Use of Clomiphene Citrate for Ovulation Induction
Clomiphene citrate (CC) is a nonsteroidal triphenylethylene compound currently used as the first choice of treatment for induction of ovulation in anovulatory or oligoovulatory women. It is suitable in cases in which endogenous gonadotropin secretion is desirable for induction of ovulation. Structurally, it is related to the potent synthetic estrogen diethylstilbestrol. At the recommended doses in humans, CC is an antiestrogen. Although the exact mechanism of action of an antiestrogen is not yet clear, CC binds to multiple target organs through the estrogen receptor machinery (i.e., it competes with estrogens for the receptor binding sites). The threshold of the antiestrogen effects of CC varies among tissue sites and depends on individual tissue estrogen receptor concentrations.
KeywordsPhene Estrogen Citrate Phenyl Tamoxifen
Unable to display preview. Download preview PDF.
- 3.Schreiber E, Johnson JE, Plotz EJ, et al. Studies with 14C labelled clomiphene citrate. Clin Res. 1966; 14: 287–89.Google Scholar
- 12.Poison DW, Kiddy DS, Mason HD, et al. Induction of ovulation with clomiphene citrate in women with polycystic ovary syndrome: the difference between responders and nonresponders. Fertil Steril. 1989; 51: 30–34.Google Scholar
- 16.Robertson S, Birrel W, Grant A. Fewer multiple pregnancies using clomiphene/human gonadotropin sequence. Fertil Steril. 1977; 28: 294.Google Scholar
- 17.Kistner RW. Induction of ovulation with clomiphene citrate, In: Behrman SG, Kistner RW, eds. Progress in infertility. Boston: Little, Brown, 1975: 509–36.Google Scholar