Cholesterol and Age-Related Changes in Adrenal Steroidogenesis

  • Salman Azhar
  • Philip Y. Popplewell
  • Eve Reaven


Although there is some controversy in the literature concerning the effect of age on adrenal function,1–5 a number of studies in rodents suggest that aging is accompanied by a decline in corticosterone secretion.5 It is not certain, however, whether there is a primary defect in the adrenal gland itself or the altered corticosterone response is more directly related to changes in other tissues, which subsequently influence the adrenal response. The best evidence to date to support the view that the adrenal is itself (at least in rodents) a primary target for aging changes comes from the work of Malamed and Carsia6 as well as our own studies7 on isolated rat adrenocortical cells. Malamed and Carsia6 recently reported that ACTH (or dibutyryl [Bt2] cAMP)-induced corticosterone production by adrenal cells isolated from male Long-Evans rats progressively declined as the rats aged from 2 to 24 months. We confirmed this decline in the aging Sprague-Dawley strain7 and, as summarized below, have gone on to describe several related defects in adrenal cells of this strain of rats that we believe may be the basis of the deceased steroidogenesis.


Cholesteryl Ester Adrenal Cell Adrenocortical Cell Corticosterone Secretion Adrenal Steroidogenesis 
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Copyright information

© Springer Science+Business Media New York  1990

Authors and Affiliations

  • Salman Azhar
  • Philip Y. Popplewell
  • Eve Reaven

There are no affiliations available

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