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Stimulation of Lymphocytic Clones by Anti-Idiotypic Antibodies: Basis for Development of Idiotypic Vaccines

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Anti-Idiotypic Vaccines

Part of the book series: Progress in Vaccinology ((VACCINOLOGY,volume 3))

Abstract

Jerne’s network theory of the immune system is strongly supported by numerous findings that there are lymphocytic clones bearing receptors that recognize antigenic markers expressed on the receptors of other clones (1).

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References

  1. Jerne NK: Towards a network theory of the immune response. Ann Immunol (Paris) 1974; 125C:373–389.

    CAS  Google Scholar 

  2. Bona C: Regulatory Idiotopes. New York, Wiley 1987.

    Google Scholar 

  3. Jerne NK, Roland J, Cazenave PA: Recurrent idiotopes and internal images. EMBO J 1982; 1:243–247.

    PubMed  CAS  Google Scholar 

  4. Bona C, Finley S, Waters S, Kunkel HG: Anti-immunoglobulin antibodies III. Properties of sequential anti-idiotypic antibodies to heterologous anti-globulins. Detection of reactivity of antiidiotype antibodies with epitopes of Fc fragments (homobodies), and with epitopes and idiotopes (epibodies). J Exp Med 1982; 156:986–999.

    Article  PubMed  CAS  Google Scholar 

  5. Dwyer DS: Idiotype connectivity of antibody responses specific for self- and nonself antigens. In: Bona CA, ed: Biological Applications of Anti-Idiotypes, II. Boca Raton, Fla: CRC Press; 1988; p 55.

    Google Scholar 

  6. Eichmann K, Rajewsky K: Induction of T and B cell immunity by antiidiotypic antibody. Eur J Immol 1975; 5:661–666.

    Article  CAS  Google Scholar 

  7. Cazenave P-A: Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits. Proc Natl Acad Sci USA 1977; 74:5122–5125.

    Article  PubMed  CAS  Google Scholar 

  8. Urbain J, Wikler M, Franssen JD, Collignon C: Idiotypic regulation of the immune system by the induction of antibodies against antiidiotypic antibodies. Proc Natl Acad Sci USA 1977; 74:5126–5130.

    Article  PubMed  CAS  Google Scholar 

  9. Bona C, Hooghe R, Cazenave P-A, LeGuern C, Paul WE: Cellular basis of regulation of expression of idiotypes II. Immunity to anti-MOPC460 idiotype antibodies increases the level of anti-trinitrophenyl antibodies bearing 460 idiotypes. J Exp Med 1979; 149:815–823.

    Article  PubMed  CAS  Google Scholar 

  10. Hiernaux J, Bona C, Baker P: Neonatal treatment with low doses of antiidiotypic antibody leads to the expression of a silent clone. J Exp Med 1981; 153:1004–1008.

    Article  PubMed  CAS  Google Scholar 

  11. Sacks DL, Esser K, Sher A: Immunization of mice against African trypanosomiasis using antiidiotypic antibodies. J Exp Med 1982; 155:1108–1119.

    Article  PubMed  CAS  Google Scholar 

  12. Bruck C, Co SM, Slaoui M, et al: Nucleic acid sequence of an internal image-bearing monoclonal anti-idiotype and its comparison to the sequence of the external antigen. Proc Natl Acad Sci USA 1986; 83:6578–6582.

    Article  PubMed  CAS  Google Scholar 

  13. Fougereau M, Cambillau C, Corbet S, et al: Molecular basis of anti-idiotype antibodies carrying internal image of antigens. In: Bona CA, ed: Biological Applications of Anti-Idiotypes, I. Boca Raton, Fla: CRC Press 1988: p 23.

    Google Scholar 

  14. Revillard J-P, Brochier J, Vincent C: Modulation of human lymphocyte responses by antibodies directed against lymphocyte surface antigens. In: Bona C, Cazenave P-A, eds: Lymphocytic Regulation by Antibodies. New York; Wiley 1981; p 55.

    Google Scholar 

  15. Infante AJ, Infante PD, Gillis S, Fathman CG: Definition of T-cell idiotopes using antiidiotypic antisera produced by immunization with T-cell clones. J Exp Med 1982; 155:1100–1107.

    Article  PubMed  CAS  Google Scholar 

  16. Bigler RD, Fisher DE, Wang CY, Kau EAR, Kunkel HG: Idiotype-like molecules on cells of a human T cell leukemia. J Exp Med 1983; 158:1000–1005.

    Article  PubMed  CAS  Google Scholar 

  17. Paul WE, Ohara J: B-cell stimulatory/Factor-1/interleukin 4. Ann Rev Immunol 1987; 5:429–459.

    Article  CAS  Google Scholar 

  18. Kaye J, Janeway CA: Fab fragment of a directly activating monoclonal antibody that precipitates a disulfide-linked heterodimer from a helper T cell clone blocks activation by either allogeneic la or antigen and self-Ia. J Exp Med 1984; 159:1397— 1412.

    Article  PubMed  CAS  Google Scholar 

  19. Moran T. Mayer R, and Bona C: Enhancement of anti-influenza response by antiidiotype antibodies. In: Kohler H, LoVerde PT, eds: Vaccines: New Concepts and Developments. New York, Wiley; 1987: p 342.

    Google Scholar 

  20. Mayer R, Ioannides C. Moran T, Johansson B, Bona C: Effect of syngeneic antiidiotype antibody on influenza virus neuraminidase antibody response. Viral Immunol 1987; 1:121–134.

    Article  PubMed  CAS  Google Scholar 

  21. Staudt LM, Gerhard W: Generation of antibody diversity in the immune response; of BALB/c mice to influenza virus hemagglutinin. J Exp Med 1983: 157:687–704.

    Article  PubMed  CAS  Google Scholar 

  22. Heyman B. Andrighetto G, Wigzell H: Antigen-dependent IgM-mediated enhancement of the sheep erythrocyte response in mice: Evidence for induction of B cells with specificities other than that of the injected antibodies. J Exp Med 1982; 155:994–1009.

    Article  PubMed  CAS  Google Scholar 

  23. Francotte M, Urbain J: Induction of anti-tobacco mosaic virus antibodies in mice by rabbit antiidiotypic antibodies. J Exp Med 1984: 160:1485–1494.

    Article  PubMed  CAS  Google Scholar 

  24. Schick MR, Dreesman GR, Kennedy RC: Induction of an anti-hepatitis B surface antigen response in mice by noninternal image (Ab2a) anti-idiotypic antibodies. J Immunol 1987; 138:3419–3425.

    PubMed  CAS  Google Scholar 

  25. Ertl HC, Finberg RW: Sendai virus specific T cell clones: induction of cytolytic T cells by an antiidiotypic antibody directed against a helper T cell clone. Proc Natl Acad Sci USA 1984; 81:2850–2854.

    Article  PubMed  CAS  Google Scholar 

  26. Kaufmann SHE, Eichmann K, Muller L Wrazel LJ: Vaccination against the intracellular bacterium Listeria monocytogenes with a clonotypic antiserum. J Immunol 1985; 134:4123–4127.

    PubMed  CAS  Google Scholar 

  27. Sege K, Paterson PA: Use of antiidiotypic antibodies as cell-surface receptor probes. Proc Natl Acad Sci USA 1978; 75:2443–2447.

    Article  PubMed  CAS  Google Scholar 

  28. Rubenstein LJ, Goldberg B, Hiernaux J. Stein KE, Bona CA: Idiotype-antiidiotype regulation V. The requirement for immunization with antigen and monoclonal antiidiotypic antibodies for the activation of B2 6 and B2 1 polyfructosan reactive clones in BALB/c mice treated at birth with minute amounts of anti-A48 idiotype antibodies. J Exp Med 1983; 158:1129–1144.

    Article  Google Scholar 

  29. Gaulton GN, Sharpe AH, Chang DW, Fields BN, Greene Ml: Syngeneic monoclonal internal image anti-idiotypes as prophylactic vaccines. J Immunol 1986; 137:2930–2936.

    PubMed  CAS  Google Scholar 

  30. Kennedy RC, Ionescu-Matin I, Sanchez Y, Dreesman GR: Detection of interspecies idiotypic cross-reactions associated with antibodies to hepatitis B surface antigen. Eur J Immunol 1983; 13:232–235.

    Article  PubMed  CAS  Google Scholar 

  31. Kennedy RC, Eichberg JW, Lanford RE, Dreesman GR: Anti-idiotype antibody vaccine for type B viral hepatitis in Chimpanzees. Science 1986: 232:220–223.

    Article  PubMed  CAS  Google Scholar 

  32. Thanavala YM, Bond A, Tedder R, Hay FC, Roitt IM: Monoclonal internal image anti-idiotypic antibodies of hepatitis B surface antigen. Immunology 1985; 55:197–204.

    PubMed  CAS  Google Scholar 

  33. Colucci G, Waksal SD: Interactions between hepatitis B virus and polymeric human albumin I. Production of monoclonal anti-idiotypes (anti—anti-polymeric human albumin) which recognize hepatitis B virus surface antigen. Eur J Immunol 1987; 17:365–370.

    Article  PubMed  CAS  Google Scholar 

  34. Colucci G, Beazer Y, Waksal SD: Interactions between hepatitis B virus and poly meric human serum albumin II. Development of syngeneic monoclonal anti anti-idiotypes which mimic hepatitis B surface antigen in the induction of immune responsiveness. Eur J Immunol 1987; 17:371–374.

    Article  PubMed  CAS  Google Scholar 

  35. Uytdehaag FGCM, Osterhaus ADME: Induction of neutralizing antibody in mice against poliovirus type II with monoclonal antiidiotypic antibody. J Immunol 1985; 134:1225–1229.

    PubMed  CAS  Google Scholar 

  36. McNamara MK, Ward RE, Kohler H: Monoclonal idiotype vaccine against Streptococcus pneumoniae infection. Science 1985: 226:1325–1326.

    Article  Google Scholar 

  37. Grzych JM, Capron M, Lambert PH, Dissons C, Torres S, Capron A: An antiidiotypic vaccine against experimental schistosomiasis. Nature 1985; 316:74–76.

    Article  PubMed  CAS  Google Scholar 

  38. Weiss S, Bogen B: B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells. Proc Natl Acad Sci USA 1989; 86:282–286.

    Article  PubMed  CAS  Google Scholar 

  39. Waters SJ, Bona CA: Characterization of a T-cell clone recognizing idiotopes as tumor-associated antigens. Cell Immunol 1988; 111:87–93.

    Article  PubMed  CAS  Google Scholar 

  40. Rees ADM, Scoging A, Dobson N, Praputpittaya K, Young D, Ivanyi J, Lamb J: T cell activation by anti-idiotypic antibody: mechanism of interaction with antigen-reactive T cells. Eur J Immunol 1987; 17:197–201.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Richard Bowen
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  2. Constantin Bona
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Editor information

Editors and Affiliations

  1. 28, Rue du Dr. Roux, F-75724, Paris Cedex 15, France

    P.-A. Cazenave

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© 1991 Springer-Verlag New York Inc.

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Bowen, R., Bona, C. (1991). Stimulation of Lymphocytic Clones by Anti-Idiotypic Antibodies: Basis for Development of Idiotypic Vaccines. In: Cazenave, PA. (eds) Anti-Idiotypic Vaccines. Progress in Vaccinology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2992-6_2

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  • DOI: https://doi.org/10.1007/978-1-4612-2992-6_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7750-7

  • Online ISBN: 978-1-4612-2992-6

  • eBook Packages: Springer Book Archive

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