Role of Endogenous Corticotropin-Releasing Factor in Modulating the Pituitary Response to Stress
The exposure of rats to stressful stimuli results in increased adrenocorticotropic hormone (ACTH) secretion with decreased luteinizing hormone (LH) and growth hormone (GH) release. Since corticotropin-releasing factor (CRF) is also released during stress1, we investigated the possibility that changes in its endogenous levels might mediate the effect of stress on pituitary function.
KeywordsLuteinizing Hormone Growth Hormone Release Luteinizing Hormone Secretion Luteinizing Hormone Release Plasma Growth Hormone Level
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- 1.Plotsky PM, Vale WW. Hemorrhage-induced corticotropin-releasing factorlike immunoreactivity (CRF-LI) release into rat hypophysial portal blood. Endocrinology [Suppl] 1983;112:263 [Abstract #731].Google Scholar