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Interneuronal Communication II: Neurotransmitter Receptors and Second Messenger Systems

  • Oswald Steward

Abstract

Neurotransmitters are not inherently excitatory or inhibitory; in fact, certain neurotransmitters are excitatory in some situations and inhibitory in others. The action of a neurotransmitter depends upon its postsynaptic receptor and the intracellular processes that are influenced by the receptor. As noted in Chapter 3, it is useful to distinguish between two general classes of receptors: those linked to or part of ion channels (ionophore-linked) and those coupled to second messenger-generating systems (second messenger-linked). These will be considered separately.

Keywords

NMDA Receptor Excitatory Amino Acid Glycine Receptor Phosphatidyl Inositol Perforant Path 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Supplemental Reading

General

  1. McGeer PL, Eecles JC, McGeer EG (1987) Molecular Neurobiology of the Mammalian Brain. New York, Plenum PressGoogle Scholar

Ionophore-Linked Receptors

  1. Changeux J-P (1987) The acetylcholine receptor molecule: allosteric sites and the ion channel. Trends Neurosci 6:247–251 Google Scholar
  2. Foster AC, Fagg GE (1987) Taking apart NMDA receptors. Nature 329:395–396Google Scholar
  3. Grenningloh G, Rienitz A, Schmitt B et al. (1987) The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature 328:215–220PubMedCrossRefGoogle Scholar
  4. Schofield PR, Darlison MG, Fujita N et al. (1987) Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family. Nature 328:221–227PubMedCrossRefGoogle Scholar

Second Messenger Cascades

  1. Berridge MJ (1984) Biochem J 220:345–360PubMedGoogle Scholar
  2. Greengard P (1979) Cyclic nucleotides, phosphorylated proteins, and the nervous system. Fed Proc 38:2208–2217PubMedGoogle Scholar
  3. Hemmings HC Jr, Walaas SI, Ouimet CC et al. (1987) Dopaminergic regulation of protein phosphorylation in the striatum: DARPP-32. Trends Neurosci 10:377–382CrossRefGoogle Scholar
  4. Dunlap K, Holz GG, Rane SG (1987) G proteins as regulators of ion channel function. Trends Neurosci 10:244–247CrossRefGoogle Scholar
  5. Nishizuka Y (1984) Turnover of inositol phospholipids and signal transduction. Science 225:1365–1369PubMedCrossRefGoogle Scholar
  6. Nishizuka Y (1984) The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 308/19:693–697PubMedCrossRefGoogle Scholar

Second Messengers and Functional Modifications

  1. Brunelli M, Castellucci V, Kandel ER (1976) Synaptic facilitation and behavioral sensitization in Aplysia: possible role of serotonin and cyclic AMP. Science 194:1178–1181PubMedCrossRefGoogle Scholar
  2. Goelet P, Castellucci VF, Schacher S et al. (1986) Nature 322:419–422PubMedCrossRefGoogle Scholar
  3. Kandel ER, Schwartz JH (1982) Molecular biology of learning: modulation of transmitter release. Science 218:433–443PubMedCrossRefGoogle Scholar
  4. Nestler EJ, Greengard P (1983) Protein phosphorylation in the brain. Nature 305:583–589PubMedCrossRefGoogle Scholar

Long-term Potentiation

  1. Bliss TVP, Gardner-Medwin AR (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the unanesthetized rabbit following stimulation of the perforant path. J Physiol 232:357–374PubMedGoogle Scholar
  2. Bliss TVP, Lomo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulation of the perforant path. J Physiol 232:334–356Google Scholar
  3. Smith SJ (1987) Progress on LTP at hippocampal synapses: a postsynaptic Ca2+ trigger for memory storage. Trends Neurosci 10:142–144CrossRefGoogle Scholar

Cellular Mechanisms of Receptor Synthesis and Turnover

  1. Bursztajn S, Fischbach GD (1984) Evidence that coated vesicles transport acetylcholine receptors to the surface membrance of chick myotubes. J Cell Biol 98:498–506PubMedCrossRefGoogle Scholar
  2. Devreotes PN, Fambrough DM (1976) Synthesis of acetylcholine receptors by cultured chick myotubes and denervated mouse extensor digitorum longus muscles. Proc Natl Acad Sci USA 73:161–164PubMedCrossRefGoogle Scholar
  3. Merlie JP, Sanes JR (1985) Concentration of acetylcholine receptor mRNA in synaptic regions of adult muscle fibers. Nature 317:66–67PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Oswald Steward
    • 1
  1. 1.Department of NeuroscienceUniversity of Virginia, School of MedicineCharlottesvilleUSA

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