Neurochemical and Behavioral Effects of Stress: A Rat Model of Depression
We have established a model for depression that has behavioral and neurochemical analogies to the human illness and also responds to antidepressant drugs. The model is based on effects of 2 h of restraint stress in the rat: (a) increased plasma corticosterone; (b) decreased locomotion and increased defecation on placement 24 h later in an open field; and (c) anorexia. Figure 1.1 shows typical results and that daily restraint leads to adaptation; behavior becomes normal.1
KeywordsDepression Attenuation Corticosteroid Cortisol Dexamethasone
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