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Effects of Lithium Ions on the Metabolism of Phosphoinositides

  • D. van Calker
  • W. Greil
Chapter

Abstract

The possibility that the therapeutic and prophylactic properties of lithium ions may be explained at least in part by their unique effects on the metabolism of phosphoinositides has attracted much attention. A decrease in the inositol content and a concomitant increase in the inositol-monophosphate concentration in the brain of lithium-treated animals was identified during the 1970s.1,2 However, only the elucidation of the pivotal role of phosphoinositide-derived second messenger molecules has allowed us to realize the significance of these findings (for reviews see refs. 3–6).

Keywords

Lithium Salt Messenger Molecule Adenylate Cyclase System Prophylactic Property Inositol Content 
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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • D. van Calker
  • W. Greil

There are no affiliations available

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