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Opioid Receptors and Their Ligands

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Neuropeptides and Stress

Part of the book series: Hans Selye Symposia on Neuroendocrinology and Stress ((HANS SELYE SYMP))

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Abstract

Opioid receptors have been the focus of vigorous research efforts during the past decade. From the initial concept of a pharmacologic receptor complementary to morphine-like agents, a much more complex picture has emerged. A family of receptors, collectively known as opioid receptors, which interact with opioids, has been identified. The interest in these receptors stems not only from pharmacologic grounds but also from the need to characterize the physiologic importance of their endogenous ligands, the opioid peptides or endorphins. This latter aspect will be considered in the present chapter.

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References

  1. Martin WR, Eades CG, Thompson JA, et al. The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 1976;197:517–532.

    PubMed  CAS  Google Scholar 

  2. Atweh SF, Kuhar MJ. Distribution and significance of opioid receptors in the brain. Br Med Bull 1983;39:47–52.

    PubMed  CAS  Google Scholar 

  3. Tyers MB. A classification of opiate receptors that mediate antinociception in animals. Br J Pharmacol 1980;69:503–512.

    PubMed  CAS  Google Scholar 

  4. Upton N, Sewell RD, Spencer PS. Differentiation of potent mu- and kappa-opiate agonists using heat and pressure antinociceptive profiles and combined potency analysis. Eur J Pharmacol 1982;78:421–429.

    Article  PubMed  CAS  Google Scholar 

  5. Paterson SJ, Robson LE, Kosterlitz HW. Classification of opioid receptors. Br Med Bull 1983;39:31–36.

    PubMed  CAS  Google Scholar 

  6. Höllt V. Opioid peptide processing and receptor selectivity. Ann Rev Pharmacol Toxicol 1986;26:59–77.

    Article  Google Scholar 

  7. Nyberg F, Nylander I, Terenius L. Enkephalin-containing polypeptides in human cerebrospinal fluid. Brain Res 1986;371:278–286.

    Article  PubMed  CAS  Google Scholar 

  8. Gintzler AR. Endorphin-mediated increases in pain threshold during pregnancy. Science 1980;210:193–195.

    Article  PubMed  CAS  Google Scholar 

  9. Rust M, Eghert R, Gessler M, et al. Verminderte Schmerzempfindung während Schwangerschaft und Geburt. Arch Gynecol 1983;235:676–677.

    Google Scholar 

  10. Terenius L, Lyrenäs S, Lutsch H, et al. Opioid peptides at term pregnancy, in the early puerperium and in postpartum psychosis. In: Hypothalamic Dysfunction in Neuropsychiatric Disorders. Nerozzi D, Goodwin FK and Costa E, eds. New York: Raven Press, 1987: p. 201–209.

    Google Scholar 

  11. Lindström LH, Nyberg F, Terenius L, et al. CSF and plasma beta-casomor-phin-like opioid peptides in postpartum psychosis. Am J Psychiatry 1984; 141: 1059–1066.

    PubMed  Google Scholar 

  12. Henschen A, Lottspeich F, Brantl V, et al. Novel opioid peptides derived from casein (beta-casomorphins). II. Structure of active components from bovine casein peptone. Hoppe Seylers Z Physiol Chem 1979;360:1217–1224.

    PubMed  CAS  Google Scholar 

  13. Umbach M, Teschemacher H, Praetorius K, et al. Demonstration of a beta-casomorphin immunoreactive material in the plasma of newborn calves after milk intake. Regul Pept 1985;12:223–230.

    Article  PubMed  CAS  Google Scholar 

  14. Brantl V, Teschemacher H, Bläsig J, et al. Opioid activities of beta-casomorphins. Life Sci 1981;28:1903–1909.

    Article  PubMed  CAS  Google Scholar 

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© 1989 Springer-Verlag New York Inc.

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Terenius, L. (1989). Opioid Receptors and Their Ligands. In: Taché, Y., Morley, J.E., Brown, M.R. (eds) Neuropeptides and Stress. Hans Selye Symposia on Neuroendocrinology and Stress. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3514-9_20

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  • DOI: https://doi.org/10.1007/978-1-4612-3514-9_20

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8135-1

  • Online ISBN: 978-1-4612-3514-9

  • eBook Packages: Springer Book Archive

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