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Neuropeptides and Stress pp 39–48Cite as

Stress-Related Behavioral Effects of Corticotropin-Releasing Factor

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Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HANS SELYE SYMP))

Abstract

In the late 1940’s and early 1950’s, Harris and others proposed a mechanism through which the endocrine stress response, manifested by pituitary-adrenal activation, could be “modified by changes in the external environment or in the central nervous system (psychological or emotional upsets)”1. This general concept, being explored at that time by several laboratories, was seminal in the development of the discipline of neuroendocrinology. It served as an impetus for the later work of Saffran and Schally2 and Guillemin and Rosenberg3, who demonstrated the ability of hypothalamic extracts to stimulate adrenocorticotropic hormone (ACTH) release from isolated pituitaries. These reports were the first of many from several laboratories over the next three decades. They served to characterize the hypothalamic releasing or inhibiting factors associated with pituitary hormones. Some of the resulting work was recognized in 1977 with the awarding of the Nobel Prize to Roger Guillemin and Andrew Schally.

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Authors
  1. Donald R. Britton
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Editor information

Editors and Affiliations

  1. Department of Medicine, Los Angeles School of Medicine, University of California, Los Angeles, California, 90073, USA

    Yvette Taché Ph.D. (Professor and Member) (Professor and Member)

  2. Brain Research Institute, Los Angeles, California, 90024, USA

    Yvette Taché Ph.D. (Professor and Member) & John E. Morley M.D. (Director, Professor and Member) (Professor and Member) &  (Director, Professor and Member)

  3. Geriatric Research, Education, and Clinical Center, Sepulveda Veterans Administration Medical Center, Sepulveda, California, 91343, USA

    John E. Morley M.D. (Director, Professor and Member) (Director, Professor and Member)

  4. Department of Medicine, Los Angeles, School of Medicine, University of California, Los Angeles, California, 90024, USA

    John E. Morley M.D. (Director, Professor and Member) (Director, Professor and Member)

  5. Autonomic Physiology Laboratory, Departments of Medicine and Surgery, San Diego Medical Center, University of California, San Diego, California, 92103, USA

    Marvin R. Brown M.D. (Professor) (Professor)

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© 1989 Springer-Verlag New York Inc.

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Britton, D.R. (1989). Stress-Related Behavioral Effects of Corticotropin-Releasing Factor. In: Taché, Y., Morley, J.E., Brown, M.R. (eds) Neuropeptides and Stress. Hans Selye Symposia on Neuroendocrinology and Stress. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3514-9_4

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  • DOI: https://doi.org/10.1007/978-1-4612-3514-9_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8135-1

  • Online ISBN: 978-1-4612-3514-9

  • eBook Packages: Springer Book Archive

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