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Granulocyte-Macrophage Colony-Stimulating Factor

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Book cover Peptide Growth Factors and Their Receptors I

Part of the book series: Springer Study Edition ((SSE))

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Abstract

The control of blood cell production is modulated directly or indirectly by more than ten different hematopoietic growth factors (Metcalf 1984). Many names have been assigned to each of the hematopoietic growth factors: although a specific set of names is used throughout this article, the alternative names can be found in other reviews (Nicola and Vadas 1984; Metcalf 1985; Arai et al. 1986; Morstyn and Burgess 1988). Six of these growth factors appear to be capable of stimulating the proliferation of hematopoietic progenitor cells — multi-colony-stimulating factor (multi-CSF, also called interleukin-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF, also called CSF-1), interleukin-5 (also called eosinophil differentiation factor), and erythropoietin. The existence of these different growth factors had been apparent for almost 20 years, but in the last 5 years all of these molecules have been purified, cloned, and expressed. We know that there is no structural relationship between the regulators, but there is a considerable overlap in their biological activities.

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  1. A. W. Burgess
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  1. Laboratory of Chemoprevention, National Cancer Institute, 20892, Bethesda, MD, USA

    Michael B. Sporn M.D.  & Anita B. Roberts Ph.D.  & 

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Burgess, A.W. (1991). Granulocyte-Macrophage Colony-Stimulating Factor. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Springer Study Edition. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3210-0_17

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  • DOI: https://doi.org/10.1007/978-1-4612-3210-0_17

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