Abstract
In rodents the psychopharmacological profile of β-adrenergic stimulants is similar to that of classical antidepressants on a battery of tests used for screening antidepressant drugs1 (Table 7.1). One exception is the behavioral despair test, on which none of the β-adrenergic stimulants act. Two behavioral effects are shared by β-adrenergic stimulants and not by tricyclic antidepressants: decreased interest for food in mice starved for 24 h and decrease in spontaneous motor activity in rats and mice.
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References
Frances H, Poncelet M, Danti S, et al. Psychopharmacological profile of clenbuterol. Drug Dev Res 1983; 3: 349–356.
Souto M, Frances H, Lecrubier Y, et al. Antagonism by d-1-propranolol of imipramine effects in animals. Eur J Pharmacol 1979; 60: 105–108.
Frances H, Bulach C, Simon P, et al. Chronic beta-adrenergic stimulation increases in mice the sensitivity to methysergide and the number of cerebral high affinity serotonin binding sites (5-HT-1). J Neural Transm 1986; 67: 215–224.
Frances H, Raisman R, Simon P, et al. Lesions of the serotonergic system impair the facilitation of but not the tolerance to the effects of chronic clenbuterol administration. Psychopharmacology 1987; 91: 496–499.
Lecrubier Y, Jouvent R, Puech AJ, et al. Effect antidépresseur d’un stimulant bêta-adrenergique. Nouv Presse Med 1977; 6: 2786.
Lecrubier Y, Puech AJ, Jouvent R, et al. A beta-adrenergic stimulant (salbutamol) versus clomipramine in depression: a controlled study. Br J Psychiatry 1980; 136: 354–358.
Simon P, Lecrubier Y, Jouvent R, et al. Beta-receptor stimulation in the treatment of depression. In Usdin E, et al (eds): Frontiers in Biochemical and Pharmacological Research in Depression. New York: Raven Press, 1984.
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© 1989 Springer-Verlag New York Inc.
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Frances, H., Simon, P., Lecrubier, Y., Widlöcher, D. (1989). Behavioral Pharmacology and Clinical Antidepressant Effects of β-Adrenergic Agonists. In: Lerer, B., Gershon, S. (eds) New Directions in Affective Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3524-8_7
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DOI: https://doi.org/10.1007/978-1-4612-3524-8_7
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