Effects of Adenosine on Mast Cells

  • M. J. Lohse
  • K.-N. Klotz
  • K. Maurer
  • I. Ott
  • U. Schwabe
Conference paper

Abstract

Stimulation of mast cells with appropriate antigen results in the rapid release of a large number of mediators of allergy from the cells. The cells possess cell surface receptors for the Fc portion of IgE which serve to transmit the signal of binding of an antigen by the IgE molecule to the interior of the cell. Since monovalent antigens are not capable of inducing mast cell secretion it is believed that crosslinking of IgE molecules by di-or polyvalent antigens represent the appropriate stimuli (Foreman 1980). These stimuli ultimately result in the release of two groups of mediators of allergy: preformed mediators, and secondary or newly formed mediators. Preformed mediators are stored in the mast cell granules and become released upon fusion of the granules with the plasma membrane; they include histamine, serotonin, chemotactic factors, lysosomal enzymes and heparin. Secondary mediators are synthesized only after stimulation of mast cells and then immediately released; they include prostaglandin D2, leukotrienes and platelet activating factor (Siraganian 1983).

Keywords

Heparin Adenosine Serotonin Histamine Theophylline 

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References

  1. Almers, W., Neher, E., 1985, The Ca signal from fura-2 loaded mast cellsdepends strongly on the method of dye-loading. FEBS Lett. 192, 13–18.PubMedCrossRefGoogle Scholar
  2. Church, M.K., Holgate, S.T., Hughes, P.J., 1983, Adenosine inhibits and potentiates IgE-dependent histamine release from human basophils by an A2-receptor mediated mechanism. Br. J. Pharmacol. 80, 719–726.PubMedGoogle Scholar
  3. Enerback, L., 1986, Mast cell heterogeneity: the evolution of the concept of a specific mucosal mast cell. In: Mast Cell Differentiation and heterogeneity, ed. Befus, A.D. et al., Raven Press, New York, pp.1–26.Google Scholar
  4. Foreman, J., 1980, Receptor-secretion coupling in mast cells. Trends Pharmacol. Sci. 1, 460–462.CrossRefGoogle Scholar
  5. Hughes, P.J., Holgate, S.T., Church, M.K., 1984, Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism. Biochem. Pharmacol. 33, 3847–3852.PubMedCrossRefGoogle Scholar
  6. Hughes, P.J., Church, M.K., 1986, Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells. Agents and Actions 18, 81–84.PubMedCrossRefGoogle Scholar
  7. Leoutsakos, A., Pearce, F.L., 1986, The effect of adenosine and its analogues on cyclic AMP changes and histamine secretion from rat peritoneal mast cells stimulated by various ligands. Biochem. Pharmacol. 35, 1373–1379.PubMedCrossRefGoogle Scholar
  8. Lohse, M.J., Maurer, K., Gensheimer, H.-P., Schwabe, U., 1987, Dual effects of adenosine on rat peritoneal mast cells. Naunyn-Schmiedeberg’s Arch. Pharmacol. 335, 555–560.CrossRefGoogle Scholar
  9. Lohse, M.J., Klotz, K.-N., Salzer, M.J., Schwabe, U., 1988, Adenosine regulates the Ca++ sensitivity of mast cell mediator release. Proc. Natl. Acad. Sci. USA 85, 8875–8879.PubMedCrossRefGoogle Scholar
  10. Lohse, M.J., Maurer, K., Klotz, K.-N., Schwabe, U., 1989, Synergistic effects of calcium-mobilizing agents and adenosine on histamine release from rat peritoneal mast cells. Br. J. Pharmacol. (in press).Google Scholar
  11. Marone, G., Findlay, S.R., Lichtenstein, L.M., 1979, Adenosine receptor on human basophils: Modulation of histamine release. J. Immunol. 123, 1473–1477.PubMedGoogle Scholar
  12. Marquardt, D.L., Parker, C.W., Sullivan, T.J., 1978, Potentiation of mast cell mediator release by adenosine. J. Immunol. 120, 871–878.PubMedGoogle Scholar
  13. Marquardt, D.L., Gruber, H.E., Wasserman, S.I., 1984, Adenosine release from stimulated mast cells. Proc. Natl. Acad. Sci. USA 81, 6192–6196.PubMedCrossRefGoogle Scholar
  14. Marquardt, D.L., Walker, L.L., 1988, Alteration of mast cell responsiveness to adenosine by pertussis toxin. Biochem. Pharmacol. 37, 4019–4025.PubMedCrossRefGoogle Scholar
  15. Marquardt, D.L., Walker, L.L., 1989, Pretreatment with phorbol esters abrogates mast cell adenosine responsiveness. J. Immunol. 142, 1268–1273.PubMedGoogle Scholar
  16. Peachell, P.T., Columbo, M., Kagey-Sobotka, A., Lichtenstein, L.M., Marone, G., 1988, Adenosine potentiates mediator release from human lung mast cells. Am. Rev. Resp. Dis. 138, 1143–1151.PubMedGoogle Scholar
  17. Penner, R., 1988, Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells. Proc. Natl. Acad. Sci. USA 85, 9856–9860.PubMedCrossRefGoogle Scholar
  18. Siraganian, R.P., 1983, Histamine-secretion from mast-cells and basophils. Trends Pharmacol. Sci. 4, 432–437.CrossRefGoogle Scholar
  19. Vardey, C.J., Skidmore, I.F., 1985, Characterization of the adenosine receptor responsible for the enhancement of mediator release from rat mast cells. In: Purines: Pharmacology and physiological roles, ed. Stone, T.W., VCH Verlagsgesellschaft, Weinheim, p 175.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • M. J. Lohse
  • K.-N. Klotz
  • K. Maurer
  • I. Ott
  • U. Schwabe

There are no affiliations available

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