Ionic Currents in Carotid Body Type I Cells and the Effects of Hypoxia and NaCN

  • J. Hescheler
  • M. A. Delpiano
Conference paper

Summary

Whole-cell currents of type I cells were characterized using the patch-clamp technique. At least four types of currents could be separated: 1) outward rectifying currents, which were sensitive to Cs+ and tetraethylammonium (TEA); 2) Ca2+-dependent outward currents (Co2+ sensitive); 3) TTXinsensitive slowly inactivating inward currents blocked by organic and inorganic Ca2+-channel blockers; 4) Na+ currents were observed also but not analyzed. Decreasing Po2 in the bath did not affect the Ca2+-inward currents but reduced the amplitude of the outward rectifying K+ current.

Keywords

Dopamine MgCl Cyanide Catecholamine HEPES 

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Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • J. Hescheler
  • M. A. Delpiano

There are no affiliations available

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