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Parasystole and the Pacemaker Problem

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Theory of Heart

Part of the book series: Institute for Nonlinear Science ((INLS))

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Abstract

In parasystole there is a competition between two independent cardiac pacemakers, the normal sinus rhythm and the abnormal ectopic rhythm, for the control of the heart. The physiological mechanism for parasystole has been translated into a mathematical model. Theoretical analysis of the model leads to a number of testable predictions concerning the occurrence of normal and ectopic beats in patients with parasystole. Tests of these predictions confirm the applicability of the model. The mathematical analysis uses approaches derived from number theory and nonlinear mathematics.

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References

  1. A. Castellanos, R.M. Luceri, F. Moleiro, et al. Annihilation, entrainment, and modulation of ventricular parasystolic rhythms. Am. J. Cardiol., 54: 317–322, 1984.

    Article  Google Scholar 

  2. M. Courtemanche, L. Glass, J. Bélair, D. Scagliotti, and D. Gordon. A circle map in a human heart. Physica D., 40: 299–310, 1989b.

    Article  MathSciNet  ADS  MATH  Google Scholar 

  3. M. Courtemanche, L. Glass, M.D. Rosengarten, and A.L. Goldberger. Beyond pure parasystole: Promises and problems in modelling complex cardiac arrhythmias. Am. J. Physiol., 257: H693-H706, 1989a.

    Google Scholar 

  4. R.L. Devaney. An Introduction to Chaotic Dynamical Systems. Benjamin-Cummins, Menlo Park, 1986.

    MATH  Google Scholar 

  5. P. Fernandez, A. Castellanos, G. Breuer, and A. Interian. Dynamic behavior of sinus beats during pure ventricular parasystole (abstract). Circulation., 80: SII: 40 (0157), 1989.

    Google Scholar 

  6. G.B. Fleming. Triple rhythm of the heart due to extrasystoles. Q. J. Med., 5: 318–326, 1912.

    Google Scholar 

  7. L. Glass, A.L. Goldberger, and J. Bélair. Dynamics of pure parasystole. Am. J. Physiol. 251: (Heart Circ. Physiol. 20): H841-H847, 1986.

    Google Scholar 

  8. L. Glass, A.L. Goldberger, M. Courtemanche, and A. Shrier. Nonlinear dynamics, chaos, and complex cardiac arrhythmias. Proc. Roy. Soc. Lond. A., 413: 9–16, 1987.

    Article  MathSciNet  ADS  MATH  Google Scholar 

  9. D. Gordon, D. Scagliotti, M. Courtemanche, and L. Glass. A clinical study of the dynamics of parasystole. PACE, 12: 1412–1418, 1989.

    Article  Google Scholar 

  10. G.H. Hardy and E.M. Wright. An Introduction to the Theory of Numbers, 4th ed. Clarendon, Oxford, 1971.

    Google Scholar 

  11. N. Ikeda, S. Yoshizawa, and T. Sato. Difference equation model of ventricular parasystole as an interaction of pacemakers based on the phase response curve. Theor. Biol., 103: 439–465, 1983.

    Article  MathSciNet  Google Scholar 

  12. J. Jalife, C. Antzelevitch, and G.K. Moe. The case for modulated parasystole. PACE, 5: 911–926, 1982.

    Google Scholar 

  13. J. Jalife and G.K. Moe. Effect of electrotonic potentials on pacemaker activity in canine Purkinje fibers. Circ. Res., 39: 801–808, 1976.

    Google Scholar 

  14. L. Kuipers and H. Niederreiter. Uniform Distribution of Sequences. John Wiley & Sons, New York, 1974.

    MATH  Google Scholar 

  15. M. Langevin. Stimulateur cardiaque et suites de Farey. 1990. (in press.)

    Google Scholar 

  16. M.N. Levy, N. Kerin, and I. Eisenstein. A subvariant of concealed bigeminy. J. Electrocardiol, 10: 225–232, 1977.

    Article  Google Scholar 

  17. P. Lightfoot. Parasystole simulating ventricular bigeminy with Wenckebach-type coupling prolongation. J. Electrocardiol., 11: 385–390, 1978.

    Article  Google Scholar 

  18. H.J.L. Marriot and H.J. Conover. Advanced Concepts in Arrhythmias. CV Mosby, St. Louis, 1983.

    Google Scholar 

  19. G.K. Moe, J. Jalife, W.J. Mueller, and B. Moe. A mathematical model of parasystole and its application to clinical arrhythmias. Circulation, 56: 968–979, 1977.

    Google Scholar 

  20. G.J. Nau, A.E. Aldariz, R.S. Acunzo, et al. Modulation of parasystolic activity by non-parasystolic beats. Circulation, 68: 462–469, 1982.

    Article  Google Scholar 

  21. G. Oreto, F. Luzza, G. Satullo, S. Coglitore, and L. Schamroth. Intermittent ventricular bigeminy as an expression of modulated parasystole. Am. J. Cardiol., 55: 1634–1637, 1985.

    Article  Google Scholar 

  22. G. Oreto, F. Luzza, G. Satullo, et al. The influence of sinus rhythm on a parasystolic focus. Am. Heart J., 115: 121–133, 1988.

    Article  Google Scholar 

  23. G. Oreto, F. Luzza, G. Satullo, and L. Schamroth. Modulated parasystole as a mechanism for concealed bigeminy. Am. J. Cardiol., 58: 954–958, 1986.

    Article  Google Scholar 

  24. I. Richards. Continued fractions without tears. Math. Mag., 54: 163–171, 1981.

    Article  MathSciNet  ADS  MATH  Google Scholar 

  25. L. Schamroth and H.J.L. Marriot. Intermittent ventricular parasystole with observations on its relationship to extrasystolic bigeminy. Am. J. Cardiol., 7: 799–809, 1961.

    Article  Google Scholar 

  26. L. Schamroth, D.H. Martin, and M. Pachter. The extrasystolic mechanism as the entrainment of an oscillator. Am. Heart J., 104: 1363–1368, 1988.

    Article  Google Scholar 

  27. N.B. Slater. Gaps and steps for the sequence nθ mod 1. Proc. Camb. Phil. Soc., 63: 1115–1123, 1967.

    Article  MathSciNet  ADS  MATH  Google Scholar 

  28. C.A. Swenne, P.A. Delang, M. Ten Hoopen, and N.M. Van Hemel. Computer simulations of ventricular arrhythmias: Ventricular bigeminy. Comput. Cardiol., 295–298, 1981.

    Google Scholar 

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© 1991 Springer-Verlag New York, Inc.

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Bélair, J., Courtemanche, M., Glass, L. (1991). Parasystole and the Pacemaker Problem. In: Glass, L., Hunter, P., McCulloch, A. (eds) Theory of Heart. Institute for Nonlinear Science. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3118-9_15

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  • DOI: https://doi.org/10.1007/978-1-4612-3118-9_15

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7803-0

  • Online ISBN: 978-1-4612-3118-9

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