Expression and Function of Growth Factor Ligands and Receptors in Preimplantation Mouse Embryos

  • Daniel A. Rappolee
  • Karin S. Sturm
  • Gilbert A. Schultz
  • Claudio A. Basilico
  • Daniel Bowen-Pope
  • Roger A. Pedersen
  • Zena Werb
Conference paper
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

Because mouse preimplantation embryos grow and differentiate in the absence of exogenous factors, endogenous factors must sustain the embryo during the first six cleavage divisions (1). These early cleavage divisions serve two unique functions in mammals: (a) the generation of progenitors of the trophoblasts and extraembryonic membranes, and (b) the generation of the embryonic anlagen from the inner cell mass (ICM), and, hence, the embryo proper. Fate maps indicate that after implantation mammalian gastrulation and neurulation may be mechanistically and morphologically similar to that of nonmammalian vertebrates, such as Xenopus. However, unlike Xenopus, the unfertilized egg does not have partitioned cytosolic determinates, but must generate positional information during the six preimplantation cleavage divisions. Also, unlike the abbreviated synchronous cleavage cell cycles of Xenopus that precede gastrulation, mouse pre-implantation embryos have near-normal cell cycle times (2–4) that may be regulated by growth factors. The paradigm for intercellular regulation of growth and differentiation is the interaction of growth factor ligands and receptors.

Keywords

Estrogen Tyrosine Leukemia Sarcoma Polypeptide 

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Copyright information

© Springer-Verlag New York, Inc. 1991

Authors and Affiliations

  • Daniel A. Rappolee
    • 1
  • Karin S. Sturm
    • 1
  • Gilbert A. Schultz
    • 2
  • Claudio A. Basilico
    • 3
  • Daniel Bowen-Pope
    • 4
  • Roger A. Pedersen
    • 1
  • Zena Werb
    • 1
  1. 1.Laboratory of Radiobiology and Environmental Health and the Department of AnatomyUniversity of CaliforniaSan FranciscoUSA
  2. 2.Department of Medical BiochemistryUniversity of CalgaryAlbertaCanada
  3. 3.Department of Pathology and Kaplan Cancer CenterNew York University School of MedicineNew YorkUSA
  4. 4.Department of PathologyUniversity of Washington School of MedicineSeattleUSA

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