Mechanisms of Xanthine Actions in Models of Asthma

  • R. E. Howell
  • R. F. Gaudette
  • M. C. Raynor
  • A. T. Warner
  • W. T. Muehsam
  • J. A. Schenden
  • J. Perumattam
  • R. N. Hiner
  • W. J. Kinnier
Conference paper

Abstract

Theophylline has long been one of the most effective and frequently used drugs for the treatment of asthma. Recently another xanthine, enprofylline, has been found useful for the treatment of asthma (Pauwels, et al, 1985). Unfortunately, the mechanism of action of xanthines in the lung remains unclear. Inhibition of cyclic nucleotide phosphodiesterase (PDE) activity was originally considered the mechanism of theophylline’s anti-asthmatic effects (Piafsky and Ogilvie, 1975). However, it has been claimed that at therapeutic plasma levels theophylline does not appreciably inhibit PDE activity and thus PDE inhibition cannot account for the clinical effects of theophylline (Persson, et al, 1986).

Keywords

Adenosine Serotonin Histamine Theophylline Purine 

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References

  1. Barnes, P.J., 1987, Am. Rev. Resp. Dis. 135:526–531.Google Scholar
  2. Barnes, P.J., Chung, K.F. and Page, C.P., 1988, J. Allergy Clin. Immunol. 81:919–934.PubMedCrossRefGoogle Scholar
  3. Bruns, R.F., Lu, G.H. and Pugsley, T.A., 1986, Mol. Pharmacol. 29:331–346.PubMedGoogle Scholar
  4. Clemo, H.F., Bourassa, A., Linden J. and Belardinelli, L, 1987, J. Pharmacol. Exp. Ther. 242:478–484.PubMedGoogle Scholar
  5. Choi, O.H., Shamin, M.T., Padgett, W.L. and Daly, J.W., 1988, Life Sci. 43:387–398.PubMedCrossRefGoogle Scholar
  6. Fredholm, B.B., 1980, Eur. J. Respir. Dis. (Suppl. 109) 61:29–36.Google Scholar
  7. Fredholm, B.B., Bergman, B., Fastbon, J. and Jonzon, B., 1985, in Anti-Asthma Xanthines and Adenosine. K-E. Andersson and C.G.A. Persson (eds), 291–308, Excerpta Medica, Amsterdam.Google Scholar
  8. Hughes, P.J., Holgate, S.T. and Church, M.K., 1984, Biochem. Pharmacol. 33:3847–3852.PubMedCrossRefGoogle Scholar
  9. Jancar, S., Theriault, P., Provencal, B., Cloutier, S. and Sirois, P., 1988, Can. J. Physiol. Pharmacol. 66:1187–1191.PubMedCrossRefGoogle Scholar
  10. Lefort, J., Rotilio, D. and Vargaftig, B.B., 1984, Br. J. Pharmacol. 82:525–531.Google Scholar
  11. Noronha-Blob, L., Marshall, R.P., Kinnier, W.J. and U’Prichard, D.C., 1986, Life Sci. 39:1059–1067.PubMedCrossRefGoogle Scholar
  12. Ogawa, K., Takagi, K. and Satake, T., 1989, Br. J. Pharmacol. 97:542–546.PubMedGoogle Scholar
  13. Pauwels, R., 1987, Chest 92:325–375.Google Scholar
  14. Pauwels, R., Van Renterghem, D., Van Der Straeten, M., Johannesson, N. and Persson, C.G.A., 1985, J. Allergy Clin. Immunol. 76:583–590.PubMedCrossRefGoogle Scholar
  15. Peachell, P.T., Columbo, M., Kagey — Sobotka, A., Lichtenstein, L.M. and Marone, G., 1988, Am. Rev. Resp. Dis. 138:1143–1151.PubMedGoogle Scholar
  16. Persson, C.G.A., Andersson, K-E. and Kjellin, G., 1986, Life Sei. 38:1057–1072.PubMedCrossRefGoogle Scholar
  17. Piafsky, K.M. and Ogilvie, R.I, 1975, N.E. J. Med. 292:1218–1222.CrossRefGoogle Scholar
  18. Polosa, R., Holgate, S.T. and Church, M.K., 1989, Pulmonary Pharmacol. 2:21–26.CrossRefGoogle Scholar
  19. Polson, J.B, Krzanowski, J.J. and Szentivanyi, A., 1982, Biochem. Pharmacol. 31:3403–3406.PubMedCrossRefGoogle Scholar
  20. Schwabe, U., Ukena, D. and Lohse, M.J., 1985, N-S. Arch. Pharmacol. 330:212–221.CrossRefGoogle Scholar
  21. Scotini, E., Carpenedo, F. and Fassina, G., 1983, Pharmacol. Res. Commun. 15:131–143.PubMedCrossRefGoogle Scholar
  22. Smellie, F.W., Davis, C.W, Daly, J.W. and Wells, J.M., 1979, Life Sei. 24:2475–2482.PubMedCrossRefGoogle Scholar
  23. Ukena, D., Schirren, C.G., Klotz, K.N. and Schwabe, U., 1985, N-S. Arch. Pharmacol. 331:89–95.CrossRefGoogle Scholar
  24. Williams, M., Braunwalder, A. and Erickson, T.J., 1986, N-S. Arch. Pharmacol. 332:179–183.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • R. E. Howell
  • R. F. Gaudette
  • M. C. Raynor
  • A. T. Warner
  • W. T. Muehsam
  • J. A. Schenden
  • J. Perumattam
  • R. N. Hiner
  • W. J. Kinnier

There are no affiliations available

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