Abstract
Cholera is an important cause of morbidity and mortality in many devel-oping countries. Cholera is also the prototype for a large group of diarrheal diseases—the “enterotoxic enteropathies”—which may be responsible for roughly half of all diarrheal disease episodes in the world. These dis¬eases are caused by various bacteria that produce one or more toxins, which by upsetting normal fluid transport processes in the gut give rise to watery diarrhea.
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References
Black RE, Levine MM, Clements ML, et al: Protective efficacy in humans of killed whole-vibrio oral cholera vaccine with and without the B subunit of cholera toxin. Infect Immun 1987; 55: 1116–1120.
Clemens JD, Jertborn M, Sack DA, et al: Effect of neutralization of gastric acid on immune responses to an oral B subunit-killed whole-cell cholera vac¬cine. J Infect Dis 1986; 154: 175–178.
Clemens JD, Stanton BF, et al: B subunit-whole cell and whole cell-only oral vaccines against cholera: studies on reactogenicity and immunogenicity. J In-fect Dis 1987; 155: 79–85.
Clemens JD,Sack DA, Harris JR, et al: Field trial of oral cholera vaccines in Bangladesh Lancet 1986; 2: 124–127
Holmgren J, Svennerholm A-M, Lonnroth I, et al: Development of improved cholera vaccine based on subunit toxoid. Nature 1977; 269: 602–604.
Holmgren J: Actions of cholera toxin and the prevention and treatment of cholera. Nature 1981; 292: 413–417.
Holmgren J, Svennerholm A-M: Cholera and the immune response. Progr Allergy 1983; 33: 106–119.
Jertborn M, Svennerholm A-M, Holmgren J: Gut mucosal, salivary and serum antitoxic and antibacterial antibody responses in Swedes after oral immuni¬zation with B subunit-whole cell cholera vaccine. Int Arch Allergy Appl Im-munol 1984; 75: 38–43.
Levine MM, Kaper JB, Black RE, Clements ML: New knowledge on path-ogenesis of bacterial enteric infections as applied to vaccine development. Microbiol Rev 1983;47:510–550. 10.
Lycke N, Holmgren J: Long-term cholera antitoxin memory in the gut can be triggered to antibody formation associated with protection within hours of an oral challenge immunization. Scand J Immunol 1987; 25: 407–412.
Lycke N, Holmgren J: Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens. Immunology 1986; 59: 301–308.
Pierce NF: The role of antigen form and function in the primary and secondary intestinal immune responses to cholera toxin and toxoid in rats. J Exp Med 1978; 148: 195–206.
Svennerholm A-M, Holmgren J: Synergistic protective effect in rabbits of im¬munization with V. cholerae lipopolysaccharide and toxin/toxoid. Infect Immun 1976; 13: 735–740.
Svennerholm A-M, Sack DA, Holmgren J, Bardhan PK: Intestinal antibody responses after immunization with cholera B subunit. Lancet 1982; 1: 305–308.
Svennerholm A-M, Gothefors L, Sack DA, et al: Local and systemic antibody responses and immunological memory in humans after immunization with cholera B subunit by different routes. Bull WHO 1984; 62: 909–918.
Svennerholm A-M, Jertborn M, Gothefors L, et al: Mucosal antitoxic and antibacterial immunity after cholera disease and after immunization with a combined B subunit-whole cell vaccine. J Infect Dis 1984; 149: 884–893.
Tayot J-L, Holmgren J, Svennerholm L, et al: Receptor-specific large scale purification of cholera toxin on silica beads derivatized with lyso-GM,-gan- glioside. Eur J Biochem 1981; 113: 249–258.
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Holmgren, J., Clemens, J., Sack, D., Svennerholm, AM. (1989). Oral B Subunit-Whole Cell Vaccine Against Cholera: From Basic Research to Successful Field Trial. In: Talwar, G.P. (eds) Progress in Vaccinology. Progress in Vaccinology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3508-8_14
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DOI: https://doi.org/10.1007/978-1-4612-3508-8_14
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