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The Integrins: A General Overview

  • Jonathan M. Edelman
  • Clayton A. Buck
Conference paper

Abstract

The integrins are a family of cell surface molecules involved in several important events including cell substratum adhesion, cell-cell adhesion, cell migration, cell differentiation and signal transduction. They include receptors for extracellular matrix molecules such as fibronectin, laminin and collagen (Hynes, 1987; Buck and Horwitz, 1987b; Ruoslahti and Pierschbacher, 1987; Akiyama et al., 1990) as well as receptors that are involved in lymphocyte adhesion to one another and to the vascular endothelium (Springer, 1990; Nakamura et al., 1990; Albelda and Buck, 1990; Elices et al., 1990). Their importance to neural crest cell migration (Bronner-Fraser, 1985; Bronner-Fraser, 1986), gastrulation (Boucaut et al., 1984), and neurogenesis (Reichardt and Tomaselli, 1991) during embryonic development has been well documented. They also appear to function as mediators of signals from the extracellular environment. For example, antibodies that react with integrins can interfere with muscle development (Menko and Boettiger, 1987) as well as stimulate the secretion of proteolytic enzymes (Werb et al., 1989). Integrins also serve as accessory molecules during the stimulation of lymphocytes (Shimizu et al., 1990b; Shimizu et al., 1990a). Finally, they serve as the binding sites for certain pathogenic bacteria and fungi (Leong et al., 1990; Isberg and Leong, 1990; Bullock and Wright, 1987).

Keywords

Bullous Pemphigoid Integrin Expression Integrin Subunit Bordetella Pertussis Extracellular Matrix Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Jonathan M. Edelman
  • Clayton A. Buck

There are no affiliations available

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