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Anti-Idiotypic Tumor Vaccines

  • Chapter
Anti-Idiotypic Vaccines

Part of the book series: Progress in Vaccinology ((VACCINOLOGY,volume 3))

  • 29 Accesses

Abstract

Host defense against cancer is known to be usually insufficient to halt the growth and the dissemination of the tumor. This may be due to ineffective stimulation of the lymphocyte clones, which have the potential to mount a response to tumor-associated antigens (TAAs) (1) or due to suppression of cytotoxic T lymphocyte activity by progressive tumor growth (2). A common explanation for the absence of antitumor immunity is that the immune system has been tolerized by the tumor antigen (3–6); however, the exact mechanisms of suppression of immunity against TAAs are not known. Since stimulation of dormant antitumor-specific immunity with nominal tumor antigens has had only limited success, an alternative approach to immunize experimental animals or cancer patients with “internal image” (Ab2β or “network” antigens) (7), that is, anti-idiotypic (anti-Id or Ab2) antibodies, has been applied. This method may be effective in breaking tumor antigen-induced tolerance by presenting the critical TAA epitope in a different molecular environment to the tolerized host (8) and may thus break tolerance in tumor-specific immunity. Furthermore, the anti-Id antibodies, the so-called network antigens (7), are the most promising because they are not dependent on genetic idiotypic availability. Consequently, network antigens for a given tumor species would be effective in outbred populations.

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Authors
  1. Heinz Köhler
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  2. Sybille Müller
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Editors and Affiliations

  1. 28, Rue du Dr. Roux, F-75724, Paris Cedex 15, France

    P.-A. Cazenave

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© 1991 Springer-Verlag New York Inc.

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Köhler, H., Müller, S. (1991). Anti-Idiotypic Tumor Vaccines. In: Cazenave, PA. (eds) Anti-Idiotypic Vaccines. Progress in Vaccinology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2992-6_6

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  • DOI: https://doi.org/10.1007/978-1-4612-2992-6_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7750-7

  • Online ISBN: 978-1-4612-2992-6

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