Van Gogh’s attending physicians in the south of France were terse in their hospital entries about his illness.1 Felix Rey, a young intern, still in training at Arles and yet to receive his medical degree, took care of Vincent after his initial crises. Dr. Peyron, onetime military ophthalmologist and now in a second career, gave asylum at St. Rémy. They have received mixed evaluations.


High Carbohydrate Diet Intermittent Acute Porphyria Acute Intermittent Porphyria Porphobilinogen Deaminase Acute Porphyria 
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References and notes

  1. 1.
    Tralbaut ME. 1981. Vincent van Gogh. New York: The Alpine Fine Arts Collection, Ltd.Google Scholar
  2. 2.
    For this point of view see Gastaut H. 1956. La maladie de Vincent van Gogh envisagée à la lumière des conceptions nouvelles sur l’épilepsie psychomotrice. Annales Medico-Psychologiques vol 1 for 1956: 196–238; wherein Dr. Aussoliel, a friend of Dr. Rey, was deemed to be a local expert on masked epilepsy.Google Scholar
  3. 3.
    Voskuil PHA. 1983. The epilepsy of Fyodor Mikhailovitch Dostoevsky (1821–1881). Epilepsia 24: 658–667.CrossRefGoogle Scholar
  4. 4.
    Lubin AJ. 1987. Stranger on the Earth: A Psychological Biography of Vincent van Gogh. New York: Henry Holt & Co.Google Scholar
  5. 5.
    Arnold WN. 1988. Vincent van Gogh and the thujone connection. Journal of the American Medical Association 260: 3042–3044.CrossRefGoogle Scholar
  6. 6.
    Loftus LS Sc Arnold WN. 1991. Vincent van Gogh’s illness: acute intermittent porphyria? British Medical Journal 303: 1589–1591.CrossRefGoogle Scholar
  7. 7.
    The Complete Letters of Vincent van Gogh. 2nd ed., 1978. Boston: New York Graphic Society.Google Scholar
  8. 8.
    Hemphill RE. 1961. The illness of Vincent van Gogh. Proceedings of the Royal Society of Medicine 54: 1083–1088.Google Scholar
  9. 9.
    Tralbaut ME. op. cit. pp l77–l78.Google Scholar
  10. 10.
    Tralbaut ME. op. cit. p 276.Google Scholar
  11. 11.
    van Gogh-Bonger J. 1978. Memoir of Vincent van Gogh, vol I, pp XLV-XLVI, in: The Complete Letters of Vincent van Gogh. 2nd ed. Boston: New York Graphic Society.Google Scholar
  12. 12.
    Stokvis BJ. 1889. Over twee zeldzame kleurstoffen in urine van zieken. Weekblad van het Nederlandsch Tijdschrift voor Geneeskunde 2: 409–417.Google Scholar
  13. 13.
    With TK. 1980. A short history of porphyrins and the porphyrias. Internationalfournal of Biochemistry 11: 189–200.CrossRefGoogle Scholar
  14. 14.
    Waldenstrom J. 1957. The porphyrias as inborn errors of metabolism. American Journal of Medicine 22: 758–773.CrossRefGoogle Scholar
  15. 15.
    Tishler PV, Woodward B, O’Connor J, Holbrook DA, Seidman LJ, Hallett M Sc Knighton DJ. 1985. High prevalence of intermittent acute porphyria in a psychiatric patient population. American Journal of Psychiatry 142: 1430–1436.Google Scholar
  16. 16.
    Bonkovsky HL, Sinclair PR, Emery S Sc Sinclair JF. 1980. Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. Neurology 30: 588–592.Google Scholar
  17. 17.
    Ivers WM. 1951. Acute intermittent porphyria. Journal of Urology 66: 816–818.Google Scholar
  18. 18.
    Grossfeld E. 1951. Acute porphyria with unusual features. British MedicalJaurnalVol I for 1951: 1240–1241.CrossRefGoogle Scholar
  19. 19.
    Sack GH. Jr. 1990. Acute intermittent porphyria. Journal of the American Medical Association 264: 1290–1293.CrossRefGoogle Scholar
  20. 20.
    Kappas A, Sassa S, Galbraith RA & Nordmann Y. 1989. The porphyrias, pp 1305–1365, in: The Metabolic Basis of Inherited Disease. 6th ed. CR Scriver, AL Beaudet, WS Sly & D Valle (eds.) New York: McGraw-Hill.Google Scholar
  21. 21.
    Laiwah AACY, Mactier R, McColl KEL, Moore MR Sc Goldberg A. 1983. Early-onset chronic renal failure as a complication of acute intermittent porphyria. Quarterly Journal of Medicine 52: 92–98.Google Scholar
  22. 22.
    Lai CW, Hung TP Se Lin WSJ. 1977. Blindness of cerebral origin in acute intermittent porphyria. Archives of Neurology 34: 310–312.Google Scholar
  23. 23.
    Ridley A. 1969. The neuropathy of acute intermittent porphyria. The Quarterly Journal of Medicine 38: 307–333.Google Scholar
  24. 24.
    Moore MR. 1980. International review of drugs in acute porphyria. International Journal of Biochemistry 12: 1089–1097.CrossRefGoogle Scholar
  25. 25.
    Welland FH, Hellman ES, Gaddis EM, Collins A, Hunter GWJr. & Tschudy DR 1964. Factors affecting the excretion of porphyrin precursors by patients with acute intermittent porphyria. I. The effect of diet. Metabolism 13: 232–250.CrossRefGoogle Scholar
  26. 26.
    Knudsen KB, Sparberg M & Lecocq F. 1967. Porphyria precipitated by fasting. New England Journal of Medicine 277: 350–351.CrossRefGoogle Scholar
  27. 27.
    Lip GYH, McColl KEL, Goldberg A & Moore MR. 1991. Smoking and recurrent attacks of acute intermittent porphyria. British Medical Journal 302: 507.CrossRefGoogle Scholar
  28. 28.
    Bickers DR, Miller L & Kappas A. 1975. Exacerbation of hereditary hepatic porphyria by surreptitious ingestion of an unusual provocative agent, a mouthwash preparation. New England Journal of Medicine 292: 1115–1116.CrossRefGoogle Scholar
  29. 29.
    Goldberg A & Rimington C. 1962. Diseases of Porphyrin Metabolism, pp 64–109. Springfield: C.C. Thomas.Google Scholar
  30. 30.
    Battersby AR, Fookes CJR, Matcham GWJ & McDonald E. 1980. Biosynthesis of the pigments of life: formation of the macrocycle. Nature 285: 17–21.CrossRefGoogle Scholar
  31. 31.
    LascellesJ. 1960. The synthesis of enzymes concerned in bacteriochlorophyll formation in growing cultures of Rhodopseudomonas spheroides. Journal of General Microbiology 23: 487–498.Google Scholar
  32. 32.
    Scholnick PL, Hammaker LE & Marver HS. 1969. Soluble hepatic 5-aminolevulinic acid synthetase: end-product inhibition of the partially purified enzyme. Proceedings of the National Academy of Sciences (USA) 63: 65–70.CrossRefGoogle Scholar
  33. 33.
    Tschudy DP, Welland FH, Collins A & Hunter GJr. 1964. The effect of carbohydrate feeding on the induction of 5-aminolevulinic acid synthetase. Metabolism 13: 396–406.CrossRefGoogle Scholar
  34. 34.
    Sassa S, Bradlow HL & Kappas A. 1979. Steroid induction of 5-aminolevulinic acid synthase and porphyrins in liver: structure-activity studies on the permissive effects of hormones on the induction process. Journal of Biological Chemistry 254: 10011–10020.Google Scholar
  35. 35.
    Strand LJ, Felsher BF, Redeker AG & Marver HS. 1970. Enzymatic abnormality in heme biosynthesis in acute intermittent porphyria: decreased hepatic conversion of porphobilinogen to porphyrins and increased 5-aminolevulinic acid synthetase activity. Proceedings of the National Academy of Sciences (USA) 67: 1315–1320.CrossRefGoogle Scholar
  36. 36.
    Magnussen CR, Levine JB, DohertyJM, Cheesman JO & Tschudy DP. 1974. A red cell enzyme method for the diagnosis of acute intermittent porphyria. Blood 44: 857–868.Google Scholar
  37. 37.
    Becker DM & Kramer S. 1977. The neurological manifestations of porphyria: a review. Medicine 56: 411–423.CrossRefGoogle Scholar
  38. 38.
    Müller WE & Snyder SH. 1977. 5-Aminolevulinic acid: influences on synaptic GABA receptor binding may explain CNS symptoms of porphyria. Annals of Neurology 2: 340–342.CrossRefGoogle Scholar
  39. 39.
    Meyer UA, Strand LJ, Doss M, Rees AC & Marver HS. 1972. Intermittent acute porphyria: demonstration of a genetic defect in porphobilinogen metabolism. New England Journal of Medicine 286: 1277–1282.CrossRefGoogle Scholar
  40. 40.
    Litman DA & Correia MA. 1985. Elevated brain tryptophan and enhanced 5-hydroxy- tryptamine turnover in acute hepatic heme deficiency: clinical implications. Journal of Pharmacology and Experimental Therapeutics 232: 337–345.Google Scholar
  41. 41.
    Tschudy DP, Valsamis M & Magnussen CR. 1975. Acute intermittent porphyria: clinical and selected research aspects. Annals of Internal Medicine 83: 851–864.Google Scholar
  42. 42.
    Meyer UA & Schmid R. 1978. The porphyrias, pp 1160–1220, in: The Metabolic Basis of Inherited Disease. 4th ed. JB Stanbury, JB Wyngaarden and DS Fredrickson (eds.) New York: McGraw-Hill Book Company.Google Scholar
  43. 43.
    Lieber CS, Teschke R, Hasumura Y & Decarli LM. 1975. Differences in hepatic and metabolic changes after acute and chronic alcohol consumption. Federation Proceedings 34: 2060–2074.Google Scholar
  44. 44.
    Granick S. 1966. The induction in vitro of the synthesis of ô-aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals. Journal of Biological Chemistry 241: 1359–1375.Google Scholar
  45. 45.
    Mustajoki P & Koskelo P. 1976. Hereditary hepatic porphyrias in Finland. Acta Medica Scandinavica 200: 171–178.CrossRefGoogle Scholar
  46. 46.
    Barker LF & Estes WL. 1912. Family hematoporphyrinuria in association with chronic gastroduodenal dilation, peculiar fits and acute polyneuritis: a preliminary report. Journal of the American Medical Association 59: 718–719.Google Scholar
  47. 47.
    Waldenström J. 1937. Studien ueber Porphyrie. Acta Medica Scandinavica 82 (suppl.): 1–254.Google Scholar
  48. 48.
    Gates RR. 1946. Human Genetics. New York: Macmillan.Google Scholar
  49. 49.
    Wang A-L, Arredondo-Vega FX, Giampietro PF, Smith M, Anderson WF & Desnick RJ. 1981. Regional gene assignment for human porphobilinogen deaminase and esterase-A4 to chromosome llq23→11qter. Proceedings of the National Academy of Sciences (USA) 78: 5734–5738.CrossRefGoogle Scholar
  50. 50.
    Mustajoki P & Desnick RJ. 1985. Genetic heterogeneity in acute intermittent porphyria: characterisation and frequency of porphobilinogen deaminase mutations in Finland. British Medical Journal 291: 505–509.CrossRefGoogle Scholar
  51. 51.
    Kappas A, Bradlow HL, Bickers DR & Alvares AP. 1977. Induction of a deficiency of steroid A4–5-a-reductase activity in liver by a porphyrin gene. Journal of Clinical Investigation 59: 159–169.CrossRefGoogle Scholar
  52. 52.
    Becker B, Shin DH, Palmberg PF & Waltman SR. 1976. H LA antigens and corti¬costeroid response. Science 194: 1427–1437.CrossRefGoogle Scholar
  53. 53.
    Herrick AL, McColl KEL, Wallace AM, Moore MR & Goldberg A. 1990. Elevation of hormone-binding globulins in acute intermittent porphyria. Clinica Chimica Acta 187: 141–148.CrossRefGoogle Scholar
  54. 54.
    Grandchamp B, de Verneuil H, Beaumont C, Chretien S, Walter O & Nordmann Y. 1987. Tissue-specific expression of porphobilinogen deaminase. Two isoenzymes from a single gene. European Journal of Biochemistry 162: 105–110.Google Scholar
  55. 55.
    Grandchamp B, Picat C, Kauppinen R, Mignotte V, Peltonen L, Mustajoki P, Roméo PH, Goossens M & Nordmann Y. 1989. Molecular analysis of acute intermittent porphyria in a Finnish family with normal erythrocyte porphobilinogen deaminase. European Journal of Clinical Investigation 19: 415–418.CrossRefGoogle Scholar
  56. 56.
    Grandchamp B, Picat C, Mignotte V, Wilson JHP, Te Velde K, Sandkuyl L, Roméo PH, Goossens M & Nordmann Y 1989. Tissue-specific splicing mutation in acute intermittent porphyria. Proceedings of the National Academy of Sciences (USA) 86: 661–664.CrossRefGoogle Scholar
  57. 57.
    Goldberg A. 1985. Molecular genetics of acute intermittent porphyria. British Medical Journal 291: 499–500.CrossRefGoogle Scholar
  58. 58.
    Tralbaut ME. loc.dt. pp. 16–17.Google Scholar

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© Birkhäuser Boston 1992

Authors and Affiliations

  • Wilfred Niels Arnold

There are no affiliations available

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