Abstract
Despite extensive efforts by the medical community, preterm delivery remains a major cause of perinatal morbidity and mortality in the United States. The present 8% rate of preterm delivery has been constant for much of this century. Despite the introduction of new pharmacologic agents to arrest preterm labor, protocols to detect patients susceptible to preterm labor, and devices to monitor uterine activity, no decrease in the rate of preterm delivery has occurred.
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References
Fedrick J, Anderson AB. Factors associated with spontaneous pre-term birth. Br J Obstet Gynaecol 1976;83:342–350.
Funderburk SJ, Guthrie E, Meldrum D. Suboptimal pregnancy outcome among women with prior abortions and premature births. Am J Obstet Gynecol. 1976; 126: 55–60.
Carr-Hill RA, Hall MH. The repitition of spontaneous preterm labour. Br L Obstet Gynaecol. 1985;92:921–928.
Keirse MJ, Rush RW, Anderson AB, et al. Risk of pre-term delivery in patients with previous preterm delivery and/or abortion. Br J Obstet Gynaecol. 1978;85:81–85.
Heinonen PK, Saarikoski S, Pystynen P. Reproductive performance of women with uterine anomalies. Acta Ostet Gynecol Scand. 1982;61:157–162.
Aharoni A, Reiter A, Golan D, et al. Patterns of growth of uterine leiomyomas during pregnancy. A prospective longitudinal study. Br J Obstet Gynaecol. 1988;95: 510–513.
Papiernik E. Proposals for a programmed prevention policy of preterm birth. Clin Obstet Gynecol. 1984;27:614–635.
Hoffman HJ, Bakketeig LS. Risk factors associated with the occurrence of preterm birth. Clin Obstet Gynecol. 1984;27:539–552.
Greenberg RS. The impact of prenatal care in different social groups. Am J Obstet Gynecol. 1983;145:797–801.
Graham GG. Poverty, hunger, malnutrition, prematurity, and infant mortality in the United States. Pediatrics. 1985;75:117–125.
Damstetter C, Shain RN, Gibbs RS. Pregnancy outcome in three racial/ethnic groups in San Antonio. Presented at meeting of Society of Perinatal Obstetricians; February 1989; New Orleans, La. Abstract 369.
Buescher PA, Smith C, Holliday JL, et al. Source of prenatal care and infant birth weight: the case of a North Carolina county. Am J Obstet Gynecol. 1987; 156:204–210.
Meyer MB, Tonascia JA. Maternal smoking, pregnancy complications, and perinatal mortality. Am J Obstet Gynecol. 1977;128:494–502.
Rush D, Stein Z, Süsser M. A randomized controlled trial of prenatal nutritional supplementation in New York City. Pediatrics. 1980;65:683–697.
Murphy JF, Dauncey M, Newcombe R, et al. Employment in pregnancy: prevalence, maternal characteristics, perinatal outcome. Lancet. 1984;2:1163–1166.
Grunebaum A, Minkoff J, Blake D. Pregnancy among obstetricians: a comparison of births before, during, and after residency. Am J Obstet Gynecol. 1987;157:79–83.
Newton RW, Hunt LP. Psychosocial stress in pregnancy and its relation to low birth weight. Br Med J. 1984;288:1191–1194.
Anderson AB, Turnbull AC. Relationship between length of gestation and cervical dilatation, uterine contractility and other factors during pregnancy. Am J Obstet Gynecol. 1969;105:1207–1214.
Brustman LE, Raptoulis M, Langer O, et al. Changes in the pattern of uterine contractility in relationship to coitus during pregnancies at low and high risk for preterm labor. Obstet Gynecol. 1989;73:166–168.
Daikoku WH, Kaltreider DF, Khouzami VA, et al. Premature rupture of membranes and spontaneous preterm labor: maternal endometritis risks. Obstet Gynecol. 1982; 59:13–20.
Miller JM, Pupkin MJ, Hill GB. Bacterial colonization of amniotic fluid from intact fetal membranes. Am J Obstet Gynecol. 1980;136:796–804.
Duff P, Kopelman JN. Subclinical intra-amniotic infection in asymptomatic patients with refractory preterm labor. Obstet Gynecol. 1987;69:756–759.
Bejar R, Curbelo V, Davis C, et al. Premature labor, II: bacterial sources of phospholipase. Obstet Gynecol. 1981;57:479–482.
Minkoff H, Grunebaum AN, Schwarz RH, et al. Risk factors for prematurity and premature rupture of membranes: a prospective study of the vaginal flora in pregnancy. Am J Obstet Gynecol. 1984;150:965–972.
Morales WH, Angel JL, O’Brien WF, et al. A randomized study of antibiotic therapy in idiopathic preterm labor. Obstet Gynecol. 1988;72:829–833.
McGregor JA, French JI, Reller LB, et al. Adjunctive erythromycin treatment for idiopathic preterm labor: results of a randomized, double-blinded, placebo-controlled trial. Am J Obstet Gynecol. 1986;154:98–103.
Creasy RK, Gummer BA, Liggins GC. System for predicting spontaneous preterm birth. Obstet Gynecol. 1980;55:692–695.
Fedrick J. Antenatal identification of women at high risk of spontaneous pre-term birth. Br J Obstet Gynecol. 1976;83:351–354.
Cousins LM, Hobel CJ, Chang RJ, et al. Serum progesterone and estradiol -17 Beta levels in premature and term labor. Am J Obstet Gynecol. 1977;127:612–615.
Block BS, Liggins, Creasy RK. Preterm delivery is not predicted by serial plasma estradiol or progesterone concentration measurements. Am J Obstet Gynecol. 1984; 150:716–722.
Coulam CB, Wasmoen T, Creasy RK, et al. Major basic protein as a predictor of preterm labor: a preliminary report. Am J Obstet Gynecol. 1987;156:790–796.
Romero R, Mazor M, Oyarzun E, et al. Interleukin-1 and the initiation of preterm labor. Presented at meeting of Society of Perinatal Obstetricians; February 1989; New Orleans, La. Abstract 28.
Branch DW, Scott JR, Kochenour NK et al. Obstetric complication associated with the lupus anticoagulant. N Engl J Med. 1985;313:1322–1326.
Lübbe WF, Liggins GC. Lupus anticoagulant and pregnancy. Am J Obstet Gynecol. 1985;153:322–327.
Brock DJ, Barron L, Jelen P, et al. Maternal serum-alpha-fetoprotein measurements as an early indicator of low birth-weight. Lancet. 1977;1:267–268.
Wald N, Cuckle H, Stirrat GM, et al. Maternal serum-alpha-fetoprotein and low birth-weight. Lancet. 1977;1:268–269.
Herron MA, Katz M, Creasy RK. Evaluation of a preterm birth prevention program: preliminary report. Obstet Gynecol. 1982;59:452–456.
Main DM, Gabbe SG, Richardson D, et al. Can preterm deliveries be prevented? Am J Obstet Gynecol. 1985;151:892–898.
Papiernik E, Bouyer J, Yaffe K, et al. Women’s acceptance of a preterm birth prevention program. Am J Obstet Gynecol. 1986;155:939–946.
Meis PJ, Ernest JM, Moore JM, et al. Regional program for prevention of premature birth in northwestern North Carolina. Am J Obstet Gynecol. 1987;157:550–556.
Zlatnik FJ. The applicability of labor inhibition to the problem of prematurity. Am J Obstet Gynecol. 1972;113:704–706.
Papiernik E, Bouyer J, Collin D, et al. Precocious cervical ripening and preterm labor. Obstet Gynecol. 1986;67:238–242.
Neilson JP, Verkuyl AA, Crowther CA, et al. Preterm labor in twin pregnancies: prediction by cervical assessment. Obstet Gynecol. 1988;72:719–723.
Leveno KJ, Cox K, Roark ML. Cervical dilatation and prematurity revisited. Obstet Gynecol. 1986;68:434–435.
Weekes AR, Flynn MJ. Engagement of the fetal head in Primigravidae and its relationship to duration of gestation and time of onset of labour. Br J Obstet Gynecol. 1975;82:7–11.
Holbrook RH, Falcon J, Herron M, et al. Evaluation of the weekly cervical examination in a preterm birth prevention program. Am J Perinatal. 1987;4:240–244.
Floyd W. Cervical dilatation in the mid-trimester of pregnancy. Obstet Gynecol. 1961;18:380–381.
Baker RC, Goldenberg RL, Davis RO, et al. Warning symptoms and cervical exam changes in women at risk for preterm delivery. Presented at meeting of Society of Perinatal Obstetricians; February 1989; New Orleans, La. Abstract 377.
Suranyi S, Szomolya M. The clinical prediction of premature labour by self-observation of uterine contractility and external tocography. J Perinat Med. 1980;9: 140–141.
Newman RB, Gill PJ, Wittreich P, et al. Maternal perception of prelabor uterine activity. Obstet Gynecol. 1986;68:765–769.
Katz M, Gill PJ, Newman RB. Detection of preterm labor by ambulatory monitoring of uterine activity: a preliminary report. Obstet Gynecol. 1986;68:773–778.
Morrison JC, Martin JN, Martin RW, et al. Prevention of preterm birth by ambulatory assessment of uterine activity: a randomized study. Am J Obstet Gynecol. 1987;156:536–543.
Katz M, Gill PJ, Newman RB. Detection of preterm labor by ambulatory monitoring of uterine activity for the management of oral tocolysis. Am J Obstet Gynecol. 1986; 154:1253–1256.
Aubry RH, Pennington JC. Identification and evaluation of high-risk pregnancy: the perinatal concept. Clin Obstet Gynecol. 1973;16:3–27.
Bell R. The prediction of preterm labour by recording spontaneous antenatal uterine activity. Br J Obstet Gynaecol. 1983;90:884–887.
Katz M, Newman RB, Gill PJ. Assessment of uterine activity in ambulatory patients at high risk of preterm labor and delivery. Am J Obstet Gynecol. 1986;154:44–47.
Main DM, Katz M, Chin G, et al. Intermittent weekly contraction monitoring to predict preterm labor in low-risk women: a blinded study. Obstet Gynecol. 1988; 72:757–760.
Morrison J, Martin R, Gookin K, et al. Comparison of uterine activity versus symptomatology in the detection of preterm labor. Presented at meeting of Society of Perinatal Obstetricians; February 1989; New Orleans, La. Abstract 385.
Newman RB, Richmond GS, Winston YE, et al. Antepartum uterine activity characteristics differentiating true from threatened preterm labor. Presented at meeting of Society of Perinatal Obstetricians; February 1989; New Orleans, La. Abstract 29.
Iams JD, Johnson FF, O’Shaughnessy RW, et al. A prospective random trial of home uterine activity monitoring in pregnancies at increased risk of preterm labor. Am J Obstet Gynecol. 1987;157:638–643.
Korenbrot CC, Aalto LH, Laros RK. The cost effectiveness of stopping preterm labor with beta-adrenergic treatment. N Engl J Med. 1984;310:691–696.
Castle BM, Turnbull AC. The presence of absence of fetal breathing movements predicts the outcome of preterm labour. Lancet. 1983;2:471–472.
Boylan P, O’Donovan P, Owens OJ. Fetal breathing movements and the diagnosis of labor: a prospective analysis of 100 cases. Obstet Gynecol. 1985;66:517–520.
Besinger RE, Comptom AA, Hayashi RH. The presence of absence of fetal breathing movements as a predictor of outcome in preterm labor. Am J Obstet Gynecol. 1987;157:753–757.
Creasy RK, Katz M. Basic research and clinical experience with beta-adrenergic tocolytics in the United States. In: Fuchs F, Stubblefield PG, eds. Preterm Birth: Causes, Prevention and Management. New York, NY: Macmillan; 1984:150–170.
Gonik B, Creasy RK. Preterm labor: its diagnosis and management. Am J Obstet Gynecol. 1986;154:3–8.
Berg G, Andersson RG, Ryden G. Beta-adrenergic receptors in human myometrium during pregnancy: changes in the number of receptors after beta-mimetic treatment. Am J Obstet Gynecol. 1985;151:392–396.
Barden TP, Peter JB, Merkatz IR. Ritodrine hydrochloride: a betamimetic agent for use in preterm labor. Obstet Gynecol. 1980;56:1–6.
Bieniarz J, Motew M, Scommenga A. Uterine and cardiovascular effects of ritodrine in premature labor. Obstet Gynecol. 1972;40:65–73.
Bieniarz J, Ivankovich A, Scommenga A. Cardiac output during ritodrine treatment in premature labor. Am J Obstet Gynecol. 1974;118:910–920.
Fuchs F. Prevention of prematurity. Am J Obstet Gynecol. 1976;126:809–820.
Spellacy WN, Cruz AC, Birk SA, et al. Treatment of premature labor with ritodrine: a randomized controlled study. Obstet Gynecol. 1979;54:220–223.
Larsen JF, Eldon K, Lange AP, et al. Ritrodrine in the treatment of preterm labor: second Danish multicenter study. Obstet Gynecol. 1986;67:607–613.
Merkatz IR, Peter JB, Barden TP. Ritodrine hydrochloride: a betamimetic agent for use in preterm labor. Obstet Gynecol. 1980;56:7–12.
Ingemarsson I. Effect of terbutaline on premature labor. Am J Obstet Gynecol. 1976;125:520–524.
Wallace RL, Caldwell DL, Ansbacher R, et al. Inhibition of premature labor by terbutaline. Am J Obstet Gynecol. 1978;51:387–392.
Creasy RK, Golbus MS, Laros RK, et al. Oral ritodrine maintenance in the treatment of preterm labor. Am J Obstet Gynecol. 1980;137:212–219.
Brown SM, Tejani NA. Terbutaline sulfate in the prevention of recurrence of premature labor. Obstet Gynecol. 1981;57:22–25.
Stubblefield PG, Heyl PS. Treatment of premature labor with subcutaneous terbutaline. Obstet Gynecol. 1982;59:457–462.
Lam F, Gill P, Smith M, et al. Use of the subcutaneous terbutaline pump for long-term tocolysis. Obstet Gynecol. 1988;72:810–813.
Wagner JM, Morton MJ, Johnson KA, et al. Terbutaline and maternal cardiac function. JAMA. 1981;246:2697–2701.
Benedetti TJ. Maternal complications of parenteral beta-sympathomimetic therapy for preterm labor. Am J Obstet Gynecol. 1983; 145:1–6.
Caritis SN, Lin LS, Toig G, et al. Pharmacodynamics of ritodrine in pregnant women during preterm labor. Am J Obstet Gynecol. 1983;147:752–759.
Katz M, Robertson PA, Creasy RK. Cardiovascular complications associated with terbutaline treatment for preterm labor. Am J Obstet Gynecol. 1981;139:605–608.
Goyert G, Bhatia R, Schubert C, et al. Does intravenous ritodrine therapy cause capillary endothelial damage? Am J Perinatal. 1987;4:331–333.
Philipsen T, Eriksen PS, Lynggard F. Pulmonary edema following ritodrine-saline infusion in premature labor. Obstet Gynecol. 1981;58:304–308.
Young DC, Toofanian A, Leveno KJ. Potassium and glucose concentrations without treatment during ritodrine tocolysis. Am J Obstet Gynecol. 1983;145:105–106.
Spellacy WN, Cruz AC, Buhi WC, et al. The acute effects of ritrodrine infusion on maternal metabolism: measurements of levels of glucose, insulin, glucagon, triglycerides, cholesterol, placental lactogen, and chorionic gonadotropin. Am J Obstet Gynecol. 1978;131:637–642.
Kauppila A, Tuimala R, Ylikorkala O, et al. Effects of ritodrine and isoxsuprine with the without dexamethasone during late pregnancy. Obstet Gynecol. 1978;51:288–292.
Main DM, Main EK, Strong SE, et al. The effect of oral ritrodrine therapy on glucose tolerance in pregnancy. Am J Obstet Gynecol. 1985;152:1031–1033.
Main EK, Main DM, Gabbe SG. Chronic oral terbutaline tocolytic therapy is associated with maternal glucose intolerance. Am J Obstet Gynecol. 1987; 157: 644–647.
Cruikshank DP, Pitkin RM, Reynolds WA, et al. Effects of magnesium sulfate treatment on perinatal calcium metabolism. Am J Obstet Gynecol. 1979;134:243–249.
Elliott JP. Magnesium sulfate as a tocolytic agent. Am J Obstet Gynecol. 1983; 147: 277–284.
Spisso KR, Harbert GM, Thiagarajah S. The use of magnesium sulfate as the primary tocolytic agent to prevent premature delivery. Am J Obstet Gynecol. 1982; 142:840–845.
Wilkins IA, Lynch L, Mehalek KE, et al. Efficacy and side effects of magnesium sulfate and ritodrine as tocolytic agents. Am J Obstet Gynecol. 1988;159:685–689.
Miller JM, Keane MW, Horger EO. A comparison of magnesium sulfate and terbutaline for the arrest of premature labor. J Reprod Med. 1982;27:348–351.
Beall MH, Edgar BW, Paul RH, et al. A comparison of ritodrine, terbutaline, and magnesium sulfate for the suppression of preterm labor. Am J Obstet Gynecol. 1985; 153:854–859.
Hollander DI, Nagey DA, Pupkin MJ. Magnesium sulfate and ritrodrine hydrochloride: a randomized comparison. Am J Obstet Gynecol. 1987;156:631–637.
Martin RW, Gaddy DK, Martin JN, et al. Tocolysis with oral magnesium. Am J Obstet Gynecol. 1987;156:433–434.
Lipsitz PJ. The clinical and biochemical effects of excess magnesium in the newborn. Pediatrics. 1971;47:501–509.
Green KW, Key TC, Wen R, et al. The effects of maternally administered magnesium sulfate on the neonate. Am J Obstet Gynecol. 1983;146:29–33.
Niebyl JR, Blake DA, White RD, et al. The inhibition of premature labor with indomethacin. Am J Obstet Gynecol. 1980;136:1014–1019.
Dudley DK, Hardie MJ. Fetal and neonatal effects of indomethacin used as a tocolytic agent. Am J Obstet Gynecol. 1985;151:181–184.
Niebyl JR, Witter FR. Neonatal outcome after indomethacin treatment for preterm labor. Am J Obstet Gynecol. 1986;155:747–749.
Moise KJ, Huhta JC, Sharif DS, et al. Indomethacin in the treatment of premature labor. N Engl J Med. 1988;319:327–331.
Cabrol D, Landesman R, Muller J, Et al. Treatment of polyhydramnios with prostaglandin synthetase inhibitor (indomethacin). Am J Obstet Gynecol. 1987; 157: 422–426.
Bond A, Druzin M, Edersheim T, et al. Chronic indomethacin administration and oligohydramnios. Presented at meeting of Society of Perinatal Obstetricians; February 1989; New Orleans, La. Abstract 352.
Read MD, Wellby DE. The use of a calcium antagonist (nifedipine) to suppress preterm labour. Br J Obstet Gynecol. 1986;93:933–937
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Treadwell, M.C., Eden, R. (1990). Preterm Labor: Prediction, Prevention, and Treatment. In: Rathi, M. (eds) Current Perinatology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3380-0_4
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