TRH Stimulation Test in Psychiatry

  • Peter Herridge
  • Mark S. Gold


In 1972 the serum thyrotropin (thyroid-stimulating hormone; TSH) response to thyrotropin-releasing hormone (TRH) was reported to be blunted in some euthyroid patients with major depression.1 Since then approximately 60 studies involving well over 1,000 patients have confirmed that several types of psychiatric illness are associated with a blunted TSH response to TRH. It is now established as one of the most consistent findings in biological psychiatry with profound clinical and theoretical implications. (For reviews see references 2,3.)


Depression Dopamine Dementia Cortisol Aspirin 


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    Prange AJ Jr, Wilson IC, Lara PO, et al.: Effect of thyrotropin-releasing hormone in depression. Lancet 1972; 2: 999–1002.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Peter Herridge
  • Mark S. Gold

There are no affiliations available

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