Follicular Progesterone Production Stimulated by TNF α Is Modulated by PKC and Calcium

  • Maria Sancho-Tello
  • Katherine F. Roby
  • Paul F. Terranova
Part of the Serono Symposia USA book series (SERONOSYMP)


Tumor necrosis factor a (TNF α) stimulates progesterone (PR) production by preovulatory rat follicles in vitro (1, 2); however, TNF α-stimulated PR levels never reached those obtained after incubation with comparable doses of luteinizing hormone (LH), indicating the possibility of a different signal transduction mechanism. TNF α stimulates arachidonic acid release (3), involving cyclooxygenase and/or lipoxygenase pathways (4) and prostaglandin (PG) production (5), which ultimately may stimulate cAMP synthesis (6), or it may directly activate the cAMP-dependent pathway (7). Several studies revealed that protein kinase C (PKC) activators and/or inhibitors can alter TNF α action (8–10), while another study reported no relation between TNF α and PKC (7).


Luteinizing Hormone Granulosa Cell Luteal Cell Arachidonic Acid Release Calcium Ionophore A23187 
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© Springer-Verlag New York, Inc. 1991

Authors and Affiliations

  • Maria Sancho-Tello
  • Katherine F. Roby
  • Paul F. Terranova

There are no affiliations available

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