cancer. World J Surg 1981; 5: 717–720.

    PubMed  CAS  Google Scholar 

  120. Matsusaka T, Kodama Y, Soejima K, et al: Recurrence in early gastric cancer. A pathologic evaluation. Cancer 1980; 46: 168–172.

    PubMed  CAS  Google Scholar 

  121. Gebhardt C, Husemann B, Hermanek P, et al: Clinical aspects and therapy of early gastric cancer. World J Surg 1981; 5: 721–724.

    PubMed  CAS  Google Scholar 

  122. Tong-Hua L, Ming-Chang C: Carcinome gas- trique primitif. Analyse clinicopathologique de 50 cas. J Chir (Paris) 1982; 119: 105–113.

    CAS  Google Scholar 

  123. Takasugi T, Hirota T, Sasagawa M, et al: Actuarial survival rate of early gastric cancer. Stomach Intestine 1977; 12: 933.

    Google Scholar 

  124. Rösch W: Das Magenfrühkarzinom-spezielle geriatrische Probleme. Akt Gerontol 1981; 11: 57–59.

    Google Scholar 

  125. Green PHR, O’Toole KM, Weinberg LM, et al: Early gastric cancer. Gastroenterology 1981; 81: 247–256.

    PubMed  CAS  Google Scholar 

  126. Haubrich WS: “Early” gastric cancer. Gastrointest Endosc 1979;25:77–78.

    Google Scholar 

  127. Alampi G, Bazzocchi F, Briccoli A, et al: Considerazioni su 50 casi di early gastric cancer. Min Chir 1980; 35: 891–894.

    CAS  Google Scholar 

  128. Kawai K: Diagnosis of early gastric cancer. Endoscopy 1971; 1: 23–27.

    Google Scholar 

  129. Kawai K: Brief communication on early gastric cancer in Japan. ESGE News Lett 1978; 2: 13–14.

    Google Scholar 

  130. Yoshiaki I, Blackstone MO, Riddell RH, et al: The endoscopic diagnosis of early gastric cancer. Gastrointest Endosc 1979; 25: 96–100.

    Google Scholar 

  131. Goldstein F, Kline TS, Kline IK, et al: Early gastric cancer in a United States hospital. Am J Gastroenterol 1983; 78: 715–719.

    PubMed  CAS  Google Scholar 

  132. Rotterdam H, Zietz C: Changing incidence of early gastric cancer (abst). Lab Invest 1983; 48: 72A.

    Google Scholar 

  133. Evans DMD, Craven JL, Murphy F, et al: Comparison of early gastric cancer in Britain and Japan. Gut 1978; 19: 1–9.

    PubMed  CAS  Google Scholar 

  134. Fevre DI, Green PHR, Barratt PJ, et al: Review of five cases of early gastric carcinoma. Gut 1976; 17: 41–47.

    PubMed  CAS  Google Scholar 

  135. Ohman U, Ernas S, Rubio C: Relation between early and advanced cancer. Am J Surg 1980; 140: 351–355.

    PubMed  CAS  Google Scholar 

  136. Caduff B, Rüedi TH, Hartmann G, et al: Magenkarzinom-Fründiagnose: Realität oder Illusion? Schweiz Med Wschr 1982; 112: 526–528.

    PubMed  CAS  Google Scholar 

  137. Busuttil A, Webb JN: Early carcinoma of the stomach. J R Coll Surg Edinburgh 1981; 26: 322–327.

    CAS  Google Scholar 

  138. Tonghua L, Minzhang C: Early gastric carci¬noma. Clinicopathologic analysis of 50 cases. Chin Med J 1981; 94: 345–354.

    Google Scholar 

  139. Guangbi Y, Shuzong L, Buyue X: Clinical and endoscopic study of early gastric cancer. Report of 15 cases and review of Chinese literature. Aust NZ J Med 1982; 12: 284–286.

    CAS  Google Scholar 

  140. Eckstam EE: Early gastric cancer: report of 5 cases. Gastrointest Endosc 1981; 27: 174–175.

    PubMed  CAS  Google Scholar 

  141. Oohara T, Tbhma H, Takezoe K, et al: Minute gastric cancers less than 5 mm in diameter. Cancer 1982; 50: 801–810.

    PubMed  CAS  Google Scholar 

  142. Esaki Y, Hirokawa K, Yamashiro M: Multiple gastric cancers in the aged with special reference to intramucosal cancers. Cancer 1987; 59: 560–565.

    PubMed  CAS  Google Scholar 

  143. Tsukuma H, Mishima T, Oshima A: Prospective study of “early gastric cancer.” Int J Cancer 1983; 31: 421–426.

    PubMed  CAS  Google Scholar 

  144. Eckhardt VF, Willems D, Kanzler G, et al: Eighty months persistence of poorly differentiated early gastric cancer. Gastroenterology 1984; 87: 719–724.

    Google Scholar 

  145. Kobayashi S: Diagnosis of early gastric cancer of the upper stomach. Gastroenterol Endosc (Jpn) 1981; 23: 1108–1114.

    Google Scholar 

  146. Sakuma A, Ouchi A, Sugawara T, et al: Histologic infiltrating pattern of gastric microcar- cinoma by means of serial sections. Cancer 1985; 55: 1087–1092.

    PubMed  CAS  Google Scholar 

  147. Lehnert T, Erlandson RA, Decosse J J: Lymph and blood capillaries of the human gastric mucosa. A morphologic basis for metastasis in early gastric carcinoma. Gastroenterology 1985; 89: 939–950.

    PubMed  CAS  Google Scholar 

  148. Kodama Y, Inokuchi K, Soejima K, et al: Growth patterns and prognosis in early gastric carcinoma. Cancer 1983; 51: 320–326.

    PubMed  CAS  Google Scholar 

  149. Owen DA: Normal histology of the stomach. Am J Surg Pathol 1986; 10: 48–61.

    PubMed  CAS  Google Scholar 

  150. Miwak: Advances in treatment of stomach carcinoma in Japan, in Hirayana T (ed): Epidemiology of Stomach Cancer: Key Questions and Answers. Tokyo: WHO-CC Monograph, 1977: 109.

    Google Scholar 

  151. Inokuchi K, Kodama Y, Sasaki O, et al: Differentiation of growth patterns of early gastric carcinoma determined by cytophotometric DNA analysis. Cancer 1983; 51: 1138–1141.

    PubMed  CAS  Google Scholar 

  152. Oohara T, Aono G, Ukawa S, et al: Clinical diagnosis of minute gastric cancer less than 5 mm in diameter. Cancer 1984; 53: 162–165.

    PubMed  CAS  Google Scholar 

  153. Iishi H, Tatsuta M, Okuda S: Endoscopic diagnosis of minute gastric cancer of less than 5 mm in diameter. Cancer 1985; 56: 655–659.

    PubMed  CAS  Google Scholar 

  154. Tatsuta M, Okuda S, Tamura H, et al: Endoscopic diagnosis of early gastric cancer by the endoscopic Congo red-methylene blue test. Cancer 1982; 50: 2956–2960.

    PubMed  CAS  Google Scholar 

  155. Ikeda K, Sannohe V, Araki S, et al: Intra-arterial dye method with vasomotors (PIAD method) applied for the endoscopic diagnosis of gastric cancer and the side effects of indigo carmine. Endoscopy 1982; 14: 119–123.

    PubMed  CAS  Google Scholar 

  156. Elster K, Carson W, Wild A, et al: Evaluation of histological classification in early gastric cancer. Endoscopy 1979; 3: 203–206.

    Google Scholar 

  157. Ambe K, Mori M, Enjoji M: Early gastric carcinoma with multiple endocrine cell micronests. Am J Surg Pathol 1987; 11: 310–315.

    PubMed  CAS  Google Scholar 

  158. Czerniak B, Herz F, Koss LG: DNA distribu-tion patterns in early gastric carcinoma. Cancer 1987; 59: 113–117.

    PubMed  CAS  Google Scholar 

  159. Rubio CA, Ohman U: The intramucosal cysts of the stomach. Acta Pathol Microbiol Immunol Scand (A) 1982; 90: 363–366.

    CAS  Google Scholar 

  160. Lin C-C, Taki K, Kuwabara N, et al: The sig-nificance of submucosal fibrosis in mucosal carcinoma of the stomach. J Formosan Med Assoc 1981; 90: 93–103.

    Google Scholar 

  161. Rösch W, Frühmorgen P: Endoscopic treatment of precanceroses and early gastric carcinoma. Endoscopy 1980; 12: 109–113.

    PubMed  Google Scholar 

  162. Sakita T, Koyama S, Ishii M, et al: Early cancer of the stomach treated successfully with an endoscopic neodymium-YAG laser. Am J Gastroenterol 1981; 76: 441–445.

    PubMed  CAS  Google Scholar 

  163. Borrmann R: Geschwülste des Magens und Duodenums, in Henke F, Lubarsch O (eds): Handbuch der speziellen pathologischen Anatomie und Histologie, Vol 4. Berlin: Julius Springer, 1926: 812.

    Google Scholar 

  164. Schindler R, Steiner PF, Smith WM, et al: Classification of gastric carcinoma. Surg Gynecol Obstet 1941; 73: 30–39.

    Google Scholar 

  165. Ming SC: Gastric carcinoma. A pathobiologic classification. Cancer 1977; 39: 2475–2485.

    PubMed  CAS  Google Scholar 

  166. Curtis RE, Kennedy BJ, Myers MH, et al: Evaluation of AJC cancer staging using the SEER population. Semin Oncol 1985; 12: 21–31.

    PubMed  CAS  Google Scholar 

  167. Moss AA, Schnyder P, Marks W, et al: Gastric adenocarcinoma: A comparison of the accuracy and economics of staging by computed tomography and surgery. Gastroenterology 1981; 80: 45–50.

    PubMed  CAS  Google Scholar 

  168. Lauren P: The two histologic main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 1965; 64: 31–49.

    PubMed  CAS  Google Scholar 

  169. Noda S, Soejima K, Inokuchi K: Clinicopath- ological analysis of the intestinal type and diffuse type of gastric carcinoma. Jpn J Surg 1980; 10: 277–283.

    PubMed  CAS  Google Scholar 

  170. Antonioli DA: Current concepts in carcinoma of the stomach, in Appelman HD (ed): Pathology of the Esophagus, Stomach, and Duodenum. New York: Churchill Livingstone, 1984.

    Google Scholar 

  171. Mulligan RM: Histogenesis and biologic behavior of gastric carcinoma, in Sommers SC, (ed): Pathology Decennial 1966–1975. New York: Appleton-Century-Crofts, 1975: 31–102.

    Google Scholar 

  172. Ishii T, Ikegami N, Hosoda Y, et al: The biological behaviour of gastric cancer. J Pathol 1981; 134: 97–115.

    PubMed  CAS  Google Scholar 

  173. Weed TE, Nuessle W, Ochsner A: Carcinoma of the stomach. Why are we failing to improve survival? Ann Surg 1981; 193: 407–412.

    PubMed  CAS  Google Scholar 

  174. Tso PL, Bringaze WL, Dauterive AH, et al: Gastric carcinoma in the young. Cancer 1987; 59: 1362–1365.

    PubMed  CAS  Google Scholar 

  175. Douglass HO, Nova HR: Gastric adenocarcinoma-management of the primary disease. Semin Oncol 1985; 12: 32–45.

    PubMed  Google Scholar 

  176. Zimmerman SE, Smith FP, Philips TM, et al: Gastric carcinoma and thrombotic thrombo-cytopenic purpura: association with plasma immune complex concentrations. Br Med J 1982; 284: 1432–1434.

    CAS  Google Scholar 

  177. Pascal RR, Slovin SF: Tumor directed anti-body and carcinoembryonic antigen in the glomeruli of a patient with gastric carcinoma. Hum Pathol 1980; 11: 679–682.

    PubMed  CAS  Google Scholar 

  178. Wakashin M, Wakashin Y, Iesato K, et al: Association of gastric cancer and nephrotic syndrome. An immunologic study in three patients. Gastroenterology 1980; 78: 749–756.

    PubMed  CAS  Google Scholar 

  179. Andreev VC, Boyanov L, Tsankov N: Generalized acanthosis nigricans. Dermatologica 1981; 163: 19–24.

    PubMed  CAS  Google Scholar 

  180. Obara TO, Ito Y, Kodama T, et al: A case of gastric carcinoma associated with excessive granulocytosis. Cancer 1985; 56: 782–788.

    PubMed  CAS  Google Scholar 

  181. Tamburrano G, Tamburrano S, Natoli C, et al: Gastric carcinoma associated with severe hypoglycemia sensitive to diazoxide. Diabete Metab (Paris) 1979; 5: 287–291.

    CAS  Google Scholar 

  182. Bralow SP: Diagnosis and staging of esophageal and gastric cancer. Cancer 1982; 50: 2566–2570.

    PubMed  CAS  Google Scholar 

  183. Armstrong CP, Dent DM, Berman P, et al: The relationship between gastric carcinoma and gastric juice lactate (L and D) and lactate dehydrogenase. Am J Gastroenterol 1984; 79: 675–678.

    PubMed  CAS  Google Scholar 

  184. Williams GT, Rogers K: Elevated gastric juice enzymes-a marker for increased gastric cancer risk. Clin Oncol 1984; 10: 319–323.

    PubMed  CAS  Google Scholar 

  185. Nomura AMYk, Stemmermann GN, Samloff IM: Serum pepsinogen I as a predictor of stomach cancer. Ann Intern Med 1980; 93: 537–540.

    Google Scholar 

  186. Häkkinen IPT, Heinonen R, Inberg MV, et al: Clinicopathological study of gastric cancers and precancerous states detected by fetal sul- foglycoprotein antigen screening. Cancer Res 1980; 40: 4308–4312.

    PubMed  Google Scholar 

  187. Ishikura H, Fukasawa Y, Ogasawara K, et al: An AFP-producing gastric carcinoma with features of hepatic differentiation. A case report. Cancer 1985; 56: 840–848.

    PubMed  CAS  Google Scholar 

  188. Dittrich C, Havelec L, Breyer S, et al: Car-cinoembryonic (CEA) plasma level determi-nation in the management of gastric cancer patients. Cancer Detect Prev 1985; 8: 181–188.

    PubMed  CAS  Google Scholar 

  189. Keto P, Suoranta H, Ihamäki T, et al: Double contrast examination of the stomach com-pared with endoscopy. Acta Radiol Diagn (Stockh) 1979; 20 (5): 762–768.

    CAS  Google Scholar 

  190. Li DKB, Burhenne HJ: Computed tomogra-phy of the stomach and duodenum: A review. Am J Gastroenterol 1983; 78: 36–41.

    PubMed  CAS  Google Scholar 

  191. Freeny PC, Marks WM: Adenocarcinoma of the gastroesophageal junction: Barium and CT examination. AJR 1982; 138: 1077–1084.

    PubMed  CAS  Google Scholar 

  192. Shi Z-R, Cai D-I: Endoscopic diagnosis of gastric cancer: An analysis of 872 cases in China. Gastrointest Endosc 1985; 31: 191–193.

    PubMed  CAS  Google Scholar 

  193. Llanos O, Guzman S, Duarte I: Accuracy of the first endoscopic procedure in the differential diagnosis of gastric lesions. Ann Surg 1982; 193: 224–226.

    Google Scholar 

  194. Rösch W: Wandel gastroenterologischer Krankheitsbilder durch die Endoskopie. Z Gastroenterol 1982; 20: 257–262.

    PubMed  Google Scholar 

  195. Gupta JP, Jain AK, Agrawal BK, et al: Gas- troscopic cytology and biopsies in diagnosis of gastric malignancies. J Surg Oncol 1983; 22: 62–64.

    PubMed  CAS  Google Scholar 

  196. Carrera GF, Mascatello VJ, Holm H, et al: Ultrasonically guided percutaneous biopsy of gastric lesions. Wise Med J 1979; 78: 28–29.

    CAS  Google Scholar 

  197. Graham DY, Schwartz JT, Cain D, et al: Prospective evaluation of biopsy number in the diagnosis of esophageal and gastric carcinoma. Gastroenterology 1982; 82: 228–231.

    PubMed  CAS  Google Scholar 

  198. Young J, Hughes HE, Hole DJ: Morphological characteristics and distribution patterns of epithelial cells in the cytological diagnosis of gastric cancer. J Clin Pathol 1982; 35: 585–590.

    PubMed  CAS  Google Scholar 

  199. Shanghai Gastrointestinal Endoscopy Cooperative Group, People’s Republic of China: Value of biopsy and brush cytology in the diagnosis of gastric cancer. Gut 1982; 23: 774–776.

    Google Scholar 

  200. Lightdale C J, Sherlock P: The diagnosis and treatment of gastric malignancies. Front Gastrointest Res 1980; 6: 138–147.

    Google Scholar 

  201. Young JA, Hughes HE: Three year trial of endoscopic cytology of the stomach and duodenum. Gut 1980; 21: 241–246.

    PubMed  CAS  Google Scholar 

  202. Hanson JT, Thoreson C, Morrissey JF: Brush cytology in the diagnosis of upper gastrointestinal malignancy. Gastrointest Endosc 1980; 26: 33–35.

    PubMed  CAS  Google Scholar 

  203. Iishi H, Yanamoto R, Tatsuto M, et al: Evaluation of fine-needle aspiration biopsy under direct vision gastrofiberscopy in diagnosis of diffusely infiltrative carcinoma of the stomach. Cancer 1986; 57: 1365–1369.

    PubMed  CAS  Google Scholar 

  204. Gupta S, Annamma ML, Gupta S: Tetra-cycline fluorescence in gastric malignancy. Am J Gastroenterol 1979; 30: 17–18.

    CAS  Google Scholar 

  205. Brinton W: The Diseases of the Stomach. London: H Renshaw, 1859: 310.

    Google Scholar 

  206. Antonioli DA, Goldman H: Changes in the location and type of gastric adenocarcinoma. Cancer 1982; 50: 775–781.

    PubMed  CAS  Google Scholar 

  207. Haukland HH, Johnson JA, Eide JT: Carcinoma diagnosed in excised gastric ulcers. Acta Chir Scand 1981; 147: 439–443.

    PubMed  CAS  Google Scholar 

  208. Wong J, Ong GB: Gastric carcinoma developing in chronic gastric ulcer in the rat treated with N-methyl-N-nitro-N-nitrosoguanidine. J Surg Res 1980; 29: 445–450.

    Google Scholar 

  209. Mountford RA, Brown P, Salmon PR, et al: Gastric cancer detection in gastric ulcer disease. Gut 1980; 21: 9–17.

    PubMed  CAS  Google Scholar 

  210. Paterson M, Easton DF, Corbishley M, et al: Changing distribution of adenocarcinoma of the stomach. Br J Surg 1987; 74: 481–482.

    PubMed  CAS  Google Scholar 

  211. Evans OMD, Cleary BK: The sites of origin of gastric cancers and ulcers in relation to mucosal junctions and the lesser curvature. Invest Cell Pathol 1979; 2: 97–117.

    PubMed  CAS  Google Scholar 

  212. Yamagiwa H, Yoshimura H, Matsuzaki O, et al: Pathological study of multiple gastric carcinoma. Acta Pathol Jpn 1980; 30: 421–426.

    PubMed  CAS  Google Scholar 

  213. Welvaart K, Warnsinck HM: The incidence of carcinoma of the gastric remnant. J Surg Oncol 1982; 21: 104–106.

    PubMed  CAS  Google Scholar 

  214. Balfour DC: Factors influencing the life expectancy of patients operated on for gastric ulcers. Ann Surg 1922; 76: 405–408.

    PubMed  CAS  Google Scholar 

  215. Morgenstern L, Nicholls JC: Commentary in stump cancer following gastric surgery. World J Surg 1979; 3: 731–736.

    Google Scholar 

  216. Clark CG, Fresini A, Gledhill T: Cancer following gastric surgery. Br J Surg 1985; 72: 591–594.

    PubMed  CAS  Google Scholar 

  217. Klarfeld J, Resnick G: Gastric remnant carcinoma. Cancer 1979; 44: 1129–1133.

    PubMed  CAS  Google Scholar 

  218. Peitsch W, Becker H-D: Frequency and prognosis of gastric stump cancer. Front Gastrointest Res 1979; 5: 170–177.

    PubMed  CAS  Google Scholar 

  219. Nicholls JC: Stump cancer following gastric surgery. World J Surg 1979; 3: 731–736.

    PubMed  CAS  Google Scholar 

  220. Papachristou DN, Agnanti N, Fortner JG: Gastric carcinoma after treatment of ulcer. Am J Surg 1980; 139: 193–196.

    PubMed  CAS  Google Scholar 

  221. Schafer LW, Larson DE, Melton J, et al: The risk of gastric carcinoma after surgical treatment for benign ulcer disease. N Engl J Med 1983; 309: 1210–1213.

    PubMed  CAS  Google Scholar 

  222. Sandler RS, Johnson MD, Holland KL: Risk of stomach cancer after gastric surgery for benign conditions. Dig Dis Sci 1984; 29: 703–708.

    PubMed  CAS  Google Scholar 

  223. Graem N, Fischer AB, Hastrup N, et al: Mucosal changes of the Billroth II resected stomach. Acta Pathol Microbiol Scand (A) 1981; 89: 227–234.

    CAS  Google Scholar 

  224. Öst A, Ewerth S, Hellers G: Intestinal metaplasia in the gastric remnant following resection for benign ulcer disease. Acta Chir Scand (Suppl) 1980; 500: 23–27.

    Google Scholar 

  225. Langhans P, Heger RA, Hohenstein J, et al: Gastric stump carcinoma-new aspects de-duced from experimental results. Scand J Gastroenterol 1981; 16 (Suppl 67): 161–164.

    Google Scholar 

  226. Dahm K, Eichfuss HP, Koch W: Cancer of the gastric stump after Billroth II resection. Front Gastrointest Res 1979; 5: 164–169.

    PubMed  CAS  Google Scholar 

  227. Rakovec S, Kovic M: Predisposition of the resected stomach for malignancy. World J Surg 1981; 5: 725–727.

    PubMed  CAS  Google Scholar 

  228. Bogolometz WV, Potet F, Barge J, et al: Pathological features and mucin histochemistry of primary gastric stump carcinoma associated with gastritis cystica polyposa. Am J Surg Pathol 1985; 9: 401–410.

    Google Scholar 

  229. Takeda M, Gomi K, Lewis PL, et al: Two histologic types of early gastric carcinoma and their cytologic presentation. Acta Cytol 1981; 25: 229–236.

    PubMed  CAS  Google Scholar 

  230. Takahashi T, Iwama N: Three-dimensional microstructures of gastrointestinal tumors. Pathol Annu 1985; 20 (l): 419–440.

    PubMed  Google Scholar 

  231. Heitz PU, Wegmann W: Identification of neoplastic Paneth cells in an adenocarcinoma of the stomach using lysozyme as a marker and electronmicroscopy. Virchows Arch (A) Pathol Anat Histopathol 1980; 386: 107–116.

    CAS  Google Scholar 

  232. Kato Y, Kitagawa T, Nakamura K, et al: Changes in the histologic types of gastric carcinoma in Japan. Cancer 1981; 48: 2084–2087.

    PubMed  CAS  Google Scholar 

  233. Tatematsu M, Furihata C, Katsuyama T, et al: Gastric and intestinal phenotypic expres-sions of human signet ring cell carcinomas revealed by their biochemistry, mucin histo-chemistry, and ultrastructure. Cancer Res 1986; 46: 4866–4872.

    PubMed  CAS  Google Scholar 

  234. Montero C, Segura DI: Retrospective histo- chemical study of mucosubstances in adeno-carcinomas of the gastrointestinal tract. Histopathology 1980; 4: 281–291.

    PubMed  CAS  Google Scholar 

  235. Bur M, Franklin WA: Lectin binding to human gastric adenocarcinomas and adjacent tissues. Am J Pathol 1985; 119: 279–287.

    PubMed  CAS  Google Scholar 

  236. Tahara E, Ito H, Taniyama K, et al: Alpha1 antitrypsin, alpharantichymotrypsin, and alpha2-macroglobulin in human gastric carcinomas. Hum Pathol 1984; 15: 957–964.

    PubMed  CAS  Google Scholar 

  237. Ejeckam GC, Huang SN, McCaughey WTE, et al: Immunohistopathologic study on car- cinoembryonic antigen (CEA)-like material and immunoglobulin A in gastric malignancies. Cancer 1979; 44: 1606–1614.

    PubMed  CAS  Google Scholar 

  238. Radi MJ, Fenoglio-Preiser CM, Key CR, et al: Gastric carcinoma in the young: A clinico- pathological and immunohistochemical study. Am J Gastroenterol 1986; 81: 747–755.

    PubMed  CAS  Google Scholar 

  239. Tahara E, Ito H, Nakagani K, et al: Scirrhous argyrophil cell carcinoma of the stomach with multiple production of polypeptide hor-mones, amine, CEA, lysozyme, and HCG. Cancer 1982; 49: 1904–1915.

    PubMed  CAS  Google Scholar 

  240. Tahara E, Ito H, Shimamoto F, et al: Lyso-zyme in human gastric carcinoma. A retro-spective immunohistochemical study. Histo-pathology 1982; 6: 409–421.

    CAS  Google Scholar 

  241. Proks C, Feit V: Gastric carcinomas with argyrophil and argentaffin cells. Virchows Arch [Cell Pathol] 1982; 395: 201–206.

    CAS  Google Scholar 

  242. Murayama H, Kamio A, Imai T, et al: Gastric carcinoma with psammomatous calcification. Cancer 1982; 49: 78–79.

    Google Scholar 

  243. Hisao I, Yokozaki H, Hata J, et al: Glicentin- containing cells in intestinal metaplasia, adenoma, and carcinoma of the stomach. Virchows Arch (A) Pathol Anat Histopathol 1984; 404: 17–29.

    Google Scholar 

  244. Tari A, Miyachi Y, Hide M, et al: Beta endorphin-like immunoreactivity and soma- tostatin-like immunoreactivity in normal gastric mucosa, muscle layer, and adenocarcinoma. Gastroenterology 1985; 88: 670–674.

    PubMed  CAS  Google Scholar 

  245. Nishi K, Tokunaga A, Shimizu Y, et al: Immunohistochemical study of intracellular estradiol in human gastric cancer. Cancer 1987; 59: 1328–1332.

    PubMed  CAS  Google Scholar 

  246. Tbkunaga A, Nishi K, Matsukura N, et al: Estrogen and progesterone receptors in gastric cancer. Cancer 1986; 57: 1376–1379.

    Google Scholar 

  247. Tsujitani S, Furukawa T, Tamada R, et al: Langerhans cells and prognosis in patients with gastric carcinoma. Cancer 1987; 59: 501–505.

    PubMed  CAS  Google Scholar 

  248. Nevalainen TJ, Järvi OH: Ultrastructure of intestinal and diffuse type gastric carcinoma. J Pathol 1977; 22: 129–136.

    Google Scholar 

  249. Yamashiro K, Suzuki H, Nagayo T: Electron microscopic study of signet-ring cells in dif-fuse carcinoma of the human stomach. Virchows Arch (A) Pathol Anat Histopathol 1977; 374: 275–284.

    CAS  Google Scholar 

  250. Hattori T, Hosokawa Y, Fukuda M, et al: Analysis of DNA ploidy patterns of gastric carcinomas in Japanese. Cancer 1984; 54: 1591–1597.

    PubMed  CAS  Google Scholar 

  251. Hattori T, Hosokawa Y, Sugihara H, et al: DNA content of diffusely infiltrative carci-nomas in the stomach. Pathol Res Pract 1985; 180: 615–618.

    PubMed  CAS  Google Scholar 

  252. Korenaga D, Haraguchi M, Okamura T, et al: Consistency of DNA ploidy between primary and recurrent gastric carcinomas. Cancer Res 1986; 46: 1544–1546.

    PubMed  CAS  Google Scholar 

  253. Sasaki K, Takahashi M, Ogino T, et al: An autoradiographic study on the labeling index of biopsy specimens from gastric cancers. Cancer 1984; 54: 1307–1309.

    PubMed  CAS  Google Scholar 

  254. Brander WL, Needham PRG, Morgan AD: Indolent mucoid carcinoma of stomach. J Clin Pathol 1974; 27: 536–541.

    PubMed  CAS  Google Scholar 

  255. Libson E, Bloom RA, Blank P, et al: Calcified mucinous adenocarcinoma of the stomach- the CT appearances. Comput Radiol 1985; 9: 255–258.

    PubMed  CAS  Google Scholar 

  256. Saigo PE, Birgatti DJ, Sternberg S, et al: Primary gastric choriocarcinoma. Am J Surg Pathol 1981; 5: 333–342.

    PubMed  CAS  Google Scholar 

  257. Wurzl J, Brooks J J: Primary gastric choriocarcinoma. Cancer 1981; 48: 2756–2761.

    Google Scholar 

  258. Mari H, Soeda O, Kamano T, et al: Choriocar- cinomatous change with immunocytochemi- cally HCG-positive cells in the gastric carcinoma of the males. Virchows Arch (A) Pathol Anat Histopathol 1982; 396: 141–153.

    Google Scholar 

  259. Garcia RL, Ghali VS: Gastric choriocarcinoma and yolk sac tumor in a man: Observa-tions about its possible origin. Hum Pathol 1985; 16: 955–958.

    PubMed  CAS  Google Scholar 

  260. Kodama T, Kameya T, Hirota T, et al: Production of alpha-fetoprotein, normal serum pro-teins, and human chorionic gonadotropin in stomach cancer. Cancer 1981; 48: 1647–1655.

    PubMed  CAS  Google Scholar 

  261. Bonnheim DC, Sarac OK, Fett W: Primary squamous cell carcinoma of the stomach. Am J Gastroenterol 1985; 80: 91–94.

    PubMed  CAS  Google Scholar 

  262. Mari M, Iwashita A, Enjoji M: Squamous cell carcinoma of the stomach: Report of three cases. Am J Gastroenterol 1986; 81: 339–342.

    Google Scholar 

  263. Vaughan WP, Strauss FHH, Paloyan D: Squamous carcinoma of the stomach after luetic linitis plastica. Gastroenterology 1977; 72: 945–948.

    PubMed  CAS  Google Scholar 

  264. Eaton H, Tennekoon GE: Squamous carcinoma of the stomach following corrosive burns. Br J Surg 1972; 59: 382–387.

    PubMed  CAS  Google Scholar 

  265. Callery CD, Sanders MM, Pratt S, et al: Squamous cell carcinoma of the stomach: A study of four patients with common histogenesis. J Surg Oncol 1985; 29: 166–172.

    PubMed  CAS  Google Scholar 

  266. McLoughlin GA, Cave-Bigley GJ, Tagore L, et al: Cyclophosphamide and pure squamous cell carcinoma of the stomach. Br Med J 1980; 280: 524–525.

    PubMed  CAS  Google Scholar 

  267. Aoki Y, Tabuse K, Wada M, et al: Primary adenosquamous carcinoma of the stomach: Experiences of 11 cases and its clinical analyses. Gastroenterol Jpn 1978; 13: 140–145.

    PubMed  CAS  Google Scholar 

  268. Mari M, Iwashita A, Enjoji M: Adenosqua-mous carcinoma of the stomach: A clinico- pathologic analysis of 28 cases. Cancer 1986; 57: 333–339.

    Google Scholar 

  269. Spagnolo DV, Heenan PJ: Collision carci-noma at the esophagogastric junction. Cancer 1980; 46: 2702–2708.

    PubMed  CAS  Google Scholar 

  270. Prade M, Bara J, Gadenne C, et al: Gastric carcinoma with argyrophilic cells: Light mi-croscopic, electronmicroscopic, and immunochemical study. Hum Pathol 1982; 13: 588–592.

    PubMed  CAS  Google Scholar 

  271. Chejfec G, Capeila C, Solcia E, et al: Amphi- crine cells, dysplasia, and neoplasia. Cancer 1985; 56: 2683–2690.

    PubMed  CAS  Google Scholar 

  272. Eimoto T, Hayakawa H: Oat cell carcinoma of the stomach. Pathol Res Pract 1980; 168: 229–236.

    PubMed  CAS  Google Scholar 

  273. Capella C, Frigerio B, Cornaggia M, et al: Gastric parietal cell carcinoma-a newly rec-ognized entity: Light microscopic and ultra- structural features. Histopathology 1984; 8: 8131–824.

    Google Scholar 

  274. Bansal M, Kaneko M, Gordon RE: Carcinosarcoma and separate carcinoid tumor of the stomach. Cancer 1982; 50: 1876–1881.

    PubMed  CAS  Google Scholar 

  275. Hanada M, Nakano K, Ii Y, etal: Carcinosar-coma of the stomach. Acta Pathol Jpn 1985; 35: 951–959.

    PubMed  CAS  Google Scholar 

  276. Queckenstedt HHG: Über Karzinosarkome. Leipzig, 1904 (reference from Bansal etal.274)

    Google Scholar 

  277. Kohli Y, Kawai K, Fujita S: Analytical studies on growth of human gastric cancer. J Clin Gastroenterol 1981; 3: 129–133.

    PubMed  CAS  Google Scholar 

  278. Papachristou DN, Karas M, Fortner JG: Anastomotic recurrence in the esophagus complicating gastrectomy for adenocarci-noma of the stomach. Br J Surg 1979; 66: 609–612.

    PubMed  CAS  Google Scholar 

  279. Keighley MRB, Moore J, Lee JR, et al: Pre-operative frozen section and cytology to assess proximal invasion in gastroesopha-geal carcinoma. Br J Surg 1981; 68: 73–74.

    PubMed  CAS  Google Scholar 

  280. Menuck L: Transpyloric extension of gastric carcinoma. Dig Dis 1978; 23: 269–274.

    CAS  Google Scholar 

  281. Harper TG, Sperling HV, Easier RE: Linitis plastica involving the entire gastrointestinal tract. J Clin Gastroenterol 1982; 6: 29–33.

    Google Scholar 

  282. Flatau E, Resnitzky P, Griehkan A, et al: Linitis plastica infiltrating the entire gut. Am J Gastroenterol 1982; 77: 559–560.

    PubMed  CAS  Google Scholar 

  283. Mallaiah L, Fruchter G, Brozinsky S, et al: Malignant gastrocolic fistula. Case report and review of the literature. Am J Gastroenterol Colon Rect Surg 1980; 31: 12–17.

    CAS  Google Scholar 

  284. Shoji S, Soeno T, Takahashi T: Case of spontaneous gastrojejunal fistula due to gastric cancer. Am J Gastroenterol 1981; 75: 218–221.

    PubMed  CAS  Google Scholar 

  285. Kiyasu Y, Kanestima S, Koga S: Morphogenesis of peritoneal metastasis in human gastric cancer. Cancer Res 1981; 41: 1236–1239.

    PubMed  CAS  Google Scholar 

  286. Iitsuka Y, Kaneshima S, Tanida O, et al: Intraperitoneal free cancer cells and their viability in gastric cancer. Cancer 1979; 40: 1476–1480.

    Google Scholar 

  287. Duarte I, Lianas O: Patterns of metastases in intestinal and diffuse types of carcinoma of the stomach. Hum Pathol 1981; 12: 237–242.

    PubMed  CAS  Google Scholar 

  288. del Regato JA, Spjut HJ: Cancer, Diagnosis, Treatment, and Prognosis, 5th ed. St. Louis: CV Mosby, 1977

    Google Scholar 

  289. Libson E, Bloom RA, Halpern I, et al: Mediastinal lymph node metastases from gastrointestinal carcinoma. Cancer 1987; 59: 1490–1493.

    PubMed  CAS  Google Scholar 

  290. Tesar PJ, Goy J, Maynard J: Lymphangitis carcinomatosa. Med J Austral 1981; 1: 80–81.

    PubMed  CAS  Google Scholar 

  291. Bardram L, Jensen NB, Pedersen T: Breast tumour. An unusual manifestation of a carcinoma of the stomach. Acta Chir Scand 1982; 148: 389–392.

    PubMed  CAS  Google Scholar 

  292. Krukenberg F: Über das Fibrosarcoma Ovarii Mucocellulare (carcinomatoides). Arch Gynaekol 1896; 50: 287–295.

    Google Scholar 

  293. Schlagenhaufer F: Über das metastatische Ovarialkarzinom nach Krebs des Magens, Darmes und anderer Bauchorgane. Monats- schr Geburtshilfe Gynaekol 1902; 15: 485–494.

    Google Scholar 

  294. Novak C, Gray LA: Krukenberg tumor of the ovary: Clinical and pathological study of 21 cases. Surg Gynecol Obstet 1938; 66: 157–165.

    Google Scholar 

  295. Woodruff JD, Novak ER: Krukenberg tumor: A study of 48 cases from the ovarian tumor registry. Obstet Gynecol 1960; 15: 351–360.

    PubMed  CAS  Google Scholar 

  296. Metz SA, Karnei RF, Veach SR, et al: Krukenberg carcinoma of the ovary with bone marrow involvement. Obstet Gynecol 1980; 55: 99–104.

    PubMed  CAS  Google Scholar 

  297. Karsh J: Secondary malignant disease of the ovaries. Am J Obstet Gynecol 1951; 61: 154–160.

    PubMed  CAS  Google Scholar 

  298. Carstens SA, Resnick D: Diffuse sclerotic skeletal metastases as an initial feature of gastric carcinoma. Arch Intern Med 1980; 140: 1666–1688.

    PubMed  CAS  Google Scholar 

  299. Uchida T, Shikata T, Shimizu S-I, et al: Gonadotropin and alkaline phosphatase producing occult gastric carcinoma with widespread metastasis of generalized bone. Cancer 1981; 48: 140–150.

    PubMed  CAS  Google Scholar 

  300. McCrary JA, Patrinely JR, Font RL: Progressive blindness caused by metastatic occult signet-ring cell gastric carcinoma. Arch Ophthalmol 1986; 104: 410–413.

    PubMed  Google Scholar 

  301. Oesterwitz H, Bick C: Ureteral obstruction as primary manifestation of metastasizing gastric carcinoma. Int Urol Nephrol 1981; 13: 123–126.

    PubMed  CAS  Google Scholar 

  302. von Seters AP, Bots GT AM, van Dülken H, et al: Metastasis of an occult gastric carcinoma suggesting growth of a prolactinoma during bromocriptine therapy: A case report with a review of the literature. Neurosurgery 1985; 16: 813–817.

    PubMed  Google Scholar 

  303. Bizer LS: Adenocarcinoma of the stomach: Current results of treatment. Cancer 1983; 51: 743–745.

    PubMed  CAS  Google Scholar 

  304. Du Pont JB, Lee JR, Burton GR, et al: Adenocarcinoma of the stomach: Review of 1497 cases. Cancer 1978; 41: 941–947.

    Google Scholar 

  305. Yap P, Pantangco E, Yap A, et al: Surgical management of gastric carcinoma. Am J Surg 1982; 143: 284–287.

    PubMed  CAS  Google Scholar 

  306. ReMine WH: Indications and contraindications for surgery in gastric carcinoma. World J Surg 1979; 6: 709–714.

    Google Scholar 

  307. Shiu MH, Papachristou DN, Kosloff C, et al: Selection of operative procedures for adenocarcinoma of the midstomach. Ann Surg 1980; 192: 730–737.

    PubMed  CAS  Google Scholar 

  308. Tobe T, Hikasa Y, Matsuda S, et al: Treatment of gastric cancer with combined surgery and intraoperative radiotherapy. World J Surg 1979; 3: 715–719.

    PubMed  CAS  Google Scholar 

  309. Gastrointestinal Tumor Study Group: A comparison of combination chemotherapy and combined modality therapy for locally advanced gastric carcinoma. Cancer 1982; 49: 1771–1777.

    Google Scholar 

  310. Fleischer D, Sivak MU: Endoscopic Nd:YAG laser therapy as palliative treatment for advanced adenocarcinoma of the cardia. Gastroenterology 1984; 87: 815–820.

    PubMed  CAS  Google Scholar 

  311. Fleischer D, Sivak MU: Endoscopic Nd:YAG laser therapy as palliative treatment for advanced adenocarcinoma of the cardia. Gastroenterology 1984; 87: 815–820.

    PubMed  CAS  Google Scholar 

  312. Nielsen J, Aagaard J, Toftgaard C: Gastric cancer with special reference to prognostic factors. Acta Chir Scand 1985; 151: 49–55.

    PubMed  CAS  Google Scholar 

  313. Ziliotto A, Kunzle JE,, de Souza A et al: Evolutive and prognostic aspects in gastric cancer. Analysis of 189 cases. Cancer 1987; 59: 811 - 817.

    PubMed  Google Scholar 

  314. Danova M, Riccardi A, Mazzini G, et al: Flow cytometric analysis of paraffin-embedded material in human gastric cancer. Analy and Quant Cytol Histol 1988; 10: 200–206.

    CAS  Google Scholar 

  315. Haraguchi M, Okamura T, Korenaga D, et al: Heterogeneity of DNA ploidy in patients with undifferentiated carcinomas of the stomach. Cancer 1987; 59: 922–924.

    PubMed  CAS  Google Scholar 

  316. Zacho Z, Fischermann K, S0rensen BL: Prognostic role of breach of lymph node capsule in nodal metastases from gastric carcinoma. Acta Chir Scand 1963; 125: 365–369.

    PubMed  CAS  Google Scholar 

  317. Riegrova D, Jansa P: Prognostic significance of reactive changes in regional lymph nodes in gastric and mammary carcinomas. Neoplasia 1982; 29: 481–486.

    CAS  Google Scholar 

  318. Willis RA: The Spread of Tumours in the Human Body. London: Butterworth, 1952: 216–217.

    Google Scholar 

  319. Berge T, Lundberg S: Cancer in Malmo, 1958-1969. An autopsy study. Acta Pathol Microbiol Scand (Suppl) 1977; 260: 1–235.

    Google Scholar 

  320. Menuck LS, Amberg JR: Metastatic disease involving the stomach. Am J Dig Dis 1974; 20: 903–913.

    Google Scholar 

  321. Kibsgaard K: Gastric metastases from mucoepidermoid parotid tumor. Endoscopic diagnosis. Gastrointest Endosc 1979; 25: 106–107.

    PubMed  CAS  Google Scholar 

  322. Sandler RS, Sartar B, Bozymski EM: Endo-scopic appearance of cancer metastatic to the stomach. J Clin Gastroenterol 1981; 3 (suppl l): 35–37.

    PubMed  Google Scholar 

  323. Fleck RM, Schade RR, Kowai CD, et al: Tes-ticular choriocarcinoma with metastasis to gastric mucosa. Gastrointest Endosc 1984; 30: 188–189.

    PubMed  CAS  Google Scholar 

  324. Tawney S, Berger HW, Jayamanne DS, et al: Bronchogenic carcinoma with symptomatic metastasis to the stomach: A case report. Mt Sinai J Med 1982; 49: 338–340.

    PubMed  CAS  Google Scholar 

  325. Sullivan WG, Cabot EB, Donohue RE: Meta-static renal cell carcinoma to stomach. Urology 1980; 15: 375–378.

    PubMed  CAS  Google Scholar 

  326. Cormier WJ, Gaffey TA, Welch JS, et al: Linitis plastica caused by metastatic lobular carcinoma of the breast. Mayo Clin Proc 1980; 55: 747–753.

    PubMed  CAS  Google Scholar 

  327. Ochsner A, DeBakey M: Significance of metastasis in primary carcinomas of the lungs: Report of two cases with unusual site of metastasis. J Thorac Surg 1942; 11: 357–387.

    Google Scholar 

  328. Morini S, Bassi O, Colavolpe V: Malignant melanoma metastatic to the stomach. Endoscopic diagnosis and findings. Endoscopy 1980; 12: 86–89.

    PubMed  CAS  Google Scholar 

  329. Saito T, Iizuka T, Kato H, et al: Esophageal carcinoma metastatic to the stomach. A clinicopathologic study of 35 cases. Cancer 1985; 56: 2235–2241.

    PubMed  CAS  Google Scholar 

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Rotterdam, H., Enterline, H.T. (1989). Carcinoma of the Stomach. In: Pathology of the Stomach and Duodenum. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3550-7_7

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