Biosynthesis and Fibrillogenesis
FN is a large and complex glycoprotein with extensive intramolecular and intermolecular disulfide bonding (Chapter 6). It is both a secreted protein and a fibrillar matrix protein (Chapter 4) and in the latter situation, interacts with other macromolecules. The production and secretion of FN and the formation of FN-rich matrices are, therefore, complex problems of some intrinsic interest. In addition, these processes are all potentially sites of regulation and/or perturbation of FN structure and function, e.g., during normal cellular growth and differentiation (Chapters 10 and 11), oncogenic transformation (Chapter 12), or inflammatory processes (Chapter 14). In this chapter I will discuss the processes of synthesis, posttranslational modification, secretion and fibrillogenesis of FN, and some aspects of the regulation of these processes in cultured cells.
KeywordsHyaluronic Acid Rough Endoplasmic Reticulum Human Skin Fibroblast Extracellular Matrice High Molecular Weight Complex
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