In 1972 the serum thyrotropin (thyroid-stimulating hormone; TSH) response to thyrotropin-releasing hormone (TRH) was reported to be blunted in some euthyroid patients with major depression.1 Since then approximately 60 studies involving well over 1,000 patients have confirmed that several types of psychiatric illness are associated with a blunted TSH response to TRH. It is now established as one of the most consistent findings in biological psychiatry with profound clinical and theoretical implications. (For reviews see references 2,3.)
KeywordsDepression Dopamine Dementia Cortisol Aspirin
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- 6.Kjellman BG: The function of the hypothalamic-pituitary-thyroid axis in affective disorders. Thesis, Karolinska Institute, Department of Psychiatry and Medicine, St. Goran’s Hospital, Stockholm, and University of Linkoping, Stockholm, 1983.Google Scholar