Vasopressinergic Influence in the Cat Carotid Body

  • A. Bradford
  • R. G. O’Regan
Conference paper

Abstract

In 1969, Pearse (1) predicted that the carotid body type 1 cells, as part of the APUD series of cells, would contain a low molecular weight polypeptide. These cells are now known to contain several peptides (2) but have not been tested for the presence of vasopressin (AVP). AVP-like immunoreactivity has been demonstrated in a number of peripheral tissues, including sympathetic ganglia and the adrenal medulla. These two tissues share a common embryological origin with the carotid body and exogenous AVP has been shown to affect neurotransmission in sympathetic ganglia (3) and catecholamine secretion by adrenal medullary cells (4). It is noteworthy that sympathetic ganglia possess oxygen chemosensitivity (5).

Keywords

Tyrosine Bromide Tungsten Polypeptide Arginine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Pearse AGE (1969). The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem 17: 303–313.PubMedCrossRefGoogle Scholar
  2. 2.
    Wharton J, Polak JM, Pearse AGE, McGregor GP, Bryant MG, Bloom SR, Emson PC, Bisgard GE, Will JA (1980). Enkephalin-, VIP- and substance P-like immunoreactivity in the carotid body. Nature 284: 269–271.PubMedCrossRefGoogle Scholar
  3. 3.
    Kiray M, Maillard M, Dreifuss JJ, Dolivo M (1985). Neurohypophyseal peptides depress cholinergie transmission in a mammalian sympathetic ganglion. Neurosci Lett 62: 89–95.CrossRefGoogle Scholar
  4. 4.
    Nussey SS, Prysor-Jones RA, Taylor A, Ang VTY, Jenkins JS (1987). Arginine vasopressin and oxytocin in the bovine adrenal gland. J Endocr 115: 141–149.PubMedCrossRefGoogle Scholar
  5. 5.
    Matsumoto A, Mokashi A, Lahiri S (1987). Ganglioglomerular nerves respond to moderate hypoxia independent of peripheral chemoreceptors in the cat. J Autonomic Nery Syst 19: 219–228.CrossRefGoogle Scholar
  6. 6.
    Honig A, Landgraf R, Ledderhos C, Quies W (1987). Plasma vasopressin levels in healthy young men in response to stimulation of the peripheral arterial chemoreceptors by almitrine bimesylate. Biomed Biochim Acta 46: 1043–1049.PubMedGoogle Scholar
  7. 7.
    O’Regan RG, Majcherczyk A (1983). Control of peripheral chemoreceptors by efferent nerves. In: Acker H, O’Regan RG (Eds). Physiology of the Peripheral Arterial Chemoreceptors, Amsterdam, Elsevier Biomedical Press, pp. 257–298.Google Scholar
  8. 8.
    Neil E, O’Regan RG (1971). The effects of electrical stimulation of the distal end of the cut sinus and aortic nerves on peripheral arterial chemoreceptor activity in the cat. J Physiol (Lond) 215: 15–32.Google Scholar
  9. 9.
    Manning M, Sawyer WH (1984). Design and uses of selective agonistic and antagonistic analogs of the neuropeptides oxytocin and vasopressin. Trends Neurosci 7: 6–9.CrossRefGoogle Scholar
  10. 10.
    Jard S, Gaillard RC, Guillon G, Marie J, Schoenenberg P, Muller AF, Manning M, Sawyer WH (1986). Vasopressin antagonists allow demonstration of a novel type of vasopressin receptor in the rat adenohypophysis. Mol Pharmacol 30: 171–177.PubMedGoogle Scholar
  11. 11.
    Aisenbrey GA, Handelman WA, Arnold P, Manning M, Schrier RW (1981). Vascular effects of arginine vasopressin during fluid deprivation in the rat. J Clin Invest 67: 961–968.PubMedCrossRefGoogle Scholar
  12. 12.
    Schmid PG, Abboud FM, Wendling MG, Ramberg ES, Mark AL, Heistad DD, Eckstein JW (1974). Regional vascular effects of vasopressin: plasma levels and circulatory responses. Am J Physiol 227: 998–1004.PubMedGoogle Scholar
  13. 13.
    Liard JF, Deriaz O, Schelling P, Thibonnier M (1982). Cardiac output distribution during vasopressin infusion or dehydration in conscious dogs. Am J Physiol 243: H663 - H669.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • A. Bradford
  • R. G. O’Regan

There are no affiliations available

Personalised recommendations