CNS Depressants: Barbiturates, Barbiturate-like Drugs, Meprobamate, Chloral Hydrate, Paraldehyde

  • H. Thomas MilhornJr.


In addition to alcohol, drugs that depress the central nervous system include the barbiturates, barbiturate-like drugs, meprobamate, chloral hydrate, paraldehyde, and benzodiazepines. These drugs are mainly used to calm and relax patients (sedatives) or to induce sleep in them (hynotics). They are collectively known as sedative-hynotics. The benzodiazepines are discussed in Chapter 10.


Chloral Hydrate Barbituric Acid Delirium Tremens Abstinence Syndrome Severe Respiratory Depression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    O’Brien, R., and S. Cohen. Barbiturates. In The Encyclopedia of Drug Abuse. Facts on File, New York, 1984, pp. 35–38.Google Scholar
  2. 2.
    Cohen, S. The barbiturates: Has their time gone? In The Substance Abuse Problems: Volume One. Haworth Press, New York, 1981, pp. 119–124.Google Scholar
  3. 3.
    Wilford, B. B.(Ed.). Major drugs of abuse. In Drug Abuse: A Guide for the Primary Care Physician. American Medical Association, Chicago 1981, pp. 21–84.Google Scholar
  4. 4.
    Harvey, S. Hypnotics and sedatives. In Goodman and Gilman’s The Pharmacological Basis of Therapeutics. Ed. by A. G. Gilman, L. S. Goodman, T. W. Rail, and F. Murad, Macmillan, New York, 1985, pp. 339–369.Google Scholar
  5. 5.
    Trevor, A. J., and W. L. Way. Sedative-hypnotics. In Basic and Clinical Pharmacology. Ed. by B. G. Katzung. Appleton and Lange, Norwalk, Connecticut, 1987, pp. 241–253.Google Scholar
  6. 6.
    Schonberg, S. K.(Ed.). Specific drugs. In Substance Abuse: A Guide for Health Professionals. American Academy of Pediatrics, Elk Grove Village, Illinois, 1988, pp. 115–182.Google Scholar
  7. 7.
    Smith, D. E., and D. R. Wesson. A new method for treatment of barbiturate dependence. Journal of the American Medical Association, 213:294–295, 1970.PubMedCrossRefGoogle Scholar
  8. 8.
    Wilford, B. B. (Ed.). Sub-acute care. In Review Course Syllabus. American Medical Society on Alcohol and Other Drug Dependencies, New York, 1987, pp. 189–218.Google Scholar
  9. 9.
    Kulberg, A. Substance abuse: Clinical identification and management. Pediatric Toxicology, 33:325–361, 1986.Google Scholar
  10. 10.
    Conces, D. J., D. L. Kreipke, and R. D. Tarver. Pulmonary edema associated with intravenous ethchlorvynol. American Journal of Emergency Medicine, 4:549–551, 1986.PubMedCrossRefGoogle Scholar
  11. 11.
    Gwilt, P. R., M. D. Pankaskie, R. Zustiak, and D. R. Shoenthal. Pharmacokinetics of methyprylon following a single oral dose. Journal of Pharmaceutical Science, 74:1001–1003, 1985.CrossRefGoogle Scholar
  12. 12.
    Hasson, E. Treatment of meprobamate overdose with repeated oral doses of activated charcoal. Annals of Emergency Medicine, 15:73–76, 1986.CrossRefGoogle Scholar
  13. 13.
    Bertino, J. S., Jr., and M. D. Reed. Barbiturate and nonbarbiturate sedative hypnotic intoxication in children. Pediatric Clinics of North America, 33:703–722, 1986.Google Scholar
  14. 14.
    Ananthakopan, S. Severe lactic acidosis following paraldehyde administration. British Journal of Psychiatry, 149:650–651, 1986.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • H. Thomas MilhornJr.
    • 1
  1. 1.Department of Family MedicineUniversity of Mississippi Medical CenterMississippiUSA

Personalised recommendations