Abstract
Neither the pathogenesis nor the treatment of pituitary tumors in man is yet well understood. The mechanisms controlling both hormone release and gene transcription in the rat pituitary are becoming increasingly better understood; however, knowledge concerning hormonal control of the human pituitary gland is still largely limited to studies of hormone release from cultured tissue (1,2), and there are very few studies of the regulation of human pituitary gene transcription. In this paper, we report preliminary data from studies of two unusual and aggressive human tumors grown in short-term monolayer cell culture. We have applied the techniques of DNA/RNA hybridization analysis to study the control of cytoplasmic messenger RNA levels in order to give some index of pretranslational stages of hormone synthesis.
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© 1989 Springer-Verlag New York Inc.
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Davis, J.R.E., Wilson, E.M., Sheppard, M.C. (1989). Human Pituitary Tumors in Cell Culture: Modulation of Prolactin and Growth Hormone Messenger RNA Levels in Vitro. In: Wass, J.A.H., Scanlon, M.F. (eds) Neuroendocrine Perspectives. Neuroendocrine Perspectives, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3478-4_27
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DOI: https://doi.org/10.1007/978-1-4612-3478-4_27
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-8117-7
Online ISBN: 978-1-4612-3478-4
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