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Gastrointestinal Peptide Binding and Function in the Brain: Emphasis on Peptide YY

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Neuroendocrine Perspectives

Part of the book series: Neuroendocrine Perspectives ((NEUROENDOCRINE,volume 8))

Abstract

In the last decade, a large number of gastrointestinal peptides have been found in the brain, some of which fulfill criteria established for neurotransmitters. Several neurons containing a classical transmitter, including catecholamine and acetylcholine, also contain these peptide transmitters (1). Neuropeptides thus act both dependently with and independently from, for example, monoamines (2), either presynaptically through modulation of the release of monoamines, postsynaptically through modulation of the monbaminergic effector response, or through a direct receptor-receptor interaction (3). These factors affect various body functions, including cardiovascular, respiratory, gastrointestinal, endocrine and central nervous system (CNS) functions. Neuropeptide research thus has become one of the most rapidly growing areas of neuroscience.

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Authors
  1. Akio Inui
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  2. Shigeaki Baba
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Editors and Affiliations

  1. Department of Pharmacology, University of Milan, School of Medicine, 20129, Milan, Italy

    Eugenio E. Müller

  2. Department of Internal Medicine, University of Virginia, School of Medicine, 22908, Charlottesville, Virginia, USA

    Robert M. MacLeod

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Inui, A., Baba, S. (1990). Gastrointestinal Peptide Binding and Function in the Brain: Emphasis on Peptide YY. In: Müller, E.E., MacLeod, R.M. (eds) Neuroendocrine Perspectives. Neuroendocrine Perspectives, vol 8. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3446-3_5

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