Protective Effects of Intrathecal Lidocaine Administration on Ischemic Injury of the Spinal Cord

  • Eriya Okuda
  • Hiroshi Yoshizu
  • Nobuo Hatori
  • Yoshiyuki Haga
  • Yozo Uriuda
  • Masafumi Shimizu
  • Atsuhiro Mitsumaru
  • Susumu Tanaka


The protective effects of intrathecal lidocaine administration on experimental ischemic spinal cord injury following aortic cross-clamping (AXC) were studied. Twelve mongrel dogs were divided into two groups, six animals in an intrathecally saline-administered group (control group) and the other six in an intrathecally lidocaine-administered group (lidocaine group). The dose of lidocaine administration was determined by the change of somatosensory-evoked potential traces generated by brachial nerve stimulation. Following administration of the agents, all dogs underwent cross-clamping of the thoracic aorta and the left subclavian artery for 60 minutes. Mean proximal aortic pressure during AXC remained in a similar range to baseline pressure until 40 minutes after AXC in the lidocaine group, while it increased significantly in the control group. The ratio of mean distal aortic pressure to mean proximal aortic pressure during AXC (D/P), which was calculated for estimation of collateral blood flow changes, gradually increased in the lidocaine group, but did not change in the control group. Four of six dogs had spastic paraplegia in the control group, but none in the lidocaine group (p < 0.05). Histological examination revealed that extensive infarction of the gray matter was noticed in the control group, but changes in the lidocaine group were only slight. From these results, it was concluded that intrathecal lidocaine administration controlled proximal hypertension effectively, increased D/P during AXC, and diminished neurological damages following AXC.


Spinal Cord Injury Thoracic Aorta Aortic Pressure Left Subclavian Artery Cerebrospinal Fluid Pressure 
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Copyright information

© Springer-Verlag New York Inc. 1992

Authors and Affiliations

  • Eriya Okuda
  • Hiroshi Yoshizu
  • Nobuo Hatori
  • Yoshiyuki Haga
  • Yozo Uriuda
  • Masafumi Shimizu
  • Atsuhiro Mitsumaru
  • Susumu Tanaka

There are no affiliations available

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