Abstract
The outer membrane of the hepatitis B virus (HBV) consists of host lipids and the protein components’ major (p 25, gp 29), middle (gp 33, gp 36), and large (p 39, gp 41) envelope polypeptide (8). These proteins are encoded for by a large open reading frame of HBV DNA, which has three in-phase translation start codons (17). The major protein, encoded by the S gene, is the predominant structural constituent of noninfectious, 22-nm spherical or tubular particles and virions and expresses conformationally dependent hepatitis B surface antigen (HBsAg). The DNA sequence corresponding to the S gene and the region preceding the S gene (pre-S region) encode for the polypeptides larger than the S polypeptide. The “middle protein” represents S protein with an additional 55-amino-acid, conformation-independent fragment at the N-terminus encoded by the pre-S2 domain (10). The “large protein” is encoded for by the S, pre-S2, and pre-S1, domain; the latter is located either 108 or 119 codons upstream of the pre-S2 region. The large envelope polypeptide is preferentially expressed on HBV particles and filaments relative to 22-nm spheres (8).
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© 1989 Springer-Verlag New York Inc.
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Budkowska, A., Dubreuil, P., Pillot, J. (1989). Biologic Significance of Pre-S Antigen and Anti-Pre-S Antibodies in Hepatitis B Virus Infection. In: Talwar, G.P. (eds) Progress in Vaccinology. Progress in Vaccinology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3508-8_10
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DOI: https://doi.org/10.1007/978-1-4612-3508-8_10
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