Lipoproteins and Pathogenesis of Atherosclerosis
Let us start with the assumption that we all agree, along with the NIH Consensus Panel on Lowering Blood Cholesterol (1), that hypercholesterolemia in some way contributes importantly to the progress of human atherosclerosis. The question that remains to be answered is: How? Most investigators have assumed that hypercholesterolemia does its damage as a consequence of a high rate of delivery of cholesterol and other lipids into the artery wall. This is really just a restatement of the Virchow lipid infiltration hypothesis put forward about 100 years ago. However, even a casual look at a complicated human atherosclerotic lesion makes it clear that much more goes on than just the deposition of lipids. There are crucially important elements of cellular proliferation and accumulation of connective tissue matrix materials that contribute significantly to the ultimate stenosis of the vessel.
KeywordsCholesterol Migration Toxicity Peroxi Foam
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