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Intracellular and Extracellular Metabolism of Adenosine and Adenine Nucleotides

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Abstract

ATP is not solely the major intracellular biochemical energy currency, directly regulating the activities of a wide variety of proteins and other molecules which are substrates for phosphorylation. It also serves as the precursor for an important intracellular second messenger molecule, cyclic AMP, which in turn regulates the activities of a subset of proteins via cyclic AMP-dependent protein kinases, as discussed elsewhere in this volume.

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References

  • Berne, R.M., 1980, The role of adenosine in the regulation of coronary blood flow, Circ. Res. 47:807–813.

    PubMed  CAS  Google Scholar 

  • Born, G.V.R., and Kratzer. M.A.A., 1984, Source and concentration of extracellular adenosine triphosphate during haemostasis in rats, rabbits and man, J. Physiol. (Lond.), 354:419–429.

    CAS  Google Scholar 

  • Burnstock, G., and Kennedy, C., 1986, Is there a basis for distinguishing two types of P2-purinoceptor?, Gen. Pharmacol. 16:433–440.

    Google Scholar 

  • Coade, S.B., and Pearson, J.D., 1989, Metabolism of adenine nucleotides in human blood, Circ. Res. 65: (in press).

    Google Scholar 

  • Fleetwood, G., and Gordon, J.L., 1987, Purinoceptors in the rat heart, Br. J. Pharmacol. 90:219–227.

    PubMed  CAS  Google Scholar 

  • Fleetwood, G., et al., 1989, Kinetics of adenine nucleotide catabolism in the coronary circulation, Am. J. Physiol. 256:H1565-H1572.

    PubMed  CAS  Google Scholar 

  • Gordon, E.L., Pearson, J.D., and Slakey, L.L., 1986, The hydrolysis of extracellular adenine nucleotides by cultured endothelial cells from pig aorta, J. Biol. Chem. 261:15496–15504.

    PubMed  CAS  Google Scholar 

  • Gordon, E.L., et al., 1989, The hydrolysis of extracellular adenine nucleotides by arterial smooth muscle cells, J. Biol. Chem. 264: in press.

    Google Scholar 

  • Hellewell, P.G., and Pearson, J.D., 1987, Adenine nucleotides and pulmonary endothelium, In: Pulmonary Endothelium in Health and Disease, ed. Ryan U; New York, Dekker, pp.327–348.

    Google Scholar 

  • Lin, S.-H., and Guidotti, G., 1989, Cloning and expression of a cDNA coding for a rat liver plasma membrane ecto-ATPase, J. Biol. Chem. 264:14408–14414.

    PubMed  CAS  Google Scholar 

  • Low, M.G., and Finean, J.B., 1978, Specific release of plasma membrane enzymes by a phosphatidylinositol-specific phospholipase C, Biochim. Biophys. Acta 508:565–570.

    Article  PubMed  CAS  Google Scholar 

  • Milner, P., et al., 1989, Endothelial cells cultured from human umbilical vein can release ATP, Substance P and acetylcholine, Experientia (submitted).

    Google Scholar 

  • Newby, A.C., 1984, Adenosine and the concept of ’retaliatory metabolites’, Trends Biochem. Sci. 9:42–44.

    Article  CAS  Google Scholar 

  • Newby, A.C., 1988, The pigeon heart 5’-nucleotidase responsible for ischaemia-induced adenosine formation, Biochem. J. 253:123–130.

    PubMed  CAS  Google Scholar 

  • Olsson, R.A., and Pearson, J.D., 1989, Cardiovascular purinoceptors, Physiol. Rev. (in press).

    Google Scholar 

  • Pearson, J.D., 1987, Nucleotide metabolism, In: Mammalian Ectoenzymes, eds. Kenny AJ & Turner AJ; Amsterdam, Elsevier, pp.139–167.

    Google Scholar 

  • Pearson, J.D., and Gordon, J.L., 1979, Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides, Nature 281:384–386.

    Article  PubMed  CAS  Google Scholar 

  • Pearson, J.D., and Gordon, J.L., 1989, P2-purinoceptors in the blood vessel wall, Biochem. Pharmacol. (in press).

    Google Scholar 

  • Pearson, J.D., et al., 1978, Uptake and metabolism of adenosine in pig aortic endothelial and smooth muscle cells in culture. Biochem. J. 170:265–271.

    PubMed  CAS  Google Scholar 

  • Pearson, J.D., Carleton, J.S., and Gordon, J.L., 1980, Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth muscle cells in culture, Biochem. J. 190:421–429.

    PubMed  CAS  Google Scholar 

  • Ryan, J.W., and Ryan, U.S., 1984, Endothelial surface enzymes and the dynamic proessing of plasma substrates, Int. Rev. Exp. Path. 26:1–43.

    PubMed  CAS  Google Scholar 

  • Truong, V.L., Collinson, A.R., and Lowenstein, J.M., 1988, 5’-Nucleotidases in rat heart. Evidence for the occurrence of two soluble enzymes with different substrate specificities, Biochem. J. 253:117–121.

    PubMed  CAS  Google Scholar 

  • Van Belle, H., Goossens, F., and Wynants, J., 1987, Formation and release of purine catabolites during hypoperfusion, anoxia, and ischemia, Am. J. Physiol. 252-.H886-H893.

    PubMed  Google Scholar 

  • White, T.D., 1988, Role of adenine compounds in autonomic neurotransmission, Pharmacol. Ther. 38:129–168.

    Article  PubMed  CAS  Google Scholar 

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© 1990 Springer-Verlag New York Inc.

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Pearson, D., Slakey, L.L. (1990). Intracellular and Extracellular Metabolism of Adenosine and Adenine Nucleotides. In: Jacobson, K.A., Daly, J.W., Manganiello, V. (eds) Purines in Cellular Signaling. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3400-5_2

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  • DOI: https://doi.org/10.1007/978-1-4612-3400-5_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7996-9

  • Online ISBN: 978-1-4612-3400-5

  • eBook Packages: Springer Book Archive

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