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Immunoregulatory CD4+ T Cell Subpopulations: Enumeration, Activation, and Functional Analyses in Normals and Autoimmune Disease

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Topics in Pediatrics

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Abstract

Our understanding of the regulation of the normal immune response by T cells has been advanced enormously by the recognition of two distinct subsets of mature T cells. Inducer T cells that express the CD4 cell surface glycoprotein recognize antigen when it is presented by accessory cells in the context of class II self-histocompatibility determinants—eg, HLA-DR, -DQ, -DP.1 Suppressor/cytotoxic T cells that bear the CD8 surface molecule recognize antigen along with MHC class I determinants—eg, HLA-A and -B.1 It is now clear that CD4+ T cells play a pivotal role in the induction and regulation of a variety of immunological events. These include antigen-specific or polyclonal B cell activation, proliferation and differentiation of B cells into immunoglobulin producing cells, delayed type hypersensitivity, induction of CD8+ suppressor or cytotoxic T cells, and killing of appropriate target cells.

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Authors and Affiliations

  1. Division of Immunology and Transplantion, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA

    Douglas J. Barrett, Desmond A. Schatz & John W. Sleasman

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  1. Douglas J. Barrett
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  2. Desmond A. Schatz
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  3. John W. Sleasman
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Editors and Affiliations

  1. University of South Florida College of Medicine, 33612, Tampa, Florida, USA

    Herbert H. Pomerance MD (Professor of Pediatrics, Professor Emeritus) & Barry B. Bercu MD (Professor of Pediatrics) (Professor of Pediatrics, Professor Emeritus) &  (Professor of Pediatrics)

  2. Department of Pediatrics, West Virgina University College Of Medicine, Morgantown, West Virginia, USA

    Herbert H. Pomerance MD (Professor of Pediatrics, Professor Emeritus) (Professor of Pediatrics, Professor Emeritus)

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© 1990 Springer-Verlag New York Inc.

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Barrett, D.J., Schatz, D.A., Sleasman, J.W. (1990). Immunoregulatory CD4+ T Cell Subpopulations: Enumeration, Activation, and Functional Analyses in Normals and Autoimmune Disease. In: Pomerance, H.H., Bercu, B.B. (eds) Topics in Pediatrics. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3230-8_8

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  • DOI: https://doi.org/10.1007/978-1-4612-3230-8_8

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7925-9

  • Online ISBN: 978-1-4612-3230-8

  • eBook Packages: Springer Book Archive

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