Cell Births and Cell Deaths in the Human Atherosclerotic Plaque as Evaluated from Human Studies

  • W. A. Thomas
  • D. N. Kim
Conference paper

Abstract

At the outset it must be said that there are very little quantitative data on cell births and deaths in human atherogenesis. Therefore my presentation must be of necessity largely speculative.

Keywords

Cholesterol Corn Aspirin Paraffin Thymidine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Dock W (1946) The predilection of atherosclerosis for the coronary arteries. JAMA 131:875–878Google Scholar
  2. 2.
    Schornagel HE (1956) Intimal thickening in the coronary arteries in infants. Arch Pathol 62:427–432Google Scholar
  3. 3.
    Moon HD (1957) Coronary arteries in fetuses, infants, and juveniles. Circulation 16:263–267PubMedGoogle Scholar
  4. 4.
    Stehbens WE (1960) Focal intimal proliferation in the cerebral arteries. Am J Path 36:289–301PubMedGoogle Scholar
  5. 5.
    Neufeld HN, Wagenvoort CA, and Edwards JE (1962) Coronary arteries in fetuses, infants, juveniles, and young adults. Lab Invest 11:837–844PubMedGoogle Scholar
  6. 6.
    Geer JC, McGill HC, Robertson WB, and Strong JP (1968) Histologic characteristics of coronary artery fatty streaks. Lab Invest 18:565–570PubMedGoogle Scholar
  7. 7.
    Getz GS, Vesselinovitch D, and Wissler RW (1969) A dynamic pathology of atherosclerosis. Am J Med 46:657–673CrossRefGoogle Scholar
  8. 8.
    Haust MD (1971) The morphogenesis and fate of potential and early atherosclerotic lesions in man. Hum Path 2:1–29PubMedCrossRefGoogle Scholar
  9. 9.
    Stary HC and Strong JP (1976) Coronary artery fine structure in Rhesus monkeys: Nonatherosclerotic intimal-thickening. Prim Med 9:321–358Google Scholar
  10. 10.
    Stary HC (1976) Coronary artery fine structure in Rhesus monkeys: The early atherosclerotic lesion and its progression. Prim Med 9:359–395Google Scholar
  11. 11.
    Velican C and Velican D (1976) Intimal thickening in developing coronary arteries and its relevance to atherosclerotic involvement. Atherosclerosis 23:345–355CrossRefGoogle Scholar
  12. 12.
    Thomas WA, Reiner JM, Florentin RA, and Scott RF (1979) Population dynamics of arterial cells during atherogenesis. VIII. Separation of the roles of injury and growth stimulation in early aortic atherogenesis in swine originating in preexisting intimal smooth cell masses. Exptl Mol Pathol 31:124–144CrossRefGoogle Scholar
  13. 13.
    Velican D and Velican C (1979) Study of fibrous plaques occurring in the coronary arteries of children. Atherosclerosis 33:201–215PubMedCrossRefGoogle Scholar
  14. 14.
    Scott RF, Thomas WA, Lee WM, Reiner JM, and Florentin RA (1979) Distribution of intimal smooth muscle cell masses and their relationship to early atherosclerosis in abdominal aortas of young swine. Atherosclerosis 34:291–301PubMedCrossRefGoogle Scholar
  15. 15.
    Thomas WA, Kim DN, Lee KT, Reiner JM, and Schmee J (1983) Population dynamics of arterial cells during atherogenesis. Part 13 Mitogenic and cytotoxic effects of a hyperlipidemic (HL) diet on cells in advanced lesions in the abdominal aortas of swine fed an HL diet for 270–345 days. Exptl Mol Pathol 39:257–270CrossRefGoogle Scholar
  16. 16.
    Velican C and Velican D (1983) Progression of coronary atherosclerosis from adolescence to mature adults. Atherosclerosis 47:131–144PubMedCrossRefGoogle Scholar
  17. 17.
    Kim DN, Lee KT, Schmee J and Thomas WA (1983) Antiproliferative effect of pyridinolcarbomate and of aspirin in the early stages of atherogenesis in swine. Atherosclerosis 48:1–13PubMedCrossRefGoogle Scholar
  18. 18.
    Stary HC (1983) Structure and ultrastructure of the coronary artery intima in children and young adults up to age 29. In: Atherosclerosis VI. Proceedings of the Sixth International Symposium. Schettler FG <Emphasis FontCategory=“NonProportional”> et al</Emphasis> (eds) Springer-Verlag, Berlin/Heidelberg/New York, pp 82–86Google Scholar
  19. 19.
    Grottum P, Svindland A and Walloe L (1983) Localization of atherosclerotic lesions in the bifurcation of the main left coronary artery. Atherosclerosis 47:55–62PubMedCrossRefGoogle Scholar
  20. 20.
    Kim DN, Schmee J, Lee KT, and Thomas WA (1984) Hypoatherogenic effect of dietary corn oil exceeds hypocholesterolemic effect in swine. Atherosclerosis 52:101–113PubMedCrossRefGoogle Scholar
  21. 21.
    Kim DN, Lee KT, Schmee J, Thomas WA (1984) Quantification of intimal cell masses and atherosclerotic lesions in coronary arteries of control and hyperlipidemic swine. Atherosclerosis 52:115–122PubMedCrossRefGoogle Scholar
  22. 22.
    Kim DN, Schmee J, Lee KT, and Thomas WA (1985) Intimal cell masses in the abdominal aortas of swine fed a low-fat, low-cholesterol diet for up to twelve years of age. Atherosclerosis 55:151–159PubMedCrossRefGoogle Scholar
  23. 23.
    Kim DN, Schmee J, Lee KT, and Thomas WA (1985) Intimal cell mass (ICM) -derived atherosclerotic lesions in the abdominal aorta of hyperlipidemic (HL) swine. I. Cell of origin, cell divisions and cell losses in first 90 days on HL diet. Atherosclerosis 56:169–188PubMedCrossRefGoogle Scholar
  24. 24.
    Imai H, Connell CE, Lee KT, Kim DN, and Thomas WA (1985) Differential counts by electron microscopy of cell types 17. in normal intimal cell masses in swine abdominal aortas. Exptl Mol Pathol 42:377–388CrossRefGoogle Scholar
  25. 25.
    Cornhill JF, Barrett WA, Herderick EE, Mahley RW, and Fry DL (1985) Topographic study of sudanophilic lesions in cholesterol-fed minipigs by image analysis. Arteriosclerosis 5:415–426PubMedCrossRefGoogle Scholar
  26. 26.
    Imai H and Thomas WA (1968) Cerebral atherosclerosis in swine: Role of necrosis in progression of diet-induced lesions from proliferative to atheromatous stage. Exptl Mol Pathol 8:330–357CrossRefGoogle Scholar
  27. 27.
    Imai H, Lee SK, Pastori SJ, and Thomas WA (1970) Degeneration of arterial smooth muscle cells: Ultra-structural study of smooth muscle cell death in control and cholesterol-fed animals. Virchows Arch Abt A Path Anat 350:183–204CrossRefGoogle Scholar
  28. 28.
    Imai H, Werthessen NT, Taylor CB, and Lee KT (1976) Angiotoxicity and arteriosclerosis due to contaminants of USP-grade cholesterol. Arch Pathol Lab Med 100: 565–572PubMedGoogle Scholar
  29. 29.
    Scott RF, Florentin RA, Daoud AS, Morrison ES, Jones RM, and Hutt MSR (1966) Coronary arteries of children and young adults. A comparison of lipids and anatomic features in New Yorkers and East Africans. Exptl Mol Pathol 5:12–42CrossRefGoogle Scholar
  30. 30.
    Daoud A, Jarmolych J, Zumbo O, Fani K and Florentin R (1964) “Preatheroma” phase of coronary atherosclerosis in man. Exptl Mol Pathol 3:475–484CrossRefGoogle Scholar
  31. 31.
    Benditt EP and Benditt JM (1973) Evidence for a monoclonal origin of human atherosclerotic plaques. Proc Natl Acad Sci USA 70:1753–1756PubMedCrossRefGoogle Scholar
  32. 32.
    Pearson TA, Wang A, Solez K, and Hiptinstall RH (1975) Clonal characteristics of fibrous plaques and fatty streaks from human aortas. Am J Pathol 81:379–388PubMedGoogle Scholar
  33. 33.
    Pearson TA, Dillman JM, Solez K, and Hiptinstall RH (1978) Clonal markers in the study of origin and growth of human atherosclerotic lesions. Circ Res 43:10–18PubMedGoogle Scholar
  34. 34.
    Pearson TA, Dillman JM, Solez K, Hiptinstall RH (1978) Clonal characteristics in layers of human atherosclerotic plaques. Am J Pathol 93:93–102PubMedGoogle Scholar
  35. 35.
    Thomas WA, Reiner JM, Janakidevi K, Florentin RA, and Lee KT (1979) Population dynamics of arterial cells during atherogenesis. X. Study of monotypism in atherosclerotic lesions of black women heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD). Exptl Mol Pathol 31:367–386CrossRefGoogle Scholar
  36. 36.
    Lee KT, Thomas WA, Janakidevi K, Droms M, Reiner JM and Borg KY (1981) Mosaicism in female hybrid hares heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD). I. General properties of a hybrid hare model with special reference to atherogenesis. Exptl Mol Pathol 34:191–201CrossRefGoogle Scholar
  37. 37.
    Janakidevi K, Lee KT, Thomas WA, Reiner JM, and Murray CD (1981) Mosaicism in female hybrid hares heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD). II. Changes in the ratios of G-6-PD types in skin fibroblast carried through multiple passages. Exptl Mol Pathol 34:202–208CrossRefGoogle Scholar
  38. 38.
    Murray CD, Lee Kt, Thomas WA, Reiner JM, and Janakidevi K (1981) Mosaicism in female hybrid hares heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD). III. Changes in the ratios of G-6-PD types in skin fibroblast exposed to 25-hydroxy cholesterol. Exptl Mol Pathol 34:209–215CrossRefGoogle Scholar
  39. 39.
    Thomas WA, and Kim DN (1983) Biology of disease: Atherosclerosis as a hyperplastic and/or neoplastic process. Lab Invest 48:245–255PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • W. A. Thomas
  • D. N. Kim

There are no affiliations available

Personalised recommendations