Vasopressinergic Influence in the Cat Carotid Body
In 1969, Pearse (1) predicted that the carotid body type 1 cells, as part of the APUD series of cells, would contain a low molecular weight polypeptide. These cells are now known to contain several peptides (2) but have not been tested for the presence of vasopressin (AVP). AVP-like immunoreactivity has been demonstrated in a number of peripheral tissues, including sympathetic ganglia and the adrenal medulla. These two tissues share a common embryological origin with the carotid body and exogenous AVP has been shown to affect neurotransmission in sympathetic ganglia (3) and catecholamine secretion by adrenal medullary cells (4). It is noteworthy that sympathetic ganglia possess oxygen chemosensitivity (5).
KeywordsTyrosine Bromide Tungsten Polypeptide Arginine
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