Antidepressant Therapies for Treatment of Anorexia Nervosa and Bulimia Nervosa

  • Sidney H. Kennedy


Several authors have enthusiastically argued that a decrease in binge activity after antidepressants supports claims for a common origin to bulimia and affective disorder. The perils of such an argument are well illustrated in the model of diuretic treatment for congestive heart failure (CHF). Using the above logic, CHF would then be a disorder of renal origin.


Anorexia Nervosa Eating Disorder Affective Disorder Binge Eating Bulimia Nervosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Pyle RL, Mitchell JE, Eckert ED. Bulimia: a report of 34 cases. J Clin Psychiatry 1981; 42: 60–64.PubMedGoogle Scholar
  2. 2.
    Piran N, Kennedy S, Garfinkel PE, et al. Affective disturbances in eating disorders. J Nerv Ment Dis 1985;173:395–400.PubMedCrossRefGoogle Scholar
  3. 3.
    Hudson JI, Pope HG Jr, Jonas JM, et al. Phenomenological relationship of eating disorders to major affective disorder. Psychiatry Res 1983; 9: 345–354.PubMedCrossRefGoogle Scholar
  4. 4.
    Gershon ES, Schreiber JL, Hamovit JR, et al. Clinical findings in patients with anorexia nervosa and affective illness in their relatives. Am J Psychiatry 1984; 141: 1419–1422.PubMedGoogle Scholar
  5. 5.
    Strober M, Salkin B, Burroughs J, et al. Validity of the bulimia-restricter distinction in anorexia nervosa: parental personality characteristics and family psychiatric morbidity. J Nerv Ment Dis 1982; 170: 345–351.PubMedCrossRefGoogle Scholar
  6. 6.
    Strober M, Morrell W, Burroughs J, et al. A controlled family study of anorexia nervosa. J Psychiatr Res 1985; 19: 239–246.PubMedCrossRefGoogle Scholar
  7. 7.
    Holland AJ, Hall A, Murray R, et al. Anorexia nervosa: a study of 34 twin pairs and one set of triplets. Br J Psychiatry 1984; 145: 414–419.PubMedCrossRefGoogle Scholar
  8. 8.
    Biederman J, Rivinus TM, Herzog DB, et al. High frequency of HLA Bw16 in patients with anorexia nervosa. Am J Psychiatry 1984; 141: 1109–1110.PubMedGoogle Scholar
  9. 9.
    Needleman HL, Waber D. Amitriptyline therapy in patients with anorexia nervosa. Lancet 1976; 134: 1303–1304.Google Scholar
  10. 10.
    Lacey JH, Crisp AH. Hunger, food intake and weight: the impact of clomipramine on a refeeding anorexia nervosa population. Postgrad Med J 1980; 56: 79–85.PubMedGoogle Scholar
  11. 11.
    Biederman J, Herzog DB, Rivinus TM, et al. Amitriptyline in the treatment of anorexia nervosa: a double-blind, placebo-controlled study. J Clin Psychopharmacol 1985; 5: 10–16.PubMedCrossRefGoogle Scholar
  12. 12.
    Pope HG Jr, Hudson JI, Jonas JM, et al. Bulimia treated with imipramine: a placebo controlled double blind study. Am J Psychiatry 1983; 140: 555–558.Google Scholar
  13. 13.
    Hughes PL, Wells LA, Cunningham CJ, et al. Treating bulimia with desipramine. Arch Gen Psychiatry 1986; 43: 182–186.PubMedGoogle Scholar
  14. 14.
    Mitchell JE, Groat R. A placebo-controlled double-blind trial of amitriptyline and bulimia. J Clin Psychopharmacol 1984; 4: 186–193.PubMedCrossRefGoogle Scholar
  15. 15.
    Sabine EJ, Yonace A, Farrington AJ, et al. Bulimia nervosa: a placebo-controlled double-blind therapeutic trial of mianserin. Br J Pharmacol 1983; 15: 195–202.Google Scholar
  16. 16.
    Walsh BT, Stewart JW, Roose SP, et al. A double-blind trial of phenelzine in bulimia. J Psychiatr Res 1985; 19: 485–489.PubMedCrossRefGoogle Scholar
  17. 17.
    Kennedy SH, Piran N, Warsh JJ, et al. A trial of isocarboxazid in the treatment of bulimia. J Clin Psychopharmacol 1988; 8: 391–396.PubMedCrossRefGoogle Scholar
  18. 18.
    Coscina DV. Brain amines in hypothalamic obesity. In Vigersky RA (ed): Anorexia Nervosa. New York: Raven Press, 1977; 97–107.Google Scholar
  19. 19.
    Goldberg SC, Halmi KA, Eckert ED, et al. Cyproheptadine in anorexia nervosa. Br J Psychiatry 1979; 134: 67–70.PubMedCrossRefGoogle Scholar
  20. 20.
    Wurtman RJ, Wurtman JJ. Nutrients, neurotransmitter synthesis, and the control of food intake. Psychiatr Annu 1983: 13: 854–857.Google Scholar
  21. 21.
    Robinson PH, Checkley SA, Russell GFM. Suppression of eating by fenfluramine in patients with bulimia nervosa. Br J Psychiatry 1985; 146: 169–176.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Sidney H. Kennedy

There are no affiliations available

Personalised recommendations