NMR Spectroscopy of Tumors

  • J. D. Glickson
  • J. P. Wehrle
  • S. S. Rajan
  • S. J. Li
  • R. G. Steen

Abstract

Magnetic resonance imaging is widely employed in the clinical detection of cancer. Discrimination of tumors from surrounding normal tissues is based on differences in relaxation times, which are usually longer for tumors, and distortion of surrounding anatomy. While imaging has proven very sensitive, particularly for central nervous system tumors, it has limited specificity, making discrimination of tumors from a number of nonmalignant pathologies difficult. Efforts to improve diagnostic efficacy, via tumor-specific antibodies tagged with relaxation-enhancing agents, appear intrinsically limited by the relatively large quantities of antibodies required to produce a detectable enhancement (Lauffer 1987). These limitations have heightened interest in NMR spectroscopy, a technique that provides metabolic information potentially relevant to diagnosis and therapy.

Keywords

Ischemia Oncol Dexamethasone Neurol HUll 

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Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • J. D. Glickson
  • J. P. Wehrle
  • S. S. Rajan
  • S. J. Li
  • R. G. Steen

There are no affiliations available

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