Abstract
Vibrio cholerae is the etiologic agent of the diarrheal disease cholera. In response to specific environmental conditions, this organism expresses several virulence determinants including the cholera toxin (Ctx), a toxin coregulated pilus (Tcp), and accessory colonization factor (Acf; DiRita and Mekalanos,1989; Taylor et al., 1987; Peterson and Mekalanos, 1988). These gene products are part of a regulon under the control of the products of the toxRS locus of V cholerae (Taylor et al., 1987; Peterson and Mekalanos, 1988). ToxR is a transmembrane protein that binds specifically to the promoter for the operon encoding the cholera toxin (ctxAB) and activates transcription from this promoter in Escherichia coli (Miller and Mekalanos, 1985; Millers et al., 1987).
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© 1992 Springer-Verlag New York, Inc.
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DiRita, V.J., Parsot, C., Jander, G., Mekalanos, J.J. (1992). A Regulatory Cascade Controls Virulence in Vibrio cholerae . In: Hook, M., Switalski, L. (eds) Microbial Adhesion and Invasion. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2924-7_7
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DOI: https://doi.org/10.1007/978-1-4612-2924-7_7
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