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Pharmacotherapy Trials in Posttraumatic Stress Disorder: Prospects and Problems

  • Bernard Lerer
  • Peter Braun
  • Avraham Bleich
  • Haim Dasberg
  • David Greenberg
Chapter

Abstract

Although a clinical symptom picture resembling the currently accepted DSM-III diagnosis of posttraumatic stress disorder (PTSD) has been recognized for decades, focused trials of psychopharmacological agents are a relatively recent development. The initial report by Hogben and Cornfield1 of a dramatic effect of treatment with the monoamine oxidase inhibitor phenelzine in patients with “traumatic war neurosis” has been followed by a spate of positive reports. These reports have attributed beneficial effects to a variety of drugs including tricyclic antidepressants,2,3 the limbic anticonvulsant carbamazepine,4 and the β-receptor blocker propranolol.5 Contrary to these generally optimistic reports, our experience with psychotropic agents in Israeli samples of PTSD patients has been less encouraging. This experience has been for the most part prospective and, in two studies, double-blind in nature using a drug/placebo crossover design.

Keywords

Ptsd Symptom Panic Disorder Post Traumatic Stress Disorder Ptsd Patient Psychotropic Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Bernard Lerer
  • Peter Braun
  • Avraham Bleich
  • Haim Dasberg
  • David Greenberg

There are no affiliations available

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