Skip to main content

Inhibition of Human Mixed Lymphocyte Reactions by Monoclonal Antibodies to Intercellular Adhesion Molecule-1 (ICAM-1)

  • Conference paper
Leukocyte Adhesion Molecules

Abstract

Cell-cell adhesion is believed to be an integral event in the development of effective immunological responses. A family of molecules has been described which mediate leukocyte cell-cell and cell-substrate adhesions and are necessary for cell migration through endothelium. This family has been designated the lymphocyte function-associated antigen-1 (LFA-1)1 family or the CD18 complex of adhesion molecules (1–10).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sanchez-Madrid F, Nagy J, Robbins E, Simon P, Springer TA: A human leukocyte differentiation antigen family with distinct alpha subunits and a common beta subunit: The lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule. J Exp Med 158:1785, 1983.

    Article  PubMed  CAS  Google Scholar 

  2. Mentzer SJ, Gromkowski SH, Krensky AM, Burakoff SJ, Martz E: LFA-1 membrane molecule in the regulation of homotypic adhesions of human B lymphocytes. J Immunol 135:9, 1985.

    PubMed  CAS  Google Scholar 

  3. Rothlein R, Springer TA: The requirement for function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester. J Exp Med 163:1132, 1986.

    Article  PubMed  CAS  Google Scholar 

  4. Martz E: LFA-1 and other accessory molecules functioning in adhesions of T and B lymphocytes. Human Immunol 18:3, 1986.

    Article  Google Scholar 

  5. Springer TA, Dustin ML, Kishimoto TK, Marlin SD: The lymphocyte function-associated LFA-1 CD2, and LFA-3 molecules: Adhesion receptors of the immune system. Ann Rev Immunol 5:223, 1987.

    Article  CAS  Google Scholar 

  6. Anderson DC, Schmalsteig FC, Finegold MJ, Hughes BJ, Rothlein RR, Miller LJ, Kohl S, Tosi MF, Jacobs RL, Waldrop TC, Goldman AS, Shearer WT, Springer TA: The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: Their quantitative definition and relation to leukocyte dysfunction and clinical features. J Inf Dis 152:668, 1985.

    Article  CAS  Google Scholar 

  7. Anderson DC, Springer TA: Leukocyte adhesion deficiency: An inherited defect in the Mac-1, LFA-1, and p150, 95 glycoproteins. Ann Rev Med 38:175, 1987.

    Article  PubMed  CAS  Google Scholar 

  8. Schleimer RP, Rutledge BK: Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin 1, endotoxin and tumor promoting phorbol diesters. J Immunol 136:649, 1986.

    PubMed  CAS  Google Scholar 

  9. Dustin ML, Rothlein R, Bhan AK, Dinarello CD, Springer TA: Induction by IL 1 and interferon-y: Tissue distribution, biochemistry and function of a natural adherence molecule (ICAM-1). J Immunol 137:245, 1986.

    PubMed  CAS  Google Scholar 

  10. Pober JS, Gimbrone Jr MA, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, Springer TA: Activation of human endothelial cells by lymphokines: Overlapping patterns of antigenic modulation by interleukin 1, tumor necrosis factor and immune interferon. J Immunol 137:1893, 1986.

    PubMed  CAS  Google Scholar 

  11. Rothlein RR, Dustin ML, Marlin SD, Springer TA: A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 137:1270, 1986.

    PubMed  CAS  Google Scholar 

  12. Marlin SD, Springer TA: Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1).Cell 51:813, 1987.

    Article  PubMed  CAS  Google Scholar 

  13. Makgoba MW, Sanders ME, Luce GEG, Dustin ML, Springer TA, Clarke EA, Mannoni P, Shaw S: ICAM-1 a ligand for LFA-1 dependent adhesion of B, T and myeloid cells. Nature 331:86, 1988.

    Article  PubMed  CAS  Google Scholar 

  14. Fischer A, Blanche S, Veber F, Delaage M, Mawas C, Griscelli C, LeDeist F, Lopez M, Olive D, Janossy G: Prevention of graft failure by an anti-HLFA-1 monoclonal antibody in HLA-mismatched bone-marrow transplantation. Lancet 1:1058, 1986.

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag New York Inc.

About this paper

Cite this paper

Merluzzi, V.J., Rothlein, R., Wood, C., Stearns, C.D., Faanes, R.B., Last-Barney, K. (1990). Inhibition of Human Mixed Lymphocyte Reactions by Monoclonal Antibodies to Intercellular Adhesion Molecule-1 (ICAM-1). In: Springer, T.A., Anderson, D.C., Rothlein, R., Rosenthal, A.S. (eds) Leukocyte Adhesion Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3234-6_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-3234-6_20

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7927-3

  • Online ISBN: 978-1-4612-3234-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics