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Relation Between m-Cholinoceptor Density on Human Blood Cells and Psychological Predisposition Factors for Depression

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New Directions in Affective Disorders

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Abstract

A variety of experimental evidence indicate that disturbances of cholinergic neurotransmission are involved in the etiology of affective disorders, with some evidence for sensitivity changes at the level of the central muscarinic cholinergic receptors.1–3 However, direct experimental evidence for this hypothesis is still missing, as a suitable model to study m-cholinoceptor sensitivity in man and especially in psychiatric patients is not available. Accordingly, we have started to investigate the use of human blood cells as easily accessible tissues to study the properties of m-cholinoceptors in man.4,5

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References

  1. Janowski DS, El-Yousef ML, Davis JM, et al. A cholinergic-adrenergic hypothesis of mania and depression. Lancet 1972; 2: 632–635.

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  2. Sitaram N, Nuraberger JI Jr, Gershon ES, et al. Cholinergic regulation of mood and REM sleep: potential model and marker of vulnerability to affective disorders. Am J Psychiatry 1982; 139: 571–576.

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Authors
  1. Walter E. Müller
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  2. Birgit Bering
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  3. Hans W. Moises
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Editor information

Editors and Affiliations

  1. Jerusalem Mental Health Center-Ezrath Nashim, 91001, Jerusalem, Israel

    Bernard Lerer M.D. (Director of Research, Associate Professor) (Director of Research, Associate Professor)

  2. Department of Psychiatry, Hebrew University, 91001, Jerusalem, Israel

    Bernard Lerer M.D. (Director of Research, Associate Professor) (Director of Research, Associate Professor)

  3. University of Pittsburgh, 15213, Pittsburgh, PA, USA

    Samuel Gershon M.D. (Vice President for Research in the Medical and Health Care Division; Associate Vice President for Research in the Health Sciences, Professor of Psychiatry, Associate Research Director for Neurosciences) (Vice President for Research in the Medical and Health Care Division; Associate Vice President for Research in the Health Sciences, Professor of Psychiatry, Associate Research Director for Neurosciences)

  4. Department of Psychiatry, University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA

    Samuel Gershon M.D. (Vice President for Research in the Medical and Health Care Division; Associate Vice President for Research in the Health Sciences, Professor of Psychiatry, Associate Research Director for Neurosciences) (Vice President for Research in the Medical and Health Care Division; Associate Vice President for Research in the Health Sciences, Professor of Psychiatry, Associate Research Director for Neurosciences)

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© 1989 Springer-Verlag New York Inc.

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Müller, W.E., Bering, B., Moises, H.W. (1989). Relation Between m-Cholinoceptor Density on Human Blood Cells and Psychological Predisposition Factors for Depression. In: Lerer, B., Gershon, S. (eds) New Directions in Affective Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3524-8_16

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  • DOI: https://doi.org/10.1007/978-1-4612-3524-8_16

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-96769-1

  • Online ISBN: 978-1-4612-3524-8

  • eBook Packages: Springer Book Archive

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