Effects of Adenosine on Mast Cells
Stimulation of mast cells with appropriate antigen results in the rapid release of a large number of mediators of allergy from the cells. The cells possess cell surface receptors for the Fc portion of IgE which serve to transmit the signal of binding of an antigen by the IgE molecule to the interior of the cell. Since monovalent antigens are not capable of inducing mast cell secretion it is believed that crosslinking of IgE molecules by di-or polyvalent antigens represent the appropriate stimuli (Foreman 1980). These stimuli ultimately result in the release of two groups of mediators of allergy: preformed mediators, and secondary or newly formed mediators. Preformed mediators are stored in the mast cell granules and become released upon fusion of the granules with the plasma membrane; they include histamine, serotonin, chemotactic factors, lysosomal enzymes and heparin. Secondary mediators are synthesized only after stimulation of mast cells and then immediately released; they include prostaglandin D2, leukotrienes and platelet activating factor (Siraganian 1983).
KeywordsHeparin Adenosine Serotonin Histamine Theophylline
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