Dietary Treatment of Lipids and Lipoprotein Disorders

  • Byron J. Hoogwerf


Several observations underlie the rationale for dietary alteration of plasma lipids and lipoproteins, especially when they are elevated. First, epidemiologically based studies and longitudinal studies of selected population cohorts have shown a relation between elevated plasma cholesterol and risk for atherosclerotic vascular disease, especially coronary heart disease. Second, clinical intervention trials using diet and drugs have shown that reduction in total cholesterol and, more particularly, a reduction in low density lipoprotein cholesterol (LDL-C) reduces the risk for coronary heart disease events. Such trials have generally used a combination of dietary and pharmacological therapy. Third, nutritional studies have shown that dietary change may significantly lower cholesterol.


High Density Lipoprotein Cholesterol Total Calorie Atherosclerotic Vascular Disease Lipid Research Clinic Multiple Risk Factor Intervention Trial 
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© Springer-Verlag New York Inc. 1991

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  • Byron J. Hoogwerf

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