Abstract
We will briefly discuss some general principles of cardiovascular regulation and question why neuropeptides merit special attention as regulators of the complex homeostatic system. We plan to touch on aspects of the evolution of peptides, their genetics, synthesis and processing. The renin-angiotensin system will serve as an example of a well characterized enzyme-peptide system, which occurs both as a hormonal and as a neuropeptidergic system clearly involved in cardiovascular control and hypertension
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References
Niall HD (1980) The evolution of peptide hormones. In: Endocrinology 1980, Proceedings of the Vlth International Congress of Endocrinology, Melbourne, Australia, Feb. 10–16, 1980, Australian Academy of Sciences, Amsterdam: Elsevier Press: pp. 13–18
Peach M (1977) Renin-angiotensin system: biochemistry and mechanism of action. Physiol Reviews 57: 313–370
Fischer-Ferraro C, Nahmod VE, Goldstein DJ, Finkielman S (1971) Angiotensin and renin in rat and dog brain. J Exp Med 133: 353–361
Ganten D, Minnich JL, Granger P, Hayduk K, Brecht HM, Barbeau A, Boucher R, Genest J (1971) Angiotensin-forming enzyme in brain tissue. Science 173: 64–65
Ganten D, Printz M, Phillips MI, Scholkens BA, eds 1982 The Renin Angiotensin System in the Brain. Experimental Brain Research (Suppl 4). New York: Springer
Dzau YJ (1984) Vascular renin-angiotensin: a possible autocrine or paracrine system in control of vascular function. J Cardiovasc Pharmacol 6: S377-S382
Dzau VJ, Ingelfinger J, Pratt RE, Ellison KE (1986) Identification of renin and angiotensinogen messenger RNA sequences in mouse and rat brains. Hypertension 8: 544–548
Ganten D, Lang RE, Lehmann E, Unger Th (1984) Brain angiotensin: on the way to becoming a well-studied neuropeptide system. Biochem Pharmacol 33: 3523–3528
Hirose S, Yokosawa H, Inagami T, Workman KJ (1980) Renin and prorenin in hog brain: ubiquitous distribution and high concentration in pituitary and pineal. Brain Res 191: 489–499
Suzuki F, Hellmann T, Murakami K, Ludwig G (1987) Expression of the genes for renin and angiotensinogen in tissues of rats. Naunyn-Schmiedebergs Arch Pathol 335: R66
Campbell DJ, Bouhnik J, Menard J, Corval P (1984) Identity of angiotensinogen precursors of rat brain and liver. Nature 308: 206–208
Nakanishi S, Ohkubo H, Nawa H, Kitamura N, Kageyama R, Ujihara M (1983) Angiotensinogen and kininogen: cloning and sequence analysis of the cD-NAS. Clin Exp Hyper A5(7/8): 997–1003
Lind RW, Swanson LW, Ganten D (1985) Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system, neuroendocrinology 40: 2–24
Lind RW, Swanson LW, Bruhn TO, Ganten D (1985) The distribution of angiotensin II-immunoreactive cells and fibers in the paraventriculo-hypophysial system of the rat. Brain Res 338: 81–89
Ganten D, Fluxe K, Phillips MI, Mann JFE, Ganten U (1978) The brain isorenin-angiotensin system: Biochemistry, localization and possible role in drinking and blood pressure regulation. In: Ganong WF, Martini L (eds) Frontiers in Neuroendocrinology, Vol. 5, New York: Raven Press: pp. 61–99
Rettig R, Lang RE, Rascher W, Unger Th, Ganten D (1982) Brain peptides and blood pressure regulation. Clin Sci 63: 269s-283s
Ganten D, Hermann K, Bayer C, Unger Th, Lang RE (1983) Angiotensin synthesis in the brain and increased turnover in hypertensive rats. Science 221: 869–871.
Schelling P, Meyer D, Loos HE, Speck G, Phillips MI, Johnson AK, Ganten D (1982) A micromethod for the measurement of renin in brain nuclei: its application in sponteously hypertensive rats. Neuropharmacology Rl: 455–463
Berecek KH, Okuno T, Nagahama S, Oparil S (1983) Altered vascular reactivity and baroreflex sensitivity induced by chronic central administration of Captopril in the spontaneously hypertensive rat. Hypertension 5: 689–700
Evered MD, Robinson MM, Richardson MA (1980) Captopril given intracerebroventricularly, subcutaneously or by gavage inhibits angiotensin converting enzyme activity in the rat brain. Eur J Pharmacol 68: 443–449
Mann JFE, Phillips MI, Dietz R, Haebara H, Ganten D (1978) Effects of central and peripheral angiotensin blockade in hypertensive rats. Am J Physiol 234: 629–637
McDonald W, Wickre C, Aumann S, Ban D, Moffit B (1980) The sustained antihypertensive effect of chronic cerebroventricular infusion of angiotesnin antagonist in spontaneously hypertensive rats. Endocrinology 107: 1305–1308
Unger Th, Kaufmann-Buhler I, Scholkens B, Ganten D (1981) Brain converting enzyme inhibition: a possible mechanism for the antihypertensive action of Captopril in spontaneously hypertensive rats. Eur J Pharmacol 70: 467–478
Unger Th, Ganten D, Lang RE (1983) Pharmacology of converting enzyme inhibitors: new aspect. Clin Exp Hypertension A5(7/8): 1333–1354
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Ganten, D., Lindpaintner, K., Lang, R.E., Unger, T. (1989). Neuroendocrine Aspects of Cardiovascular Control: The Brain Renin-Angiotensin System. In: Wass, J.A.H., Scanlon, M.F. (eds) Neuroendocrine Perspectives. Neuroendocrine Perspectives, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3478-4_8
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DOI: https://doi.org/10.1007/978-1-4612-3478-4_8
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