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Diagnosis and Treatment of Osteoporosis

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Endocrine Function and Aging

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Abstract

Osteoporosis is a condition in which the mass of bone tissue is very low, and the risk of fracture is therefore considerable. A low bone mass per se is not symptomatic. It is the fractures that cause signs and symptoms. The quality of bone as a tissue may be impaired in osteoporosis, in part through the accumulation of unrepaired trabecular microfractures and in part through aging-associated changes in tissue composition.1–5 Fractures of the spine, wrist, and hip are most common.

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References

  1. Atkinson PJ. Variation in trabecular structure of vertebrae with age. Calcif Tissue Res 1967;1:24–32.

    Article  CAS  PubMed  Google Scholar 

  2. Vernon-Roberts B, Pirie CJ. Healing trabecular microfractures in the bodies of lumbar vertebrae. Ann Rheum Dis 1973;32:406–412.

    Article  CAS  PubMed  Google Scholar 

  3. Parfitt AM. Age-related structural changes in trabecular and cortical bone. Cellular mechanisms and biomechanical consequences. Calcif Tissue Int 1984;36:123–128.

    Article  Google Scholar 

  4. Kent GN, Dodds RA, Bitensky L, et al. Changes in crystal size and orientation of acidic glycosaminoglycans at the fracture site in fractured necks of femur. J Bone Joint Surg 1983;65B: 189–194.

    Google Scholar 

  5. Ferris BD, Klenerman L, Dodds RA, et al. Altered organization of non-collagenous bone matrix in osteoporosis. Bone 1987;8:285–288.

    Article  CAS  PubMed  Google Scholar 

  6. Riggs BL, Melton LJ III. Involutional osteoporosis. N Engl J Med 1986;314:1676–1686.

    Article  CAS  PubMed  Google Scholar 

  7. Melton LJ III, Riggs BL. Clinical spectrum. In: Riggs, BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York: Raven Press, 1988:155–179.

    Google Scholar 

  8. Krolner B, Toft B. Vertebral bone loss; an unheeded side effect of therapeutic bed rest. Clin Sci 1983;64:537–540.

    CAS  PubMed  Google Scholar 

  9. Fraser SA, Smith DA, Anderson JB, et al. Osteoporosis and fractures following thryotoxicosis. Lancet 1975;1:981–983.

    Google Scholar 

  10. Need AG. Corticosteroids and osteoporosis. Aust NZ J Med 1987;17:267–272.

    Article  CAS  Google Scholar 

  11. Richardson ML, Pozzi-Mucelli RS, Genant HK. Bone mineral changes in primary hyperparathyroidism. Skeletal Radiol 1986;15:85–95.

    Article  CAS  PubMed  Google Scholar 

  12. Verstraeten A, Dequeker J. Vertebral and peripheral bone mineral content and fracture incidence in post-menopausal patients with rheumatoid arthritis: Effect of low dose corticosteroids. Ann Rheum Dis 1986;45:852–857.

    Article  PubMed  Google Scholar 

  13. Seeman E, Melton LJ III, O’Fallon WM, et al. Risk factors for spinal osteoporosis in men. Am J Med 1983;75:977–983.

    Article  CAS  PubMed  Google Scholar 

  14. Ingeberg S, Deding A, Jensen MK. Bone mineral content in myelomatosis. Acta Med Scand 1982;211:19–21.

    Article  CAS  PubMed  Google Scholar 

  15. Holbrook TL, Grazier K, Kelsey JL, et al. The Frequency of Occurrence, Impact and Cost of Selected Musculoskeletal Conditions in the United States. Chicago: American Academy of Orthopedic Surgeons, 1984.

    Google Scholar 

  16. Cummings SR, Kelsey JL, Nevitt MC, et al. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 1985;7:178–208.

    CAS  PubMed  Google Scholar 

  17. Peck WA, Riggs BL, Bell NH, et al. Research directions in osteoporosis. Am J Med 1988;84:275–282.

    Article  CAS  PubMed  Google Scholar 

  18. Miller CW. Survival and ambulation following hip fracture. J Bone Joint Surg 1978;60A:930–934.

    Google Scholar 

  19. Jensen JS, Tondevold E. Morbidity after hip fractures. Acta Orthop Scand 1979;50:161–167.

    Article  CAS  PubMed  Google Scholar 

  20. Gallagher JC, Melton LJ, Riggs BL, et al. Epidemiology of fractures of the proximal femur in Rochester, Minnesota. Clin Orthop Rel Res 1980;150:163–171.

    Google Scholar 

  21. Melton LJ, Riggs BL. Epidemiology of age-related fractures. In: Avioli LV, ed. The Osteoporotic Syndrome: Detection, Prevention, and Treatment. New York: Grune and Stratton, 1983;45–72.

    Google Scholar 

  22. Melton LJ III. Epidemiology of fractures. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York: Raven Press, 1988;133 154.

    Google Scholar 

  23. Peck WA, Woods W The cells of bone. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York: Raven Press, 1988;1–44.

    Google Scholar 

  24. Eriksen EF, Colvard DS, Berg NJ, et al. Evidence of estrogen receptors in normal human osteoblast-like cells. Science 1988;241:84–86.

    Article  CAS  PubMed  Google Scholar 

  25. Doyle FH. Age-related bone changes in women. A quantitative X-ray study of the distal third of the ulna in normal subjects. In: Whedon GD, Cameron JR, eds. Progress in Methods of Bone Mineral Measurement. Washington; U.S. Department of Health, Education, and Welfare, 1968.

    Google Scholar 

  26. Garn SM. The phenomenon of bone formation and bone loss. In: DeLuca HF, Frost HM, Jee WSS, et al. eds. Osteoporosis; Recent Advances in Pathogenesis and Treatment. Baltimore: University Park Press, 1981;3–16.

    Google Scholar 

  27. Riggs BL, Wahner HW, Dunn WL, et al. Differential changes in bone mineral density of the appendicular and axial skeleton with aging; relationship to spinal osteoporosis. J Clin Invest 1981;67:328–335.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Krolner B, Nielsen SP. Bone mineral content of the lumbar spine in normal and osteoporotic women: Cross-sectional and longitudinal studies. Clin Sci 1982;62: 329–336.

    CAS  PubMed  Google Scholar 

  29. Riggs BL, Wahner HW, Melton LJ III, et al. Rates of bone loss in the appendicular and axial skeletons of women. J Clin Invest 1986;77:1487–1491.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Smith RW, Rizek J. Epidemiologic studies of osteoporosis in women of Puerto Rico and southeastern Michigan with special reference to age, race, national origin and to other related or associated findings. Clin Orthop Rel Res 1966;45:31–48.

    Google Scholar 

  31. Kelsey JL. Epidemiology of osteoporosis and associated fractures. In: Peck WA, ed. Bone and Mineral Research/5. Amsterdam: Elsevier, 1987;409–444.

    Google Scholar 

  32. Alderman BW, Weiss NS, Daling JR, et al. Reproductive history and postmenopausal risk of hip and forearm fracture. Am J Epidemiol 1986;124:262–267.

    CAS  PubMed  Google Scholar 

  33. Aloia JF, Cohn SH, Vaswani A, et al. Risk factors for postmenopausal osteoporosis. Am J Med 1985;78:95–100.

    Article  CAS  PubMed  Google Scholar 

  34. Farmer ME, White LR, Brody JA, et al. Race and sex differences in hip fracture incidence. Am J Public Health 1984;74:1374–1380.

    Article  CAS  PubMed  Google Scholar 

  35. Smith DM, Nance WE, Kang KW, et al. Genetic factors in determining bone mass. J Clin Invest 1973;52:2800–2808.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  36. Pocock NA, Eisman JA, Hopper JL, et al. Genetic determinants of bone mass in adults; a twin study. J Clin Invest 1987;87:706–710.

    Article  Google Scholar 

  37. Bikle DD, Genant HK, Cann C, et al. Bone disease in alcohol abuse. Ann Intern Med 1985;103:42–48.

    Article  CAS  PubMed  Google Scholar 

  38. Jensen J, Christiansen C, Rodbro P. Cigarette smoking, serum oestrogens, and bone loss during hormone replacement therapy early after menopause. N Engl J Med 1985;313:973–975.

    Article  PubMed  Google Scholar 

  39. Matkovic V, Kostial K, Simonovic I, et al. Bone status and fracture rates in two regions of Yugoslavia. Am J Clin Nutr 1979;32:540–549.

    CAS  PubMed  Google Scholar 

  40. Sandler RB, Slemenda CW, LaPorte RE, et al. Postmenopausal bone density and milk consumption in childhood and adolescence. Am J Clin Nutr 1985;42:270–274.

    CAS  PubMed  Google Scholar 

  41. Newcomer AP, Hodgson SF, McGill DB, et al. Lactase deficiency: Prevalence in osteoporosis. Ann Intern Med 1978;89:218–220.

    Article  CAS  PubMed  Google Scholar 

  42. Finkenstedt G, Skrabal F, Gasser RW, et al. Lactose absorption, milk consumption, and fasting blood glucose concentrations in women with idiopathic osteoporosis. Br Med J 1986;292:161–162.

    Article  CAS  Google Scholar 

  43. Vigorita VJ, Lane JM, Suda MK, et al. Differences between lactase deficient and non-lactase deficient women with spinal osteoporosis. Clin Orthop Rel Res 1987;215:248–253.

    Google Scholar 

  44. Drinkwater BL, Nilson K, Chesnut CH III, et al. Bone mineral content of amnenor-rheic and eumenorrheic athletes. N Engl J Med 1984;311:277–281.

    Article  CAS  PubMed  Google Scholar 

  45. Marcus E, Cann C, Madvig P, et al. Menstrual function and bone mass in elite women distance runners; endocrine and metabolic factors. Ann Intern Med 1985;102:158–163.

    Article  CAS  PubMed  Google Scholar 

  46. Rigotti NA, Nussbaum SR, Herzog DB, et al. Osteoporosis in women with anorexia nervosa. N Engl J Med 1984;311:1601–1606.

    Article  CAS  PubMed  Google Scholar 

  47. Szmukler GI, Brown SW, Parsons V, et al. Premature loss of bone in chronic anorexia nervosa. Br Med J 1985;290:26–27.

    Article  CAS  Google Scholar 

  48. Klibanski A, Neer RM, Beitins IZ, et al. Decreased bone density in hyperprolacti-nemic women. N Engl J Med 1980;303:1511–1514.

    Article  CAS  PubMed  Google Scholar 

  49. Endres DB, Morgan CH, Garry PJ, et al. Age-related changes in serum immunoreac-tive parathyroid hormone and its biological action in healthy men and women. J Clin Endocrinol Metab 1987;65:724–731.

    Article  CAS  PubMed  Google Scholar 

  50. Forero MS, Klein RF, Nissenson RA, et al. Effect of age on circulating immunoreac-tive and bioactive parathyroid hormone levels in women. J Bone Min Res 1987;2:363–366.

    Article  CAS  Google Scholar 

  51. Tiegs RD, Body JJ, Wahner HW, et al. Calcitonin secretion in postmenopausal osteoporosis. N Engl J Med 1985;312:1097–1100.

    Article  CAS  PubMed  Google Scholar 

  52. Young G, Marcus R, Minkoff JR, et al. Age-related rise in parathyroid hormone in man. The use of intact and midmolecule antisera to distinguish hormone secretion from retention. J Bone Min Res 1987;2:367–374.

    Article  CAS  Google Scholar 

  53. Tsai K-S, Wahner W, Offord KP, et al. Effect of aging on vitamin D stores and bone density in women. Calcif Tissue Int 1987;40:241–243.

    Article  CAS  PubMed  Google Scholar 

  54. Omdahl JL, Garry PJ, Hunsaker LA, et al. Nutritional status in a healthy elderly population: Vitamin D. Am J Clin Nutr 1982;36:1225–1233.

    CAS  PubMed  Google Scholar 

  55. Slovik DM, Adams JS, Neer RM, et al. Deficient production of 1,25-dihydroxy-vitamin D in elderly osteoporotic patients. N Engl J Med 1981;305:372–374.

    Article  CAS  PubMed  Google Scholar 

  56. Marcus R. The relationship of dietary calcium to the maintenance of skeletal integrity in man—an interface of endocrinology and nutrition. Metabolism 1982;31: 93–102.

    Article  CAS  PubMed  Google Scholar 

  57. Abraham S, Carroll MD, Dresser CM, et al. Dietary Intake Findings, United States 1971–1974, HEW Publication (HRA) 77–1647. Hyattsville, MD: National Center for Health Statistics, 1977.

    Google Scholar 

  58. Carroll MD, Abraham S, Dresser CM. Dietary Intake Source Data, 1976–1980. DHHS Publication (PHS) 83–1681. Washington; U.S. Government Printing Office, 1983.

    Google Scholar 

  59. Heaney RP. Calcium, bone health and osteoporosis. In: Peck WA, ed. Bone and Mineral Research/4. Elsevier: Amsterdam, 1986;255–301.

    Google Scholar 

  60. Heaney RP. Nutritional factors in bone health. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York: Raven Press, 1988;359–372.

    Google Scholar 

  61. Brown JP, Malaval L, Chapuy MC, et al. Serum bone gla-protein: A specific marker for bone formation in postmenopausal osteoporosis. Lancet 1984;1:1091–1093.

    Article  CAS  PubMed  Google Scholar 

  62. Ismail F, Epstein S, Pacifici R, et al. Serum bone gla protein (BGP) and other markers of bone mineral metabolism in postmenopausal osteoporosis. Calcif Tissue Int 1986;39:230–233.

    Article  CAS  PubMed  Google Scholar 

  63. Christiansen C, Riis BJ, Rodbro P. Prediction of rapid bone loss in postmenopausal women. Lancet 1987;1:1105–1108.

    Article  CAS  PubMed  Google Scholar 

  64. Slemenda C, Hui SL, Longcope C, et al. Sex steroids and bone mass; a study of changes about the time of menopause. J Clin Invest 1987;80:1261–1269.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  65. Mazess RB. The noninvasive measurement of skeletal mass. In: Peck WA, ed. Bone and Mineral Research, Annual 1. Amsterdam: Excerpta Medica, 1983;223–279.

    Google Scholar 

  66. Genant HK, Volger JB, Block JE. Radiology of osteoporosis. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York: Raven Press, 1988;181–220.

    Google Scholar 

  67. Lehmann LA, Alvarez RE, Macovski A, et al. Generalized image combinations in dual KVP digital radiography. Med Phys 1981;8:659–667.

    Article  CAS  PubMed  Google Scholar 

  68. Stein JA, Hochberg AM. Quantitative digital radiography for bone mineral analysis. In: Proceedings, Second International Workshop on Noninvasive Bone Measurement, Leuven, Belgium, September 25–27, 1987.

    Google Scholar 

  69. Johnston CC Jr. Studies on prevention of age-related bone loss. In: Peck WA, ed. Bone and Mineral Research/3. Amsterdam: Elsevier, 1985;233–257.

    Google Scholar 

  70. Gallagher JC. Drug therapy of osteoporosis: Calcium, estrogen, and vitamin D. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York: Raven Press, 1988;389–401.

    Google Scholar 

  71. Lobo, RA. Prevention of postmenopausal osteoporosis. In: Mishell DR, ed. Menopause: Physiology and Pharmacology. London: Year Book, 1987;165–186.

    Google Scholar 

  72. Christiansen C, Christensen MS, McNair P, et al. Prevention of early postmenopausal bone loss: Controlled 2-year study in 315 normal females. Eur J Clin Invest 1980;10:273–279.

    Article  CAS  PubMed  Google Scholar 

  73. Hutchinson TA, Polansky JM, Feinstein AR. Postmenopausal estrogens protect against fracture of hip and distal radius. Lancet 1979;2:705–709.

    Article  CAS  PubMed  Google Scholar 

  74. Weiss NS, Ure CL, Ballard JH, et al. Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen. N Engl J Med 1980;303: 1195–1198.

    Article  CAS  PubMed  Google Scholar 

  75. Krieger N, Kelsey JL, Hulford TR. An epidemiological study of hip fracture in postmenopausal women. Am J Epidemiol 1982;116:141–148.

    Google Scholar 

  76. Ettinger B, Genant HK, Cann CE. Long-term estrogen replacement therapy prevents bone loss and fracture. Ann Intern Med 1985;102:319–321.

    Article  CAS  PubMed  Google Scholar 

  77. Hoover R, Glass A, Finkle WD, et al. Conjugated estrogens and breast cancer risk in women. JNCI 1981;67:815–820.

    CAS  PubMed  Google Scholar 

  78. Brinton LA, Hoover RN, Szklo M, et al. Menopausal estrogen use and risk of breast cancer. Cancer 1981;47:2517–2522.

    Article  CAS  PubMed  Google Scholar 

  79. Hulka BS, Chambless LE, Deubner DC, et al. Breast cancer and estrogen replacement therapy. Am J Obstet Gynecol 1982;143:638–644.

    CAS  PubMed  Google Scholar 

  80. Kaufman DW, Miller DR, Rosenberg L, et al. Noncontraceptive estrogen use and the risk of breast cancer. JAMA 1984;252:63–67.

    Article  CAS  PubMed  Google Scholar 

  81. Whitehead MI, Townsend PT, Pryse-Davies J, et al. Effects of estrogens and progestins on the biochemistry and morphology of the postmenopausal endometrium. N Engl J Med 1981;305:1599–1605.

    Article  CAS  PubMed  Google Scholar 

  82. Buring JE, Bain CJ, Ehrmann RL. Conjugated estrogen use and risk of endometrial cancer. Am J Epidemiol 1986;124:434–441.

    CAS  PubMed  Google Scholar 

  83. Schwartzbaum JA, Hulka BS, Fowler WC Jr, et al. The influence of exogenous estrogen use on survival after diagnosis of endometrial cancer. Am J Epidemiol 1987;126:851–860.

    CAS  PubMed  Google Scholar 

  84. Gambrell RD. Preventing endometrial cancer with progestin. Contemp Obstet Gynecol 1981;17:133.

    Google Scholar 

  85. Persson IR, Adami HO, Eklund G, et al. The risk of endometrial neoplasia and treatment with estrogens and estrogen-progestogen combinations. First results of a cohort study after one to four completed years of observation. Acta Obstet Gynecol Scand 1986;65:211–217.

    Article  CAS  PubMed  Google Scholar 

  86. Gambrell RD Jr. Safety of long-term estrogen-progestogen replacement. A Special Report: The Long-Term Effect of Estrogen Deprivation. Postgrad Med 1987; Sept 14;71–80.

    Google Scholar 

  87. Bush TL, Barrett-Conner E. Noncontraceptive estrogen use and cardiovascular disease. Epidemiol Rev 1985;7:80–104.

    Google Scholar 

  88. Riis B, Thomsen K, Christiansen C. Does calcium supplementation prevent postmenopausal bone loss? A double-blind, controlled clinical study. N Engl J Med 1987;316:173–177.

    Article  CAS  PubMed  Google Scholar 

  89. Recker RR, Saville PD, Heaney RP. Effect of estrogens and calcium carbonate on bone loss in postmenopausal women. Ann Intern Med 1987;87:649–655.

    Article  Google Scholar 

  90. Horsman A, Gallagher JC, Simpson M, et al. Prospective trial of oestrogen and calcium in postmenopausal women. Br Med J 1977;2:789–792.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  91. Ettinger B, Genant HK, Cann CE. Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium. Ann Intern Med 1987;106:40–45.

    Article  CAS  PubMed  Google Scholar 

  92. Sheikh MS, Santa Ana CA, Nicar MJ. Gastrointestinal absorption of calcium from milk and calcium salts. N Engl J Med 1987;317:532–536.

    Article  CAS  PubMed  Google Scholar 

  93. Smith KT, Heaney RP, Flora L, et al. Calcium absorption from a new calcium delivery system (CCM). Calcif Tissue Int 1987;41:351–352.

    Article  CAS  PubMed  Google Scholar 

  94. Carr CJ, Shangraw RF. Nutritional and pharmaceutical aspects of calcium supplementation. Am Pharm 1987;NS27:149–157.

    Google Scholar 

  95. Nicar MJ, Pak CYC. Calcium bioavailability from calcium carbonate and calcium citrate. J Clin Endocrinol Metab 1985;61:391–393.

    Article  PubMed  Google Scholar 

  96. Recker R. Calcium absorption and achlorhydria. N Engl J Med 1985;313:70–73.

    Article  CAS  PubMed  Google Scholar 

  97. Gruber HE, Ivey JL, Baylink DJ, et al. Long-term calcitonin therapy in postmenopausal osteoporosis. Metabolism 1984;33:295–303.

    Article  CAS  PubMed  Google Scholar 

  98. Aloia JF, Vaswani A, Kapoor A, et al. Treatment of osteoporosis with calcitonin, with and without growth hormone. Metabolism 1985;34:124–129.

    Article  CAS  PubMed  Google Scholar 

  99. Gnudi S, Maggi G, Figus E, et al. Efficacy of calcitonin in the symptomatic control of chronic backache due to senile osteoporosis. Clin Ter 1986;118:119–124.

    CAS  PubMed  Google Scholar 

  100. Reginster JY, Albert A, Lecart MP, et al. One-year controlled randomised trial of prevention of early postmenopausal bone loss by intranasal calcitonin. Lancet 1987;2:1481–1483.

    Article  CAS  PubMed  Google Scholar 

  101. Smith EL. Exercise for prevention of osteoporosis: A review. Phys Sports Med 1982;10:72–83.

    Google Scholar 

  102. Pocock NA, Elsman JA, Yeates MG, et al. Physical fitness is a major determinant of femoral neck and lumbar spine bone mineral density. J Clin Invest 1986;78:618–621.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  103. Aloia JF, Stanton H, Ostuni JA, et al. Prevention of involutional bone loss by exercise. Ann Intern Med 1978;89:356–358.

    Article  CAS  PubMed  Google Scholar 

  104. Krolner B, Toft B, Nielsen SP. Physical exercise as prophylaxis against involutional vertebral bone loss: A controlled trial. Clin Sci 1983;64:541–546.

    CAS  PubMed  Google Scholar 

  105. Chou R, Harrison JE, Notarius C. Effect of two randomised exercise programmes on bone mass of healthy postmenopausal women. Br Med J 1987;295:1441–1444.

    Article  Google Scholar 

  106. Peck WA, Riggs BL, Bell NH, et al. Research directions in osteoporosis. Am J Med 1988;84:275–282.

    Article  CAS  PubMed  Google Scholar 

  107. Eriksen EF, Hodgson SF, Riggs BL. Treatment of osteoporosis with sodium fluoride. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York: Raven Press, 1988;415–432.

    Google Scholar 

  108. Slovik DM, Rosenthal DI, Doppelt SH, et al. Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1–34) and 1,25-dihydroxyvitamin D. J Bone Mineral Res 1986;1:377–381.

    Article  CAS  Google Scholar 

  109. Woodson GC. Coherence therapy with phosphate and etidronate for osteoporosis: Preliminary results. In: Christiansen C, Johansen JS, Riis BJ, eds. Osteoporosis 1987; International Symposium on Osteoporosis, Denmark, September 27-October 2, 1987. Copenhagen; Osteopress, 1987; 1188–1189.

    Google Scholar 

  110. Storm T, Thamsborg G, Sorensen O, et al. The effects of etidronate therapy in postmenopausal osteoporotic women: Preliminary results. In: Christiansen C, Johansen JS, Riis BJ, eds. Osteoporosis 1987; International Symposium on Osteoporosis, Denmark, September 27-October 2, 1987. Copenhagen; Osteopress, 1987; 1172–1176.

    Google Scholar 

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  1. William A. Peck
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Editors and Affiliations

  1. Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, St. Louis, Missouri, 63125, USA

    H. James Armbrecht Ph.D. , Rodney M. Coe Ph.D.  & Nirandon Wongsurawat M.D., F.A.C.P. ,  & 

  2. Department of Internal Medicine, St. Louis University School of Medicine, St. Louis, Missouri, 63104, USA

    H. James Armbrecht Ph.D. , Rodney M. Coe Ph.D.  & Nirandon Wongsurawat M.D., F.A.C.P. ,  & 

  3. Department of Biochemistry, St. Louis University School of Medicine, St. Louis, Missouri, 63104, USA

    H. James Armbrecht Ph.D.

  4. Department of Community Medicine, St. Louis University School of Medicine, St. Louis, Missouri, 63104, USA

    Rodney M. Coe Ph.D.

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Peck, W.A. (1990). Diagnosis and Treatment of Osteoporosis. In: Armbrecht, H.J., Coe, R.M., Wongsurawat, N. (eds) Endocrine Function and Aging. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3240-7_6

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  • DOI: https://doi.org/10.1007/978-1-4612-3240-7_6

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