HLA Humoral Allosensitization

Clinical Significance of Humoral Allosensitization of HLA Antigens
  • René J. Duquesnoy


HLA specific humoral sensitization presents a significant problem to patients considered for organ transplantation or platelet transfusion therapy. This alloimmunization can result from previous exposure to HLA antigens through blood transfusion, transplantation and pregnancy. Alloantibodies are usually determined by testing patient serum in complement-dependent lymphocytotoxicity assays against an HLA typed cell panel and the percentage of panel reactive antibody (PRA) indicates the degree of humoral sensitization of patients. Moreover, crossmatch assays of patient sera are generally necessary for the selection of appropriate donors.


Platelet Transfusion Liver Allograft Hyperacute Rejection Panel Reactive Antibody Humoral Sensitization 
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© Springer-Verlag New York Inc. 1990

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  • René J. Duquesnoy

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