Transforming Growth Factors and Ovarian Function

  • David W. Schomberg
  • George W. Mulheron
Conference paper
Part of the Serono Symposia, USA book series (SERONOSYMP)


Transforming growth factor α (TGFα) is a 50-amino acid polypeptide that interacts with the same receptor as the epidermal growth factor (EGF) (1). It is, therefore, a regulatory molecule capable of affecting the same cell types, including epithelial cells, that respond to EGF (2). Transforming growth factor βs (TGFβs), on the other hand, are 25-kD peptides consisting of two identical 112-amino acid subunits that are synthesized as part of a larger, biologically latent peptide (3–4). They are considered to be part of a more extensive gene family that includes other ovarian effectors, such as inhibin, activin, and mullerian inhibiting substance (5). The cellular effects of TGFβs are multifactorial and are dependent upon other factors in the milieu, but in general, their effect upon epithelial cells is antimitotic (3). Two excellent reviews of the biochemical properties and cellular actions of TGFα and TGFβs are presented elsewhere in this volume.


Transform Growth Factor Granulosa Cell Thecal Cell Granulosa Cell Proliferation Porcine Granulosa Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag New York, Inc. 1991

Authors and Affiliations

  • David W. Schomberg
    • 1
    • 2
    • 3
  • George W. Mulheron
    • 1
    • 2
    • 3
  1. 1.Department of Obstetrics and GynecologyDuke University Medical CenterDurhamUSA
  2. 2.Department of Cell BiologyDuke University Medical CenterDurhamUSA
  3. 3.The Comprehensive Cancer CenterDuke University Medical CenterDurhamUSA

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