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Malaria Sporozoite Vaccine Development: Recent Progress

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Progress in Vaccinology

Part of the book series: Progress in Vaccinology ((VACCINOLOGY,volume 2))

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Abstract

Control of falciparum malaria remains one of the world’s greatest health challenges. Global malaria eradication and control programs conducted over the past 50 years have been seriously hampered by the widespread development of drug resistance by the parasite and insecticide resistance by the mosquito vector. As a result, there is great interest in developing vaccines to prevent malaria, and there has been dramatic progress in the development of vaccines directed against the sporozoite stage of Plasmodium falciparum.

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References

  1. Ballou WR, Rothbard J, Wirtz RA, et al: Immunogenicity of synthetic peptides from circumsporozoite protein of Plasmodium falciparum. Science 1985; 228: 996–999.

    Article  PubMed  CAS  Google Scholar 

  2. Ballou WR, Hoffman SL, Sherwood JA, et al: Safety and efficacy of a re-combinant DNA Plasmodium falciparum sporozoite vaccine. Lancet 1987; 1: 1277–1281.

    Article  PubMed  CAS  Google Scholar 

  3. Chen DH, Tigelaar RE, Weinbaum FI: Immunity to sporozoite induced malaria infection in mice. I. The effect of immunization of T and B cell deficient mice. J Immunol 1977; 188: 1322–1327.

    Google Scholar 

  4. Chulay JD, Schneider I, Cosgriff TM, et al: Malaria transmitted to humans by mosquitoes infected from cultured Plasmodium falciparum. Am J Trop Med Hyg 1986; 35: 66–68.

    PubMed  CAS  Google Scholar 

  5. Clyde DF, McCarthy VC, Miller RM, Woodward WE: Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites. Am J Trop Med Hyg 1975; 24: 397–401.

    PubMed  CAS  Google Scholar 

  6. Dame JB, Williams JL, McCutchan TF, et al: Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science 1984; 225: 593–599.

    Article  PubMed  CAS  Google Scholar 

  7. Egan JE, Weber JL, Ballou WR, et al: Efficacy of murine malaria sporozoite vaccines: implications for human vaccine development. Science 1987,236:453– 456.

    Google Scholar 

  8. Good MF, Berzofsky JA, Maloy WL, et al: Genetic control of the immune response in mice to Plasmodium falciparum sporozoite vaccine: widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine. J Exp Med 1986; 164: 655–660.

    Article  PubMed  CAS  Google Scholar 

  9. Good MF, Maloy WL, Lunde MN, et al: Construction of synthetic immunogen: use of new T-helper epitope on malaria circumsporozoite protein. Science 1987; 235: 1059–1062.

    Article  PubMed  CAS  Google Scholar 

  10. Hockmeyer WT, Ballou WR, Young JF: Sporozoite malaria vaccines, in Chedid L, Hadden JW, Spreafico F, et al (eds): Advances in Pharmacology. Oxford, Pergamon Press, 1985, pp 357–361.

    Google Scholar 

  11. Hoffman SL, Cannon LT, Berzofsky JA: Plasmodium falciparum: a T cell epitope on sporozoite vaccine allows sporozoite boosting of immunity. Exp Parasitol 64: 64–70 (1987)

    Article  Google Scholar 

  12. Hoffman SL, Oster CN, Plowe CV, et al: Naturally acquired antibodies to sporozoites do not prevent malaria: Vaccine Development Implications Science 237: 639–642, 1987.

    Article  PubMed  CAS  Google Scholar 

  13. Nussenzweig R, Vanderberg J, Most H: Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. Milit Med 1969; 134: 1176–1182.

    CAS  Google Scholar 

  14. Potocnjak P, Yoshida N, Nussenzweig R, Nussensweig V: Monovalent frag-ments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malaria infection. J Exp Med 1980; 151: 1504–1513.

    Article  PubMed  CAS  Google Scholar 

  15. Rieckmann KH, Beaudoin RL, Cassells JS, Sell KW: Use of attenuated spo-rozoites in the immunization of human volunteers against falciparum malaria. Bull WHO 1979; 57 (suppl l): 261–265.

    PubMed  Google Scholar 

  16. Vanderberg J, Nussenzweig R, Most H: Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. V. In vito effects of immune serum on sporozoites. Milit Med 1969; 134: 1183–1190.

    CAS  Google Scholar 

  17. Verhave JP, Strickland GT, Jaffe HA, Ahmed A: Studies on the transfer of protective immunity with lymphoid cells from mice immune to malaria spo-rozoites. J Immunol 1978; 121: 1031–1033.

    PubMed  CAS  Google Scholar 

  18. Wirtz RA, Ballou WR, Schneider I, et al: Plasmodium falciparum: immuno- genicity of circumsporozoite protein constructs produced in Escherichia coli. Exp Parasitol 1987; 63: 166–172.

    Article  PubMed  CAS  Google Scholar 

  19. Young JF, Hockmeyer WT, Gross MT, et al: Expression of Plasmodium fal-ciparum circumsporozoite proteins in Escherichia coli for potential use in a human malaria vaccine. Science 1985; 228: 958–962.

    Article  PubMed  CAS  Google Scholar 

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© 1989 Springer-Verlag New York Inc.

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Ballou, W.R. (1989). Malaria Sporozoite Vaccine Development: Recent Progress. In: Talwar, G.P. (eds) Progress in Vaccinology. Progress in Vaccinology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3508-8_36

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  • DOI: https://doi.org/10.1007/978-1-4612-3508-8_36

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-96734-9

  • Online ISBN: 978-1-4612-3508-8

  • eBook Packages: Springer Book Archive

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