Oxysterols: Regulation of Biosynthesis and Role in Controlling Cellular Cholesterol Homeostasis in Ovarian Cells

  • Jerome F. StraussIII
  • Hannah Rennert
  • Ritsu Yamamoto
  • Lee-Chuan Kao
  • Juan G. Alvarez
Part of the Serono Symposia USA book series (SERONOSYMP)


Steroid-producing cells obtain cholesterol for use in hormone synthesis by de novo synthesis from acetyl co-enzyme A or through accumulation of cholesterol from circulating lipoproteins. Tropic hormones, which augment steroidogenesis (e.g., pituitary gonadotropins acting on ovarian cells), increase both de novo sterol synthesis and lipoprotein cholesterol uptake. Recent review articles summarize the various observations documenting this regulation (1-4).


Chloramphenicol Acetyl Transferase Sterol Synthesis Human Granulosa Cell Sterol Carrier Protein Cerebrotendinous Xanthomatosis 
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© Springer-Verlag New York, Inc. 1991

Authors and Affiliations

  • Jerome F. StraussIII
  • Hannah Rennert
  • Ritsu Yamamoto
  • Lee-Chuan Kao
  • Juan G. Alvarez

There are no affiliations available

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