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The Role of Oxidation in Diseases of the Human Erythrocyte

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Topics in Pediatrics

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Abstract

Considerable evidence exists that red blood cells (RBC) are oxidatively damaged in vivo.1–10 Since these cells have limited ability to repair such damage, the cumulative injury resulting from oxidation can contribute to cell death. In red cells characterized by congenital or acquired structural defects, susceptibility to oxidant injury is often increased.2 However, the extent to which oxidant injury contributes to shortened survival of these RBC is not clearly determined. We will discuss factors that render the red cell susceptible to oxidant injury, review several clinical disorders in which red cell oxidant injury has been reported, and provide a rationale for designing therapies to prevent oxidative damage.

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Author information

Authors and Affiliations

  1. Children’s Hospital Oakland Research Institute, 33612, Oakland, California, USA

    Bertram Lubin, Frans Kuypers & Elliott Vichinsky

  2. Centre for Advanced Medical Technology, 33612, San Francisco, California, USA

    Daniel Chiu

Authors
  1. Bertram Lubin
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  2. Frans Kuypers
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  3. Elliott Vichinsky
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  4. Daniel Chiu
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Editors and Affiliations

  1. University of South Florida College of Medicine, 33612, Tampa, Florida, USA

    Herbert H. Pomerance MD (Professor of Pediatrics, Professor Emeritus) & Barry B. Bercu MD (Professor of Pediatrics) (Professor of Pediatrics, Professor Emeritus) &  (Professor of Pediatrics)

  2. Department of Pediatrics, West Virgina University College Of Medicine, Morgantown, West Virginia, USA

    Herbert H. Pomerance MD (Professor of Pediatrics, Professor Emeritus) (Professor of Pediatrics, Professor Emeritus)

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Lubin, B., Kuypers, F., Vichinsky, E., Chiu, D. (1990). The Role of Oxidation in Diseases of the Human Erythrocyte. In: Pomerance, H.H., Bercu, B.B. (eds) Topics in Pediatrics. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3230-8_5

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  • DOI: https://doi.org/10.1007/978-1-4612-3230-8_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7925-9

  • Online ISBN: 978-1-4612-3230-8

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