Abstract
Whereas atherosclerosis of the coronary arteries frequently is manifested as chronic stable angina, many patients rapidly evolve to acute ischemic syndromes. The mechanisms by which this conversion from a stable state to clinically unstable coronary artery disease usually occurs because of severe coronary stenosis by occlusive plaque (1). For the past several years the contribution of coronary thrombosis to acute ischemic syndromes and the interaction of coronary thrombus with underlying plaque has been debated (2). Importantly, the fate of the occlusive thrombus in patients has remained unclear. Many authors have concluded that whether or not thrombosis spontaneously resolves, there is some incorporation into the arterial wall which contributes to the underlying plaque itself (3–7). This phenomenon may correlate with waxing and waning of ischemic symptoms.
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© 1990 Springer-Verlag New York Inc.
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DeWood, M.A., Leimgruber, P.P., Stifter, W.F. (1990). Observations Regarding the Thrombotic Process in Human Subjects. In: Glagov, S., Newman, W.P., Schaffer, S.A. (eds) Pathobiology of the Human Atherosclerotic Plaque. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3326-8_25
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DOI: https://doi.org/10.1007/978-1-4612-3326-8_25
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